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2009 | 53 | 3 |

Tytuł artykułu

Expression patterns of the viral interleukin 8 among different MDV pathotypes

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of this study was to prove whether the viral interleukin 8 (vIL-8) expression patterns can be studied in vitro among different MDV-1 pathotypes. Minor expression fluctuations were found. The changes in the vIL-8 expression indicated common patterns for the vv+MDV strains as well as for vMDV JM and attenuated Rispens strain. The expression patterns of the two vvMDV strains (Md5 and 549A) were different. The studies presented have shown that the differences in vIL-8 expression, which are important for the cytolytic, productive infection of the cells, can be also investigated in vitro in CEF cultures, but the results should be confirmed by in vivo studies.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

53

Numer

3

Opis fizyczny

p.333-336,fig.,ref.

Twórcy

autor
  • Department of Poultry Viral Diseases, National Veterinary Research Institute, 24-100 Pulawy, Poland
  • Department of Poultry Viral Diseases, National Veterinary Research Institute, 24-100 Pulawy, Poland
  • Department of Poultry Viral Diseases, National Veterinary Research Institute, 24-100 Pulawy, Poland

Bibliografia

  • 1. Calnek B.W., Harris R.W., Buscaglia C., Schat K.A., Lucio B.: Relationship between the immunosuppressive potential and the pathotype of Marek's disease virus isolates. Avian Dis 1998, 42, 124-132.
  • 2. Cortes P.L., Cardona C.J.: Pathogenesis of a Marek's disease virus mutant lacking vIL-8 in resistant and susceptible chickens. Avian Dis 2004, 48, 50-60.
  • 3. Cui X., Lee L.F., Hunt H.D., Reed W.M., Lupiani B., Reddy S.M.: A Marek's disease virus vIL-8 deletion mutant has attenuated virulence and confers protection against challenge with a very virulent plus strain Avian Dis 2005, 49, 199-206.
  • 4. Jarosinski K.W., O'Connell P.H., Schat K.A.: Impact of deletions within the Bam HI-L fragment of attenuated Marek's disease virus on vIL-8 expression and the newly identified transcript of open reading frame LORF4. Virus Genes 2003, 26, 255-269.
  • 5. Jarosinski K.W., Yunis R., O'Connell P.H., Markowski- Grimsrud C.J., Schat K.A.: Influence of genetic resistance of the chicken and virulence of Marek's disease virus (MDV) on nitric oxide responses after MDV infection. Avian Dis 2002, 46, 636-649.
  • 6. Kim D.H., Ko D.S., Lee H.C., Lee H.J., Park W.I., Kim S.S., Park J.K., Yang B.C., Park S.B., Chang W.K., Lee H.T.: Comparison of maturation, fertilization, development, and gene expression of mouse oocytes grown in vitro and in vivo. J Assist Reprod Genet 2004, 21, 233-240.
  • 7. Król K., Petherbridge L., Nair V., Kozdruń W., Samorek- Salamonowicz E.: Molecular characterisation of the vIL8 gene of Polish MDV strains. Medycyna Wet 2008, 64, 804-806.
  • 8. Król K., Samorek-Salamonowicz E., Kozdruń W.: Molecular characteristic of Marek's disease virus genes and peptides. Post Mikrobiol 2005, 44, 351-356.
  • 9. Liu X., Inlow M., Van Etten H. D.: Expression profiles of pea pathogenicity (PEP) genes in vivo and in vitro, characterization of the flanking regions of the PEP cluster and evidence that the PEP cluster region resulted from horizontal gene transfer in the fungal pathogen Nectria haematococca. Curr Genet 2003, 44, 95-103.
  • 10. Morrow C., Fehler F.: Marek's disease a worldwide problem. Marek's Disease. An evolving problem. In: Marek's Disease: An Evolving Problem. Edited by F. Davison and V. Nair, Elsevier Academic Press, London, 2004, pp. 49-61.
  • 11. Nair V.: Evolution of Marek's disease-a paradigm for incessant race between the pathogen and the host. Vet J 2005, 170, 175-183.
  • 12. Parcells M.S., Lin S.F., Dienglewicz R.L., Majerciak V., Robinson D.R., Chen H.C., Wu Z., Dubyak G.R., Brunkovskis P., Hunt H.D., Lee L.F., Kunh H-J.: Marek's disease virus (MDV) encodes an interleukin-8 homolog (vIL-8): Characterization of the vIL-8 protein and a vIL- 8 deletion mutant MDV. J Virol 2001, 75, 5159-5173.
  • 13. Saif Y.M., Barnes H.J., Guisson J.R., Fadly A.M., McDougland L.R., Swayne D.E.: Diseases of poultry. 12th Edition, Blackwell Publishing, Oxford, UK, 2008, pp. 407-446.
  • 14. Schat K.A., Purchase H.G.: Cell-culture methods. In: A laboratory manual for the isolation and identification of avian pathogens, edited by Swayne D.E., Glisson J.R., Jackwood M.W., Pearson J.E., Reed W.M. American Association of Avian Pathologists, Pennsylvania, USA, 1998, pp. 223- 234.
  • 15. Schat K.A., Xing Z.: Specific and nonspecific immune responses to Marek's disease virus. Dev Comp Immunol 2000, 24, 201-221.
  • 16. Shaw K.L., Pepper K., Petersen D., Kaartinen V., Kohn D.B.: In vitro and in vivo gene expression of lentiviral vectors in CD4+ T cells. Mol Therapy 2002, 11, 37.
  • 17. Witter R.L.: Increased virulence of Marek's disease virus field isolates. Avian Dis 1997, 41, 149-163.
  • 18. Xing Z., Schat K.A.: Expression of cytokine genes in Marek's disease virus-infected chickens and chicken embryo fibroblast cultures. Immunology 2000, 100, 70-76.
  • 19. Zelnik V.: Diagnostics of Marek's disease. In: Marek's Disease. An Evolving Problem. Edited by Davison F., Nair V., Elsevier Academic Press, Compton, UK, 2004, pp. 156-165.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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