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2015 | 71 | 10 |

Tytuł artykułu

Rola wielonienasyconych kwasów tłuszczowych omega-3 w przebiegu zapaleń

Autorzy

Warianty tytułu

EN
Role of omega-3 polyunsaturated fatty acids in the course of inflammatio

Języki publikacji

PL

Abstrakty

EN
Omega-3 polyunsaturated fatty acids, especially their long-chain form: eicosapentaenoic acid EPA and docosahexaenoic acid DHA have beneficial effects on animal and human health. Many studies indicate that the health promoting activity of these acids is to a large extent related to the regulation and resolving of the inflammatory process. Inflammation promotes many diseases, including arteriosclerosis, infections, autoimmune diseases, cancer, or neurodegenerative disorders. The beneficial health effects of omega-3 fatty acids results from the activity their metabolites, especially resolvins and protectins. The purpose of this paper was to present the mechanism of omega-3 fatty acids anti-inflammatory action.

Wydawca

-

Rocznik

Tom

71

Numer

10

Opis fizyczny

s.608-614,rys.,tab.,bibliogr.

Twórcy

  • Katedra Dietetyki i Oceny Żywności, Instytut Nauk o Zdrowiu, Uniwersytet Przyrodniczo-Humanistyczny w Siedlcach, ul. Konarskiego 2, 08-110 Siedlce

Bibliografia

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  • 2. Arita M., Bianchini F., Aliberti J., Sher A., Chiang N., Hong S., Yang R., Petasis N. A., Serhan C. N.: Stereochemical assignment, anti-inflammatory properties, and receptor. J. Exp. Med. 2005, 201, 713-722.
  • 3. Arterburn L. M., Bailey Hall E., Oken H.: Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am. J. Clin. Nutr. 2006, 83, S1467-S1476.
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  • 10. Goyens P. L., Spilker M. E., Zock P. L., Katan M. B., Mensink R. P.: Compartmental modeling to quantify alpha-linolenic acid conversion after longer-term intake of multiple tracer boluses. J. Lipid Res. 2005, 46, 1474-1483.
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  • 12. Karin M., Greten F. R.: NF-kappaB: linking inflammation and immunityto cancer development and progression. Nat. Rev. Immunol. 2005, 5, 749-759.
  • 13. Kohli P., Levy B. D.: Resolvins and protectins: mediating solutions to inflammation. Br. J. Pharmacol. 2009, 158, 960-971.
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  • 15. Kris-Etherton P. M., Hill A.: n-3 fatty acids: food or supplements? J. Am. Diet. Assoc. 2008, 108, 1125-1130.
  • 16. Maderna P., Godson C.: Lipoxins: resolutionary road. Br. J. Pharmacol. 2009, 158, 947-959.
  • 17. Massaro M., Scoditti E., Carluccio M. A., DeCaterina R.: Basic mechanisms behind the effects of n-3 fatty acids on cardiovascular disease. Prostagl. Leukotr. Essent. Fatty Acids 2008, 79, 109-115.
  • 18. Mori T., Burke V., Puddey I., Watts G., O’Neal D., Best J., Beilin L.: Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am. J. Clin. Nutr. 2000, 71, 1085-1094.
  • 19. Pawlosky R. J., Hibbeln J. R., Novotny J. A., Salem N.: Physiological compartmental analysis of α-linolenic acid metabolism in adult humans. J. Lipid Res. 2001, 42, 1257-1265.
  • 20. Poulsen R. C., Gotlinger K. H., Serhan C. N., Kruger M. C.: Identification of inflammatory and proresolving lipid mediators in bone marrow and their lipidomic profiles with ovariectomy and omega-3 intake. Am. J. Hematol. 2008, 83, 437-445.
  • 21. Ratnayake W., Galli C.: Fat and fatty acid terminology, methods of analysis and fat digestion and metabolism: a background review paper. Ann. Nutr. Metab. 2009, 55, 8-43.
  • 22. Schwab J. M., Chiang N., Arita M., Serhan C. N.: Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature 2007, 447, 869-874.
  • 23. Seki H., Tani Y., Arita M.: Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1. Prostagl. Lipid Mediators 2009, 89, 126-130.
  • 24. Serhan C. N.: Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins. Curr. Opin. Clin. Nutr. Metab. Care 2005, 8, 115-121.
  • 25. Serhan C. N.: Systems approach to inflammation resolution: identification of novel anti-inflammatory and pro-resolving mediators. J. Thromb. Haemost. 2009, 7, S44-S48.
  • 26. Serhan C. N., Yang R., Martinod K., Kasuga K., Pillai P., Porter T., Oh S., Spite M.: Maresins: novel macrophage mediators with potent anti inflamatory and proresolving actions. J. Exp. Med. 2008, 206, 15-23.
  • 27. Simopoulos A. P.: The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp. Biol. Med. 2008, 233, 674-688.
  • 28. Spite M., Summers L., Porter T. F., Srivastava S., Bhatnagar A., Serhan C. N.: Resolvin D1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress. Br. J. Pharmacol. 2009, 158, 1062-1073.
  • 29. Rutkowski R., Pancewicz S. A., Skrzydelska E., Hermanowska-Szpakowicz T.: Właściwości biologiczne czynnika transkrypcji jądrowej NF-κB. Alegria Astma Immunol. 2005, 10, 125-131.
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Typ dokumentu

Bibliografia

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