Bioelectrical activity of the amygdala of rats under conditions of chronic alcoholism and imbalance of nitric oxide

• Autorzy: Severynovska O. , Babicheva V. , Galinskiiy A. , Rudenko A. , Bogatyreva O. , Boyko M.
• Języki publikacji: EN

Abstrakty

EN

Evaluation of biopotentials in the region of the amygdala of rats in the combined influence of alcohol and drugs, causing an imbalance of nitric oxide is described in this paper. Chronic alcoholism leads to structural morphological changes in the liver. A study of the amplitude of electrical activity showed that the electrical potential in the amygdala after 8 weeks chronic alcoholism was lower compared with normal rats. The frequency spectrum analysis showed decreased in the 2 times or more absolute spectral powers of all components. The relative spectral powers of its components: δ: θ: α: β was as a 2: 2: 2: 4. The use of sodium nitroprusside (donator of NO) together with the chronic consumption of ethanol reduces the effect of ethanol on low and high-frequence portion the performance of the bioelectrical activities spectrum in the amygdala. The use of non-selective blocker of NO-synthase – nitroarginine aggravated by the braking action of alcohol. The important role of nitric oxide in the development of adaptive-compensatory reactions of the damaged body is described. Our results may be useful to assess the contribution of NO in operation amygdala, conditions of chronic pathologies, and treatment of neuropsychiatric conditions, including diseases caused by alcohol abuse.

Słowa kluczowe

EN

amygdala; bioelectrical activity; nitric oxide; chronic alcoholism; sodium nitroprusside; nitro-L-arginine; aminoguanidine; rat experiment

• Wydawca: -
• Czasopismo: International Letters of Natural Sciences
• Rocznik: 2015
• Tom: 49
• Opis fizyczny: p.22-27,fig.,ref.

Twórcy

autor

Severynovska O.

• Oles Honchar Dnipropetrovsk National University, Ukraine

autor

Babicheva V.

• Oles Honchar Dnipropetrovsk National University, Ukraine

autor

Galinskiiy A.

• Oles Honchar Dnipropetrovsk National University, Ukraine
• Dnipropetrovsk Gastroenterology Institute, Ukrainian Academy of Medical Sciences, Ukraine

autor

Rudenko A.

• Dnipropetrovsk Gastroenterology Institute, Ukrainian Academy of Medical Sciences, Ukraine

autor

Bogatyreva O.

• University of Bath, BioTRIZ Ltd, UK

autor

Boyko M.

• Soroka University Medical Center, Israel

Bibliografia

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• DOI References
• [1] F. Campagna, S. Montagnese, S. Schiff, M. Ruzzoli, Confounders in the detection of minimal hepatic encephalopathy: a neuropsychological and quantified EEG study, Liver Int., 35(5) (2015): 1524-1532. 10.1111/liv.12635
• [2] A.D. Dager, D.R. McKay, J. W Jr Kent, J.E. Curran, Shared genetic factors influence amygdala volumes and risk for alcoholism, Neuropsychopharmacology. 40(2) (2015) 412-420. 10.1038/npp.2014.187
• [4] J.L. Kissler,S. Sirohi, D.J. Reis, H.T. Jansen, R.M. Quock, D.G. Smith, B.M. Walker, The onetwo punch of alcoholism: role of central amygdala dynorphins/kappa-opioid receptors, Biol Psychiatry. 75(10) (2014) 774-782. 10.1016/j.biopsych.2013.03.014
• [5] O. A Lyubashina, A. A Dorofeeva, E.B. Pluzhnichenko, S.S. Panteleev, Location of neurons in the central nucleus of the amygdaloid body projecting to the paraventricular nucleus of the hypothalamus. Neurosci Behav Physiol. 40(1) (2010) 103-105. 10.1007/s11055-009-9218-3
• [6] O.A. Lyubashina, A.D. Nozdrachev, NO-dependent mechanisms of amygdalocortical influence, Dokl Biol Sci. 421 (2008) 225-228. 10.1134/s0012496608040017
• [7] Y.S. Nikolova, A.R. Knodt, S.R. Radtke, A.R. Hariri, Divergent responses of the amygdala and ventral striatum predict stress-related problem drinking in young adults: possible differential markers of affective and impulsive pathways of risk for alcohol use disorder, Mol Psychiatry. (2015). 10.1038/mp.2015.85
• [9] R.M. Sears, H.C. Schiff, J.E. LeDoux, Molecular mechanisms of threat learning in the lateral nucleus of the amygdala, Prog Mol Biol Transl Sci. 122 (2014) 263-304. 10.1016/b978-0-12-420170-5.00010-6
• [11] F.Z. Shaw, R.F. Chen, H.W. Tsao, C.T. Yen, A multichannel system for recording and analysis of cortical field potentials in freely moving rats, J Neurosci Methods. 88(1) (1999) 33-43. 10.1016/s0165-0270(99)00010-2
• [12] H. Schweighöfer,C. Rummel, K Mayer, B. Rosengarten, Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shock, Intensive Care Med Exp. 2(1) (2014) 1-9. 10.1186/s40635-014-0024-z
• [14] N.M. Zahr, Structural and microstructral imaging of the brain in alcohol use disorders. Handb Clin Neurol. 125 (2014) 275-290.10.1016/b978-0-444-62619-6.00017-3

Identyfikatory

DOI

10.18052/www.scipress.com/ILNS.49.22