EN
On the basis of the phenazone test there was assessed the influence of water limitation given to animals on the biotransformable activity of the liver in 9 male calves, Low-land breed, aged from 42 to 45 days. It was found that water limitation had a little effect on the phenazone distribution in the organism (Vd) of animals. In contrast, it was stated a statistically significant decrease of phenazone clearance (T/2) and lowered metabolic values of phenazone clearance (СA) in the experimental group. A diminished capacity of calves’ liver to transform exogenic substances dropped slowly and only at 96 hours after water limitation a decreased volume T/2 and CA were statistically significant.