Effect of levetiracetam on penicillin induced epileptic activity in rats

• Autorzy: Arik A.E. , Bagirici F. , Sefil F. , Marangoz C.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to investigate the effects of levetiracetam (LEV) on penicillin- induced epileptiform activity in rats. Penicillin was applied intracerebroventricularly (icv) at a dose of 500 IU to induce epileptiform activity. LEV was given intraperitoneally (ip) at doses of 20, 40, 80 mg/kg before penicillin injection. This agent reduced epileptiform activity by decreasing spike frequencies. The mean spike frequencies decreased significantly in all the LEV treated groups. There was no significant change in the spike amplitudes of the LEV groups compared with the control group. 40 mg/kg of LEV was determined as the most effective dose on reducing epileptiform activity. The results of this study suggest that LEV is an effective antiepileptic agent in penicillin-induced epilepsy.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.266-275,fig.,ref.

Twórcy

autor

Arik A.E.

• Hospital of Teaching and Research, Samsun, Turkey

autor

Bagirici F.

• Department of Physiology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey

autor

Sefil F.

• Department of Physiology, Mustafa Kemal University, Faculty of Medicine, Hatay, Turkey

autor

Marangoz C.

• Department of Physiology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey

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