The influence of vanadium (V) on the ultrastructure of hepatocytes of the Rat Liver

• Autorzy: Kopacz-Bednarska A. , Krol T. , Zaporowska H. , Trybus E. , Trybus W.
• Języki publikacji: EN

Abstrakty

EN

Vanadium is an element which shows a multidirectional mechanism of action, it has a positive influence on the physiological and biochemical processes of the body, however at high concentrations it can show toxic properties. For that reason it is important to assess the influence of a specific dose and action time of vanadium on the morphological profile of rat hepatocytes. The purpose of this research was to evaluate the changes in ß-D-glucuronidase activity and the ultrastructural profile of rat hepatocytes subject to 18 weeks of sodium metavanadate in the concentration of 0,125 mg V ml"1. The experimental animals were 2-month-old male Wistar rats. The biochemical analysis was done based on the distribution of synthetic substrates using a spectrophotometric method. The biochemical research results revealed a statistically significant reduction in the activity of ß-D-glucuronidase (ß-Gr) in the liver cells of experimental animals. The submicroscopic assessment of the cells was performed with the use of a transmission electron microscope. In the ultrastructural image of the hepatocytes of experimental animals, changes associated mainly with mitochondria, the lysosomal system and peroxisomes were observed.

• Wydawca: -
• Czasopismo: Acta Biologica Cracoviensia. Series Zoologia
• Rocznik: 2012
• Tom: 54
• Opis fizyczny: p.19-24,fig.,ref.

Twórcy

autor

Kopacz-Bednarska A.

• Department of Cell Biology, Institute of Biology, The Jan Kochanowski University, Swietokrzyska 15, 25-406 Kielce, Poland

autor

Krol T.

• Department of Cell Biology, Institute of Biology, The Jan Kochanowski University, Swietokrzyska 15, 25-406 Kielce, Poland

autor

Zaporowska H.

• Department of Cell Biology, Institute of Environmental Protection, The John Paul II Catholic University in Lublin, Krasnicka 102, 20-718 Lublin, Poland

autor

Trybus E.

• Department of Cell Biology, Institute of Biology, The Jan Kochanowski University, Swietokrzyska 15, 25-406 Kielce, Poland

autor

Trybus W.

• Department of Cell Biology, Institute of Biology, The Jan Kochanowski University, Swietokrzyska 15, 25-406 Kielce, Poland

Uwagi

PL

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