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2011 | 55 | 2 |

Tytuł artykułu

Effect of human chorionic gonadotropin on endotoxaemic stallions

Autorzy

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The effects of Escherichia coli endotoxin and human chorionic gonadotropin (hCG) on certain clinical and pathological variables and serum testosterone concentration were studied in the breeding stallions. The study was conducted on 10 stallions of Polish Primitive Horses divided into three groups: group I (n=3) - exposed to 0.3 µg/kg b.w of LPS Escherichia coli; group II (n=3) -treated with physiological saline solution and human chorionic gonadotropin in the single dose of 6,000 IU; and group III (n=4) - given endotoxin and hCG. Rectal temperature, scrotal skin temperature, heart rate, and white blood cell count were determined. Serum blood samples were measured for testosterone concentrations. Comparing the group of stallions with the saline solution+hCG with endotoxin-treated stallions, there were significant clinical and haematological alterations (fever, with rise of rectal and scrotal temperature, tachycardia, and leukopoenia). Endotoxaemia resulted also in changes of serum testosterone concentration (with early decrease and later increase). The hCG has not prevented the decrease in level of testosterone.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

55

Numer

2

Opis fizyczny

p.223-229,fig.,ref.

Twórcy

autor
  • Department of Animal Reproduction and Animal Health Protection, University of Technology and Life Sciences, 85-084 Bydgoszcz, Poland

Bibliografia

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  • 2. Bollwein H., Schulze J.J., Miyamoto A., Sieme H.: Testicular blood flow and plasma concentrations of testosterone and total estrogen in the stallion after the administration of human chorionic gonadotropin. J Reprod Dev 2008, 54, 335-339.
  • 3. Bosmann H.B., Hales K.H., Li X., Liu Z., Stocco D.M., Hales D.B.: Acute in vivo inhibition of testosterone by endotoxin parallels loss of steroidogenic acute regulatory (StAR) protein in Leydig cells. Endocrinology 1996, 137, 4522-4525.
  • 4. Calkins C.M., Bensard D.D., Shames B.D., Pulido E.J., Abraham E., Fernandez N., Meng X., Dinarello C.A., McInntyre R.C.Jr: IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia. J Endotoxin Res 2002, 8, 59-67.
  • 5. Cargile J.L., MacKay R.J., Dankert J.R., Skelley L.: Effect of treatment with a monoclonal antibody against equine tumor necrosis factor (TNF) on clinical, hematologic, and circulating TNF responses of Miniature Horses given endotoxin. Am J Vet Res 1995, 56, 1451-1459.
  • 6. Conti B., Tabarean I., Andrei C., Bartfai T.: Cytokines and fever. Front Biosci 2004, 9, 1433-1449.
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  • 12. Dinarello C.A.: Review: infection, fever, and exogenous and endogenous pyrogens: some concepts have changed. J Endotoxin Res 2004, 10, 201-222.
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  • 15. Jaeschke H., Farhood A., Fischer M.A., Smith C.W.: Sequestration of neutrophils in the hepatic vasculature during endotoxemia is independent of ß2 integrins and intercellular adhesion molecule-1. Shock 1996, 6, 351- 356.
  • 16. Jonsson C.K., Brian P., Setchell B.P., Martinelle N., Svechnikov K., Söder O.: Endotoxin-induced interleukin 1 expression in testicular macrophages is accompanied by downregulation of the constitutive expression in Sertoli cells. Cytokine 2001, 14, 283-288.
  • 17. Krumrych W., Wiśniewski E., Dąbrowska J., Danek J.: Activation of blood neutrophils in horses with the use of different doses of endotoxin. Bull Vet Inst Pulawy 1997, 41, 41-47.
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  • 20. O'Bryan M.K., Schlatt S., Phillips D.J., Krester D.M., Hedger M.P.: Bacterial lipopolysaccharide-induced inflammation compromises testicular function at multiple levels in vivo. Endocrinology 2000, 141, 238- 246.
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  • 23. Reddy M.M., Mahipal S.V.K., Subhashini J., Reddy J.M., Roy K.R., Reddy G.V., Pingili R.K., Reddy P.R.K., Reddanna P.: Bacterial lipopolysaccharide-induced oxidative stress in the impairment of steroidogenesis and spermatogenesis in rats. Reprod Toxicol 2006, 22, 493-500.
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  • 28. Tsunoda N., Weng Q., Nagata S., Taniyama H. Watanabe G., Taya K: Effect of a single injection of human chorionic gonadotropin (hCG) on testicular hormones and gonadotropins in the thoroughbred stallion. J Equine Sci 2007, 18, 107-115.
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  • 32. Ward D.S., Fessler J.F., Bottoms G.D., Turek J.: Equine endotoxemia: cardiovascular, eicosanoid, hematologic, blood chemical, and plasma enzyme alterations. Am J Vet Res 1987, 48, 1150-1156.
  • 33. Werners A.H., Bull S., Fink-Gremmels J.: Endotoxaemia: review with implications for the horses. Equine Vet J 2005, 37, 371-383.
  • 34. Wiśniewski E., Krumrych W., Danek J.: Latency period and developmental phases of fever in horses. Bull Vet Inst Pulawy 1992, 36, 31-38.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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