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2013 | 16 | 1 |

Tytuł artykułu

Ontogeny of the long form of leptin receptor gene expression in the porcine ovarian follicles

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Leptin is a polypeptide hormone produced predominantly in adipocytes. It has been found to be implicated in the regulation of satiety and energy homeostasis. A role for leptin in reproduction was later suggested by findings that this hormone may be involved in the regulation of the hypothalamic- pituitary-gonadal axis via endocrine, paracrine and/or autocrine pathways. The objective of the study was to investigate the ontogeny of the long isoform of leptin receptor (OB-Rb) gene in porcine ovarian follicles. The expression of OB-Rb gene was detected in porcine primordial, primary, secondary and antral follicles by in situ hybridization. In summary, our data suggest that leptin might have a direct effect on porcine follicles and plays an important role in the follicular development.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

16

Numer

1

Opis fizyczny

p.101-105,fig.,ref.

Twórcy

autor
  • Department of Animal Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719 Olsztyn, Poland
autor
  • Department of Animal Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719 Olsztyn, Poland
autor
  • Department of Animal Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719 Olsztyn, Poland
autor
  • Department of Animal Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719 Olsztyn, Poland

Bibliografia

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  • Antczak M, Van Blerkom J (1997) Oocyte influences on early development: the regulatory proteins leptin and STAT3 are polarized in mouse and human oocytes and differentially distributed within the cells of the preimplantation stage embryo. Mol Hum Reprod 3: 1067-1086.
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  • Bjorbaek C, Uotani S, da Silva B, Flier JS (1997) Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 272: 32686-32695.
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  • Cioffi JA, Van Blerkom J, Antczak M, Shafer A, Wittmer S, Snodgrass HR (1997) The expression of leptin and its receptors in pre-ovulatory human follicles. Mol Hum Reprod 3: 467-472.
  • Gregoraszczuk EL, Ptak A, Wojtowicz AK, Gorska T, Nowak KW (2004) Estrus cycle-dependent action of leptin on basal and GH or IGF-I stimulated steroid secretion by whole porcine follicles. Endocr Regul 38: 15-21.
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  • Karamouti M, Kollia P, Kallitsaris A, Vamvakopoulos N, Kollios G, Messinis IE (2009) Modulating effect of leptin on basal and follicle stimulating hormone stimulated steroidogenesis in cultured human lutein granulosa cells. J Endocrinol Invest 32: 415-419.
  • Karlsson C, Lindell K, Svensson E, Bergh C, Lind P, Billig H, Carlsson LM, Carlsson B (1997) Expression of functional leptin receptors in the human ovary. J Clin Endocrinol Metab 82: 4144-4148.
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Bibliografia

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