Triterpenoid alpha-amyrin stimulates proliferation of human keratinocytes but does not protect them against UVB damage

• Autorzy: Biskup E. , Golebiowski M. , Gniadecki R. , Stepnowski P. , Lojkowska E.
• Języki publikacji: EN

Abstrakty

EN

Rhaponticum carthamoides plants ("maral root") are widely used in Siberian folk medicine. The present study reports for the first time the presence of pentacyclic terpenoid, α-amyrin, in methanol extract from leaves of this plant. α-Amyrin induced proliferation of human keratinocytes (HaCaT) by about 18% while other extract components were ineffective. A panel of biochemical and cell-based assays testing the antioxidative and cytoprotective activites of α-amyrin indicated no antioxidative activity of this compound. α-Amyrin did not protect HaCaT cells against the damage caused by UVB radiation.

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2012
• Tom: 59
• Numer: 2
• Opis fizyczny: p.255-260,fig.,ref.

Twórcy

autor

Biskup E.

• Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark

autor

Golebiowski M.

autor

Gniadecki R.

autor

Stepnowski P.

autor

Lojkowska E.

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