Prevalence of Polyoma BK virus ( BKPyV) , Epstein-Barr virus (EBV) and Human Papilloma virus (HPV) in oropharyngeal cancer

• Autorzy: Polz-Gruszka D. , Morshed K. , Jarzynski A. , Polz-Dancewicz M.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to analyze the prevalence of BK virus, Human Papillomavirus and Epstein-Barr virus in oropharyngeal cancer, and to test our hypothesis that BKV/HPV/EBV co-infection plays a role in oropharyngeal squamous cell carcinoma. The correlation between viral infection, OSCC, anatomic location, pre-treatment staging, evidence of metastases to lymph nodes, and grading was also investigated. The examination samples were collected from 62 patients from paraffin tissue blocks. Males (90.3%) with, smoking (83.9%) and alcohol abuse (67.7%) problems prevailed in the studied group. G2 histological type was recognized in 80.6% cases. T4 (77.4%) and N2 (56.5%) traits occurred in the majority of patients. No cases of metastasis were observed (M0 100%). HPV – 24.2%, EBV – 27.4% and BKV 17.7% were detected in the studied samples. We observed co-infection EBV/BKV in 8% of cases, HPV/BKV in 4.8%, and HPV/EBV in 9% cases. Only in two cases co-infection of all three viruses was found.

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2015
• Tom: 64
• Numer: 4
• Opis fizyczny: p.323-328,ref.

Twórcy

autor

Polz-Gruszka D.

• Department of Virology, Medical University, Lublin, Poland

autor

Morshed K.

• Chair and Department of Otolaryngology and Laryngological Oncology, Medical University Lublin, Poland

autor

Jarzynski A.

• Department of Virology, Medical University, Lublin, Poland

autor

Polz-Dancewicz M.

• Department of Virology, Medical University, Lublin, Poland

Bibliografia

• Alibek K., A. Kakpenova and Y. Baiken. 2013. Role of infectious agents in carcinogenesis of brain and head and neck cancers. Infect. Agent. Cancer 8(1): 7.
• Arthur R.R., S. Dagostin and K.V. Shah. 1989. Detection of BK virus and JC virus in urine and brain tissue by the polymerase chain reaction. J. Clin. Microbiol. 27: 1174–1179.
• Acharya S., T. Ekalaksananan, P. Vatanasapt, K. Loyha, P. Phusingha, S. Promthet, B. Kongyingyoes and C. Pientong. 2014. Association of Epstein-Barr virus infection with oral squamous cell carcinoma in a case-control study. J. Oral. Pathol. Med. 43: 507–513.
• Alipov G., T. Nakayama, M. Nakashima, C.Y. Wen, D. Niino, H. Kondo, Y. Pruglo and I. Sekine. 2005. Epstein-Barr virus associated gastric carcinoma in Kazakhstan. World J. Gastroenterol. 11: 27–30.
• Al Mustafa A.E., D. Chen, L. Ghabreau and N. Akil. 2009. Association between human papillomavirus and Epstein-Barr virus infections in human oral carcinogenesis. Med. Hypotheses. 73: 184–189.
• Bennett S., N. Broekema and M. Imperiale. 2012. BK polyomavirus: emerging pathogen. Microbes Infect. 14: 672–683.
• Burger-Calderon R., V. Madden, R. Hallett, A.D. Gingerich, V. Nickeleit and J. Webster-Cyriaque. 2014. Replication of oral BK virus in human salivary glands. J. Virol. 88: 559–573.
• Cardesa A., N. Gale and A. Nadal and N. Zidor. 2010. Squamous cell carcinoma in World Health Organization Classifiation of Tumours. Pathology and Genetics: Head and Neck Tumours, pp. 118–121. In: Barnes L., J.W. Eveson, P. Reichart and D. Sidnousky (eds.). International Agency for Research on Cancer, Lyon.
• Castro Peixoto Patury Galvao T. and I. Busolotti. 2006. Prevalance of Human papillomavirus (HPV) in oral and oropharynx. Rev. Bras. Otorrinolaringol 2: 1–14.
• Chen M.R. 2011. Epstein-Barr virus, the immune system, and associated diseases. Front Microbiol. 2: 5.
• Comar M., D. Bonifacio, F. Zanconati, M. Di Napoli, E. Isidoro, F. Martini, L. Torelli. and M. Tognon. 2011. High prevalence of BK poliyomavirus sequences in Human papillomavirus-16-positive precancerous cervical lesions. J. Med. Virol. 83: 1770–1776.
• Didkowska J., U. Wojciechowska and Z. Zatoński. 2013. Cancer in Poland in 2011. Oncology Centre – Oncology Institute Maria Skłodowska-Curie, Warsaw.
• Fraase K., J. Hart, H. Wu, X. Pang, L. Ma, F. Grant, A. Li, A. Lennon, P.C. Hu and J. Dong. 2011. BK virus bas a potential co-factor for HPV in the development of cervical neoplasia. Ann. Clin. Lab. Sci. 42: 130–134.
• Hachana M., K. Amara, S. Ziadi, R.B. Gacem, S. Korbi and M. Trimeche. 2012. Investigation of human JC and BK polyomaviruses in breast carcinomas. Breast Cancer Res. Treat. 133: 969–977.
• Hillbertz N.S., J.M. Hirsch, J. Jalouli, M. Jalouli and L. Sand. 2012. Viral and molecular aspects of oral cancer. Anticancer Res. 32(10): 4201–4212.
• IARC monographs on the evaluation of carcinogenic risks to humans. 2007. In: Cancer IAfRo, ed Lyon, France. World Health Organization, 222–230, 670.
• IARC monographs on the evaluation of carcinogenic risks to humans a review of human carcinogens. Biological agents. 2012. Lyon, World Health Organization, 255.
• IARC-Proceedings of the IARC working group on the evaluation of carcinogenic risks to tumors. Epstein-barr virus and Kaposi’ sarcoma Herpesvirus/Human herpesvirus 8. 1997. Lyon, France 17–24 June. IARC Monogr Eval Carcinog Risks Hum. 1997; 70: 1–492.
• Jalouli J., S.O. Ibrahim, R. Mehrotra, M.M. Jalouli, D. Sapkota, P.A. Larson and J.M. Hirsch. 2010. Prevalence of viral (HPV, EBV, HSV) infections in oral submucous fibrosis and oral cancer from India. Acta Oto-Laryngologica 130: 1306–1311.
• Jalouli J., S.O. Ibrahim, D. Sapkota, M.M. Jalouli, E.N. Vasstrand, J.M. Hirsch and P.A. Larson. 2011. Presence of human papilloma virus, herpes simplex virus and Epstein-Barr virus DNA in oral biopsies from Sudanese patients with regard to toombak use. J. Oral. Pathology Med. 19: 599–604.
• Jalouli J., M.M. Jalouli, D. Sapkota, S.O. Ibrahim, P.A. Larson and L. Sand. 2012. Human papilloma virus, herpes simplex and Epstein-Barr virus in oral squamous cell carcinoma from eight different countries. Anticancer Res. 32: 571–580.
• Jeffers L.K., V. Madden and J. Webster-Cyriaque. 2009. BK virus has tropism for human salivary gland cells in vitro: Implications for transmission. Virology 394: 183–193.
• Jiang R., O. Ekshyyan, T. Moore-Medlin, X. Rong, S. Nathan, X. Gu, F. Abreo, E.L. Rosenthal, M. Shi, J.T. Guidry and others. 2015. Association between human papilloma virus/Epstein-Barr virus coinfection and oral carcinogenesis. J. Oral. Pathol. Med. 44: 28–36.
• Kis A., K. Feher, T. Gall, I. Tar, R. Boda, E.D. Toth, G. Mehes, L. Gergely and K. Szarka. 2009. Epstein-Barr virus prevalence in oral squamous cell cancer and potentially malignant oral disorders in an eastern Hungarian population. Eur. J. Oral Sci. 117: 537–540.
• Konietzny R., R. Fischer, N. Ternette, C. Wright, B. Turney, A. Chakera, D. Hughes, B.M. Kessler and C.W. Pug. 2012. Detection of BK virus in urine from renal transplant subjects my mass spectrometry. Clin. Proteomics. 9: 4–13.
• Metgud R., M. Astekar, M. Verma and A. Sharma. 2012. Role of viruses in oral squamous cell carcinoma. Oncol. Rev. 6: 164–170.
• Moens U., M. Van Ghule and B. Ehlers. 2014. Are human polyomaviruses co-factors for cancers induced by other oncoviruses? Rev. Med. Virol. 24: 343–360.
• Neirynck V., K. Claes, M. Naesens, L. De Wever, J. Pirenne, D. Kuypers, Y. Vanrenterghem, H.V. Poppel, A. Kabanda and E. Lerut. 2012. Renal cell carcinoma in the allograft: what is the role of Polyomavirus? Case Rep. Nephrol. Urol. 2: 125–134.
• Peh S.C., L.H. Kim, K.S. Mun, E.L. Tam, C.K. Sam and S. Poppema. 2003. Epstein-Barr virus (EBV) subtypes and variants in malignant tissue from Malaysian patients. J. Clin. Exp. Hematopathol. 43: 61–69.
• Perera R.A., L.P. Samaranayake and C.S.P. Tsang. 2010. Shedding dynamics of Epstein-Barr virus: A type 1 carcinogen. Arch. Oral. Biol. 55: 639–647.
• Polz-Gruszka D., A. Stec, J. Dworzański and M. Polz-Dacewicz. 2015. EBV, HSV, CMV and HPV in laryngeal and oropharyngeal carcinoma in Polish patients. Anticancer Res. 35(3): 1657–1661.
• Polz D., K. Morshed, A. Stec, Ł. Podsiadło and M. Polz-Dacewicz. 2015. Do polyomavirus hominis strains BK and JC play a role in oral squamous cell carcinoma? Ann. Agric. Environ. Med. 22: 106–109 (in press).
• Raeesi N., A. Gheissari, M. Akrami and S. Moghim. 2012. Urinary BK virus excretion in children newly diagnosed with acute lymphoblastic leukemia. Int. J. Prev. Med. (6): 402–407.
• Ritchie J.M., E.M. Smith, K.F. Summersgill, H.T. Hoffman, D. Wang, J.P. Klussmann, L.P. Turek and T.H. Haugen. 2003. Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. Int. J. Cancer 104: 336–344.
• Sand L. and J. Jalouli. 2014. Viruses and oral cancer. Is there a link. Microbes and infection 16: 1–8.
• Sand L., M. Wallström and J.M. Hirsch. 2014. Smokeless tobacco, viruses and oral cancer. Oral. Health. Dent. Manag.13: 372–378.
• Sathish N., X. Wang and Y. Yuan. 2014. Human Papillomavirus (HPV) associated oral cancers and treatment strategies. J. Dent. Res. 93: 29S–36S.
• Scully C. 2011. Oral cancer aetiopathogenesis: past, present and future aspects. Med. Oral. Pathol. Cir. Bucal. 16: e306–311.
• Schowalter R., W. Reinhold and C. Buck. 2012. Entry tropism of BK and Merkel cell polyomaviruses in cell culture. PLoS One 7: e42181.
• Senyuta N., L. Yakovleva, E. Goncharova, L. Scherback, S. Diduk, K. Smirova, D. Maksimovich and V. Gurtsevitch. 2013. Epstein-Barr Virus latent membrane protein 1 polymorphism in nasopharyngeal carcinoma and other oral cavity tumors in Russia. J. Med. Virol. 86: 290–300.
• Siennicka J., A. Trzcińska, A. Częścik, M. Dunal-Sczepaniak and B. Łagosz. 2013. The influence of toll-like receptor stimulation on expression of EBV lytic genes. Pol. J. Microbiol. 62: 237–242.
• Slots J. 2005. Herpesviruses in periodontal diseases. Periodontol 2000. 38: 33–62.
• Slots J., I. Saygun, M. Sabeti and A. Kubar. 2006. Epstein-Barr virus in oral diseases. J. Periodontal Res. 41: 235–244.
• Sobin L.H., M. Gospodarowicz and C. Wittekind. 2009. TNM Classification of Malignant Tumours 7th Edition, pp. 22–45. Washington DC, Wiley-Blackwell.
• Syrjänen K.J., S.M. Syrjänen, M.A. Lamberg and S. Pyrhönen. 1983. Human papillomavirus (HPV) involvement in squamous cell lesions of the oral cavity. Proc. Finn. Dent. Soc. 79: 1–8.
• Syrjänen K. and S. Syrjänen. 2013. Detection of human papillomavirus in sinonasal carcinoma: systematic review and meta-analysis. Human Pathol. 44: 983–991.
• Szkaradkiewicz A., A. Kruk-Zagajewska, M. Wal, A. Jopek, M. Wierzbicka and A. Kuch. 2002. Epstein-Barr virus and human papillomavirus infections and oropharyngeal squamous cell carcinomas. Clin. Exp. Med. 23: 137–141.
• Szkaradkiewicz A., M. Wal, A. Kuch and P. Pieta. 2004. Human papillomavirus (HPV) and Epstein Barr virus (EBV) cervical infections in normal and abnormal cytology. Pol. J. Microbiol. 53: 95–99.
• Szostek S., B. Zawilińska, C. Kopeć and M. Kosz-Vnenchak. 2009. Herpesvirus as possible cofactors in HPV-16 related oncogenesis. Acta Biochim. Pol. 56: 337–342.
• Tiwawech D., P. Srivatankul, A. Karalak and T. Ishida. 2008 Association between EBNA2 and LMP1 subtypes of Epstein-Barr virus and nasopharyngeal carcinoma in Thais. J. Clin. Virol. 43: 1–6.
• Tognon M., A. Corallini, F. Martini, M. Negrini and G. BarbantiBrodano. 2003. Oncogenic transformation by BK virus and association with human tumors. Oncogene 22: 5192–5200.
• zur Hausen H. 1976.Biochemical approaches to detection of Epstein-Barr virus in human tumors. Cancer Res. 36: 678–680.

Identyfikatory

DOI

10.5604/17331331.1185229