Antioxidant and free radical scavenging effect of D-carvone in hypertensive rats. In vivo and in vitro study

• Autorzy: Rajeshwari T. , Raja B.
• Języki publikacji: EN

Abstrakty

EN

This study was planned to assess the antioxidant and free radical scavenging effect of D-carvone against L-NAME (Nω-nitro-L-arginine methyl ester hydrochloride) induced hypertension. Hypertension was encouraged in adult male albino rats of the Wistar strain, considering 180–230 g, by oral administration of the L-NAME (40 mg/kg/ body weight/day) in drinking water for 4 weeks. Rats were cured with D-carvone (5, 10 and 20 mg/kg body weight) for four weeks. A significant reduction in the levels of non-enzymatic antioxidants such as vitamin C, vitamin E and reduced glutathione (GSH), in plasma were perceived in L- NAME induced hypertensive rats. Moreover, in vitro free radical scavenging activity of ABTS+ and DPPH• radical scavenging possible of D-carvone was also quantified. Treatment with D-carvone (5, 10 and 20 mg/kg bw) carries back all the above parameters to near usual level, in which 20 mg/kg displayed the highest effect than that of other two doses. Further, D-carvone displays concentration dependent antioxidant potential. These results suggest that D-carvone acts as an antioxidant and free radical scavenging agent against L-NAME induced hypertension.

Słowa kluczowe

EN

D-carvone; antioxidant; free radical; scavenging; hypertensive rat; in vitro study; in vivo study

• Wydawca: -
• Czasopismo: International Letters of Natural Sciences
• Rocznik: 2015
• Tom: 08
• Opis fizyczny: p.6-12,fig.,ref

Twórcy

autor

Rajeshwari T.

• Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India

autor

Raja B.

• Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India

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