Vasopressin release in response to hypovolaemia in the conscious rat and the effect of opioid and aminergic receptor antagonists

• Autorzy: Peysner K. , Forsling M. L.
• Języki publikacji: EN

Abstrakty

EN

Conscious rats were given i. p. polyethylene glycol (PEG) or dextran injections to compare their efficacy in inducing moderate hypovolaemia. Dextran was found unsuitable, producing large variability in the the plasma vasopressin (A VP) concentrations. Putative neurotransmitters involved in the A VP response to hypovolaemia and in basal release were examined using opioid, and ß-adrenoceptor and dopamine receptor-blocking agents. A dose of PEG was chosen to produce a decrease in blood volume of approx 14.5% giving plasma AVP concentrations of 19.0±4.6 pmol/1. Naloxone and phenoxy- benzamine failed to influence AVP release under both hypovolaemic and basal conditions. Prazosin also failed to influence the AVP response. In contrast propranolol elevated the plasma AVP concentrations in both conditions. Haloperidol enhanced basal AVP release but did not influence release during hypovolaemia. Guanethidine pretreatment partially blocked the response to hypovolaemia, but did not affect basal plasma AVP. Thus it appears that aminergic pathways have an inhibitory influence on AVP release under hypovolaemic and basal conditions. However, endogenous opioids do not appear to contribute significantly to the hypovolaemic response.

Słowa kluczowe

EN

vasopressin; opioid peptide; catecholamine; hypovolemia; rat; polyethylene glycol; dextran; beta-adrenoceptor; dopamine receptor

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1991
• Tom: 42
• Numer: 3
• Opis fizyczny: p.317-326,fig.,ref.

Twórcy

autor

Peysner K.

• Department of Gynaecology, UMDS, St. Thomas' Campus, Lambeth Palace Road, London, SEI 7EH, U.K.

autor

Forsling M. L.

• Department of Gynaecology, UMDS, St. Thomas' Campus, Lambeth Palace Road, London, SEI 7EH, U.K.

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