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2018 | 27 | 3 |

Tytuł artykułu

Heptoprotective role of Artemisia scoparia Waldst. and kit against CCl4-induced toxicity in rats

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In this study, the methanol extract of Artemisia scoparia was evaluated for its protective potential against carbon tetrachloride (CCl₄)-induced hepatic toxicity. Seven groups of mature albino rats were used in the course of the experiment and each group was treated with specific doses of plant extract and CCl₄. Silymarin was used as a standard protective drug. The results of the experiment revealed that Artemisia scoparia plant extract was successful in fighting CCl₄ toxicity as it clearly reduced the elevated levels of liver serum markers (alkaline phosphatase and alkaline aminotransferase), lipid peroxidation, nitrite content, and H₂O₂ on one side while enhancing the levels of antioxidant enzymes (catalase, peroxidase, superoxide dismutase, glutathione-s-transferase, γ-Glutamyltranspeptidase, and glutathione reductase) and protein content. It also protected DNA from the damaging effects of CCl₄. The findings of this study demonstrate that Artemisia scoparia plant extract plays a significant role in preventing the hepatic damages instigated with CCl₄ and can be used as a protective agent against oxidative stress-associated disorders.

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  • Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan
  • Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan
  • Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
  • School of Ecology and Environmental Science, Yunnan University, No. 2 North Cuihu Road, Kunming, Yunnan, 650091, P.R. China
  • Yunnan institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, P.R. China
  • School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, District Minhang Shanghai, China
  • School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, District Minhang Shanghai, China
  • Shaheed Benazir Bhutto University, Sheringal, KP, Pakistan
  • 7 Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xian 710069, P.R. China
  • Department of Botany, Bacha Khan University Charsadda, Pakistan
  • Key Laboratory of Molecular Epigenetics, Ministry of Education, School of Life Sciences, Northeast Normal University, Changchun, 130024, Jilin, P.R. China
  • 1School of Resources, Environmental and Chemical Engineering Nanchang University, Nanchang Jiangxi, P.R. China


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