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2008 | 68 | 3 |
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Nigrostriatal projecting neurons express GDNF receptor subunit RET in adult rats

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Języki publikacji
EN
Abstrakty
EN
Nigrostriatal neurons expressing RET protein, a receptor protein tyrosine kinase of glial cell line-derived neurotrophic factor (GDNF), were investigated in rats using retrograde neural tracing with horseradish peroxidase (HRP) combined with immunohistochemistry. HRP/RET double-labeled neurons were abundantly distributed in the substantia nigra pars compacta ipsilateral to the caudate-putamen stereotaxically injected with HRP. Almost all the HRP-labeled neurons in nigra exhibited RET-like immunoreactivity, which however constituted more than half of the RET-immunoreactive cells. Our results present morphological evidence that GDNF-RET interaction plays important roles in physiological processes of nigrostriatal neuronal circuits of mammals.
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-
Rocznik
Tom
68
Numer
3
Opis fizyczny
p.347-353,fig.,ref.
Twórcy
autor
  • Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xian, People's Republic of China
autor
  • Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xian, People's Republic of China
autor
  • Institute of Medical Sciences, University of Aberdeen, Aberdeen, U.K.
autor
  • Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xian, People's Republic of China
autor
  • Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xian, People's Republic of China
autor
  • Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xian, People's Republic of China
autor
  • Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xian, People's Republic of China
Bibliografia
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PL
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
bwmeta1.element.agro-8dc84019-efaf-42df-b53b-02df67cc871d
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