Face processing in a case of high functioning autism with developmental prosopagnosia

• Autorzy: Cygan H.B. , Okuniewska H. , Jednorog K. , Marchewka A. , Wypych M. , Nowicka A.
• Języki publikacji: EN

Abstrakty

EN

The ability to “read” the information about facial identity, expressed emotions, and intentions is crucial for non-verbal social interaction. Neuroimaging and clinical studies consequently link face perception with fusiform gyrus (FG) and occipital face area (OFA) activity. Here we investigated face processing in an adult, patient PK, diagnosed with both high functioning autism spectrum disorder (ASD) and developmental prosopagnosia (DP). Both disorders have a significant impact on face perception and recognition, thus creating a unique neurodevelopmental condition. We used eye-tracking and functional magnetic resonance imaging (fMRI) method. Eye-tracking and fMRI results of PK were compared to results of control subjects. Patient PK showed atypical gaze-fixation strategy during face perception and typical patterns of brain activations in the FG and OFA. However, a significant difference between PK and control subjects was found in the left anterior superior temporal sulcus/middle temporal gyrus (aSTS/MTG). In PK the left aSTS/MTG was hypo-activated in comparison to the control subjects. Additionally, functional connectivity analysis revealed decreased inter-hemispheric connectivity between right and left aSTS/MTG in ‘ASD and DP’ patient during face recognition performance as compared to the control subjects. The lack of activity in the left aSTS/MTG observed in the case of the clinical subject, combined with the behavioral, eye-tracking, and neuropsychological results, suggests that impairment of the cognitive mechanism of face recognition involves higher level of processing. It seems to be related to insufficient access to semantic knowledge about the person when prompted by face stimuli.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2018
• Tom: 78
• Numer: 2
• Opis fizyczny: p.114-131,fig.,ref.

Twórcy

autor

Cygan H.B.

• Laboratory of Social Psychology, Department of Ergonomics, Central Institute for Labour Protection, National Research Institute, Warsaw, Poland
• Laboratory of Psychophysiology, Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Science, Warsaw, Poland

autor

Okuniewska H.

• Faculty of Psychology, University of Warsaw, Warsaw, Poland

autor

Jednorog K.

• Laboratory of Psychophysiology, Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Science, Warsaw, Poland

autor

Marchewka A.

• Laboratory of Brain Imaging, Neurobiology Center, Nencki Institute of Experimental Biology, Polish Academy of Science, Warsaw, Poland

autor

Wypych M.

• Laboratory of Brain Imaging, Neurobiology Center, Nencki Institute of Experimental Biology, Polish Academy of Science, Warsaw, Poland

autor

Nowicka A.

• Laboratory of Psychophysiology, Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Science, Warsaw, Poland

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Identyfikatory

DOI

10.21307/ane‑2018‑011