Protective role of silibinin over nickel sulfate-induced reproductive toxicity in male rats

• Autorzy: Temamogullari F. , Atessahin A. , Cebi Sen C. , Yumusak N. , Dogru M.S.
• Języki publikacji: EN

Abstrakty

EN

Nickel damages the male reproductive system. We investigated the beneficial effects of silibinin which has metal-chelating and antioxidant properties over nickel toxicity. Both antioxidative effects in testes and overall effects related to sperm motility, membrane and acrosome integrity of orally administered Silibinin were evaluated against the harmful effects of 30 day of intraperitoneal nickel sulfate (5 mg/kg/day) administration in rats. Male rats were randomized into control (Group1; n=6) and three experimental groups (n=6, each): Group2 Nickel sulfate (5 mg/kg/day), Group3 Silibinin (150 mg/kg/day), and Group 4 Nickel sulfate (5 mg/kg/day) + Silibinin (150 mg/kg/day). We found higher sperm motility, viable sperm and total sperm count in Groups 3 and 4 than the Group 2 treatment groups and the percentage of abnormal spermatozoa was similar in both groups (Groups 2 and 4). Increased apoptosis, activation of caspase3, 8, 9 and TUNEL were detected in Group 2. However, activation of caspase3, 8, 9 and TUNEL was reduced in Group 4. The protective effects of silibinin were demonstrated on histopathologic findings and some sperm parameters (sperm motility percentage, viable spermatozoa, sperm count, and abnormal spermatozoa percentage) in rats exposed to nickel.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2021
• Tom: 24
• Numer: 1
• Opis fizyczny: p.29-34,fig.,ref.

Twórcy

autor

Temamogullari F.

• Department of Pharmacology and Toxicology, University of Harran, Faculty of Veterinary Medicine, 63200 Sanliurfa, Turkey

autor

Atessahin A.

• Department of Pharmacology and Toxicology, University of Firat, Faculty of Veterinary Medicine, 23119 Elazig, Turkey

autor

Cebi Sen C.

• Department of Reproduction and Artificial Insemination, University of Harran, Faculty of Veterinary Medicine, 63200 Sanliurfa, Turkey

autor

Yumusak N.

• Department of Pathology, University of Harran, Faculty of Veterinary Medicine, 63200 Sanliurfa, Turkey

autor

Dogru M.S.

• Department of Pharmacology and Toxicology, University of Aksaray, Faculty of Veterinary Medicine, 6800 Aksaray, Turkey

Identyfikatory

DOI

10.24425/pjvs.2020.135817