Leukotrienes in mucosal damage and protection

• Autorzy: Peskar B.M.
• Języki publikacji: EN

Abstrakty

EN

Exposure of the rat gastric mucosa to ethanol stimulates the generation of leukotriene (LTC₄) and 15-hydroxyeicosatetraenoic acid, hut not of thromboxanes and prostaglandins. Lipoxygenase activation is not found with other topical irritants or nonsteroidal anti-inflammatory drugs. A number of gastroprotective drugs dose-dependently inhibit the stimulatory action of ethanol on mucosal LTC₄ formation closely parallel to their protective activity suggesting that ethanol-induced damage and activation of lipoxygenases may involve common targets which are simultaneously counteracted by certain types of protective agents. Selective inhibition of 5-lip- oxygenase, however, does not confer protection against gastric mucosal damage caused by topical irritants or non-steroidal anti-inflammatory drugs. Thus, although leukotrienes may mediate certain reactions elicited by gastric ulcerogens such as submucosal venular constriction and mucosal micro vascular engorgement, they do not appear to be major mediators of ulcerogen-induced tissue necrosis. The contribution of other products of the various pathways of arachidonic acid metabolism to gastric mucosal injury and the mechanism underlying the close interrelationship between protection and inhibiton of LTC₄ formation observed with certain compounds remains to be investigated.

Słowa kluczowe

EN

gastric mucosa; rat; leukotriene; 15-hydroxyeicosatetraenoic acid; lipoxygenase; gastroprotective drug; nonsteroidal antiinflammatory drug; gastric mucosal protection; indomethacin

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1991
• Tom: 42
• Numer: 2
• Opis fizyczny: p.135-145,fig.,ref.

Twórcy

autor

Peskar B.M.

• Departament of Experimental Clinical Medicine, Ruhr-University of Bochum, Universitalsstresse 150, D-4630 Bochum, Germany

Bibliografia

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