Review on pharmacological effects of Plectranthus forskohlii (Willd) briq

• Autorzy: Lakshmanan G.M.A. , Manikandan S.
• Języki publikacji: EN

Abstrakty

EN

Plectranthus forskohlii (Willd). Briq. (Syn: Coleus forskohlii) is an important indigenous medicinal plant in India. It has been used in traditional Ayurveda medicine for curing various disorders and this is the only source of the diterpenoid forskolin. Forskolin is used for the treatment of eczema, asthma, psoriasis, cardiovascular disorders and hypertension, where decreased intracellular cAMP level is believed to be a major factor in the development of the disease process. A comprehensive account of the morphology, medicinal uses, phytochemistry, pharmacological activities, analytical methods and biotechnological approaches for forskolin production reported are included in view of the many recent findings of importance on this plant.

Słowa kluczowe

EN

India; medicinal plant; Plectranthus; Coleus forskohlii; phytochemistry; pharmacology; forskolin

• Wydawca: -
• Czasopismo: International Letters of Natural Sciences
• Rocznik: 2015
• Tom: 01
• Opis fizyczny: p.1-9,ref.

Twórcy

autor

Lakshmanan G.M.A.

• Department of Botany, Annamalai University, Annamalai Nagar 608 002, India

autor

Manikandan S.

• Department of Botany, Annamalai University, Annamalai Nagar 608 002, India

Bibliografia

• [1] Adnot S, Desmier M, Ferry N, Hanoune J and Sevenet T. Forskolin – a powerful inhibitor of human platelet aggregation. Biochem. Pharmacol. 1982; 31:4071-4074.
• [2] Agarwal KC and Parks RE, Forskolin: a potential antimetastatic agent. Int. J. Cancer. 1983; 32:801-804.
• [3] Ammon HP and Kemper FH, Ayurveda: 3000 years of Indian traditional medicine. Med. Welt. 1982; 33:148-153.
• [4] Ammon HP and Muller AB, Forskolin: from an Ayurvedic remedy to a modern agent. Planta. Med.1985; 6:473-477.
• [5] Bailey LH. Standard Cyclopedia of Horticulture. 1942; Macmillan, New York.
• [6] Bauer K, Dietersdorder F, Sertl K, Kaik B and Kaik G, Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. Clin. Pharmacol. Ther.; 1993; 53:76-83.
• [7] Brubaker RF, Carlson KH, Kullerstrand LJ and Mclaren JW. Topical forskolin (colforsin) and aqueous flow in humans. Arch Ophthalmol.; 1987; 105:637-641.
• [8] Bruka JF. Forskoli: Its chemical biological and medical potential. In: Proc. Int. Symp. Forskolin, Hoechst India Ltd., Bombay; pp. 1986; 117-136.
• [9] Chowdhary AR, Sharma ML. GC-MS investigations on the essential oil from Coleus forskohlii Briq. Indian Perfumer 1998; 42:15-16.
• [10] De Souza NJ and Shah V. Forskolin – an adenylatecyclase activating drug from an Indian herb. Econ. Med. Plant Res.; 1988; 2:1-16.
• [11] De Souza NJ, Dohadwalla AN, Reden J. Forskolin: a labdane diterpenoid with anti-hypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties. Med. Res. Rev. 1983; 3:201-219.
• [12] Demetzos C, Kolocouris A, Anastasaki T. A simple andrapid method for the differentiation of C-13 manoyloxide epimersin biologically important samples using GC-MS analysis supported with NMR spectroscopy and computational chemistry results. Bio Org Med Chem Lett .2002; 12:3605-3609.
• [13] Dubey MP, Srimal RC, Nityanand S, Dhawan BN. Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohlii. J. Ethnopharmacol. 1981; 3:1-13.
• [14] Han LK, Morimoto C, Yu RH, Okuda H. Effects of Coleus forskohlii on fat storage in ovariectomized rats. Yakugaku Zasshi. 2005; 125:449-453.
• [15] Henderson S, Magu B, Rasmussen C, Lancaster S, Kerksick C, Smith P, Melton C, Cowan P, Greenwood M, Earnest C, Almada A, Milnor P, Magrans T, Bowden R, Ounpraseuth S, Thomas A, Kreider RB. Effects of Coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. J. Int. Soc. Sports Nutr. 2005; 9:54-62.
• [16] Hosono M, Takahira T, Fujita A, Fujihara R, Ishizuka O, Ohio I, Tatee T, Nakamura K. Cardiovascular effects of NICH 477, a novel potent water soluble forskolin derivative. Eur. J. Pharmacol. 1990; 183:2110.
• [17] Inamdar PK, Dornauer H, deSouza NJ. GLC method for assay of forskolin, a novel positive inotropic and blood pressure-lowering agent. J. Pharm. Sci. 1980; 69:1449-1451.
• [18] Inamdar PK, Kanitkar PV, Reden J, deSouza NJ. Quantitative determination of forskolin by TLC and HPLC. Planta Med. 1984; 50:30-34.
• [19] Lee PY, Podos SM, Serle JB, Camras CB and Severin CH. Intraocular pressure effects of multiple doses of drugs applied to glaucomatous monkey eyes. Arch Ophthalmol.; 1987; 105:249-252.
• [20] Marone G, Columbo M, Triggiani M, Cirillo R, Genovese A and Formisano S. Inhibition of IgE-mediated release of histamine and peptide leukotriene from human basophils and mast cells by forskolin. Biochem. Pharmacol.; 1987; 36:13-20.
• [21] Rajangam J. Studies on the effect of planting methods and growth regulators on growth, tuber development, yield and quality, and standardization of post-harvest technology of Coleus (Coleus forskohlii Briq.)". Ph. D Thesis, Tamil Nadu Agricultural University, Coimbatore. 2005.
• [22] Rupp RH, De Souza NJ and Dohadwalla AN. Forskolin: Its chemical, biological and medical potential. In: Proc. Int. Symp. Forskolin., Hoechst India Limited, Bombay.; 1986; pp. 19-30.
• [23] Saksena AK, Green MJ, Shue HJ. Identity of coleonol with forskolin: Structure revision of a base-catalyzed rearrangement product. Tetra hedron Lett. 1985; 26:551-554.
• [24] Saleem AM, Dhasan PB, Rafiullah MR. Simple and rapid method for the isolation of forskolin from Coleus forskohlii by charcoal column chromatography. J Chromatograph. 2006; 1101:313-314.
• [25] Schaneberg BT, Khan IA. Quantitative analysis of forskolin in Coleus forskohlii (Lamiaceae) by reversed-phase liquid chromatography. J AOAC Int. 2003; 86: 467-470.
• [26] Shah V, Bhat SV, Bajwa BS, Dornaeur H, De Souza NJ. The occurrence of forskolin in Labiatae. Planta Medica. 1980; 39:183-185.
• [27] Shan Y, Xu L, Lu Y, Wang X, Zheng Q, Kong L, Niwa M. Diterpenes from Coleus forskohlii. Chem Pharm Bull. 2008; 56:52-56.
• [28] ShanY, Wang X, Zhou X, Kong L, Niwa M. Two minor diterpene glycosides and aneudesman sesquiterpene from Coleus forskohlii. Chem. Pharm. Bull. 2007; 55:376-81.
• [29] Shen YH, Xu YL. Two new diterpenoids from Coleus forskohlii. J. Asian Nat. Prod. Res.2005; 7:811-815
• [30] Siegl AM, Daly JW and Smith JB. Inhibition of aggregation and stimulation of cyclic AMP generation in intact human platelets by the diterpeneforskolin. Mol Pharmacol.; 1982; 21:680-687.
• [31] Valdes LJ, Mislankar SG, Paul AG. Coleus barbatus (C. forskohlii) (Lamiaceae) and the potential new drug forskolin (Coleonol). Econ. Bot. 1987; 44:474-483.
• [32] Wu HZ, Yang QR, Yang YF, Liu YW. Studies on HPLC-ELSD fingerprint of the Coleus forskohlii introduced in Tongcheng. Zhong Yao Cai. 2007; 30:1370-1374.
• [33] Wysham DG, Brotherton AF and Heistad DD. Effects of forskolin on cerebral blood flow: implications for a role of adenylatecyclase. Stroke; 1986; 17:1299-1303.
• [34] Xu LL, Lu J, Li WJ, Kong LY. Studies on the chemical constituents in root of Coleus forskohlii. Zhongguo ZhongYao ZaZhi. 2005; 30:1753-1755.
• [35] Yanagihara H, Sakata R, Shoyama Y, Murakami H. Rapid analysis of small samples containing forskolin using monoclonal antibodies. Planta Med. 1996; 62:169-172.