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2017 | 35 | 2 |
Tytuł artykułu

Adrenocorticotrophic hormone and cortisol levels during late pregnancy and post-foaling period in mares

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
The aim of this study was to evaluate the trend of adrenocorticotrophic hormone (ACTH) and cortisol levels in mares during peripartum period. Twelve pregnant mares (Group A) were weekly monitored from the last 6 weeks before foaling (6BF-1BF) until the first 3 weeks after foaling (1AF-3AF). Twelve non-pregnant non-lactating mares constituted the control (Group B). Jugular blood samples were analyzed for plasma ACTH and serum cortisol concentration. ACTH showed higher values (P<0.05) at 1BF compared to the postpartum data points (1AF, 2AF and 3AF) in Group A. Cortisol levels were higher (P<0.05) at 1BF and 2BF compared to the 3AF in Group A. A significant positive correlation between ACTH and cortisol values was found in mares from Group A throughout the peripartum period (Pearson’s r=0.40; P=0.0028). The Dunnet’s test showed lower ACTH values in Group A at postpartum data points than control, and higher cortisol levels in Group A throughout prepartum times and at 1AF than control (P<0.0001). The decrease of ACTH and cortisol levels found during the early postpartum period could indicate a reduced HPA response to physical and/or psychological stress during this physiological phase. This could help the mare to protect against stress-associated inhibition of lactation, relieve psychological stress, and enhance her immune function. Further studies involving the evaluation of prolactin and sex steroid hormones values are needed to fully understand the dynamic hormonal changes occurring in pregnant and lactating mares in order to permit clinicians to make appropriate interpretation of the results.
Wydawca
-
Rocznik
Tom
35
Numer
2
Opis fizyczny
p.173-180,fig.,ref.
Twórcy
autor
  • Department of Veterinary Sciences, University of Messina, Polo Universitario del Annunziata, 98168, Messina, Italy
autor
  • Department of Veterinary Sciences, University of Messina, Polo Universitario del Annunziata, 98168, Messina, Italy
autor
  • Department of Veterinary Sciences, University of Messina, Polo Universitario del Annunziata, 98168, Messina, Italy
autor
  • Department of Veterinary Sciences, University of Messina, Polo Universitario del Annunziata, 98168, Messina, Italy
autor
  • Department of Veterinary Sciences, University of Messina, Polo Universitario del Annunziata, 98168, Messina, Italy
autor
  • Department of Veterinary Sciences, University of Messina, Polo Universitario del Annunziata, 98168, Messina, Italy
autor
  • Department of Veterinary Sciences, University of Messina, Polo Universitario del Annunziata, 98168, Messina, Italy
Bibliografia
  • 1. ARFUSO F., GIANNETTO C., RIZZO M., FAZIO F., GIUDICE E., PICCIONE G., 2016 - Serum levels of mitochondrial uncoupling protein 1, leptin, and lipids during late pregnancy and the early postpartum period in mares. Theriogenology 86, 1156 - 1164.
  • 2. BAZZANO M., GIANNETTO C., FAZIO F., ARFUSO F., GIUDICE E., PICCIONE G., 2014a Metabolic profile of broodmares during late pregnancy and early post-partum. Reproduction in Domestic Animals 49, 947 - 953.
  • 3. BAZZANO M., GIANNETTO C., FAZIO F., RIZZO M., GIUDICE E., PICCIONE G., 2014b - Physiological adjustments of haematological profile during the last trimester of pregnancy and the early postpartum period in mares. Animal Reproduction Science 149, 199 - 203.
  • 4. BAZZANO M., GIANNETTO C., FAZIO F., MARAFIOTI S., GIUDICE E., PICCIONE G., 2014c Hemostatic profile during late pregnancy and early postpartum period in mares. Theriogenology 81, 639 - 643.
  • 5. BAZZANO M., ARFUSO F., GIUDICE E., DI PIETRO S., PICCIONE G., 2015 - Platelet aggregation percentage increased in healthy broodmares during the peripartum. Journal of Equine Veterinary Science 35, 573 - 576.
  • 6. BERG E. L., MCNAMARA D. L., KEISLER D. H., 2007 - Endocrine profiles of periparturient mares and their foals. Journal of Animat Science 85, 1660 - 1668.
  • 7. BONELLI F., ROTA A., CORAZZA M., SERIO D., SGORBINI M., 2016 - Hematological and biochemical findings in pregnant, postfoaling, and lactating jennies. Theriogenology 85, 1233 - 1238.
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  • 19. MASTORAKOS G., ILIAS I., 2003 - Maternal and fetal Hypothalamic-Pituitary-Adrenal Axes during pregnancy and postpartum. Annals of the New York Academy of Sciences 997, 136 - 149.
  • 20. MEANEY M. J., SZYF M., SECKL J. R., 2007 - Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health. Trends in Molecular Medicine 13, 269 - 277.
  • 21. MEINLSCHMIDT G., MARTIN C., NEUMANN I. D., HEINRICHS M., 2010 - Maternal cortisol in late pregnancy and hypothalamic-pituitary-adrenal reactivity to psychosocial stress postpartum in women. Stress 13(2), 163 - 171.
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  • 23. NEUMANN I. D., KROMER S. A., BOSCH O. J., 2005 - Effects of psycho-social stress during pregnancy on neuroendocrine and behavioural parameters in lactation depends on the genetically determined stress vulnerability. Psychoneuroendocrinology 30, 791 - 806.
  • 24. OUSEY J. C., 2004 - Peripartal endocrinology in the mare and foetus. Reproduction in Domestic Animals 39, 222 - 231.
  • 25. PHILLIPS D. I., 2007 - Programming of the stress response: A fundamental mechanism underlying the long-term effects of the fetal environment? Journal of Internal Medicine 261, 453 - 460.
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  • 27. SATUÉ K., DOMINGO R., MUŃOZ A., 2007 - Serum cortisol concentrations in Spanish mares during pregnancy. Ippologia 18(3), 21 - 25.
  • 28. SATUÉ K., DOMINGO R., REDONDO J. I., 2011 - Relationship between progesterone, oestrone sulphate and cortisol and the components of renin angiotensin aldosterone system in Spanish purebred broodmares during pregnancy. Theriogenology 76, 1404 - 1415.
  • 29. SILVER M., FOWDEN A. L., 1994 - Prepartum adrenocortical maturation in the fetal foal: responses to ACTH. Journal of Endocrinology 142, 417 - 425.
  • 30. TAYLOR R. N., BADELL M. L., 2001 -The endocrinology of pregnancy. In: Gardner D. G., Shoback D. eds. Greenspan’s basic and clinical endocrinology. Prentice Hall, Hartford, CT, pp. 575 - 602.
  • 31. TORNER L., TOSCHI N., NAVA G., CLAPP C., NEUMANN I. D., 2002 - Increased hypothalamic expression of prolactin in lactation: involvement in behavioral an neuroendocrine stress responses. European Journal of Neuroscience 15, 1381 - 138.
Typ dokumentu
Bibliografia
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Identyfikator YADDA
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