Intravaginal administration of sildenafil citrate increases blood flow in the bovine uterus

• Autorzy: Dzieciol M. , Noszczyk-Nowak A. , Michlik K. , Nizanski W. , Dejneka G.
• Języki publikacji: EN

Abstrakty

EN

The aim of the studx was to evaluate the influence of sildenafil citrate administrated intravaginaly on the blood flow in the bovine uterus during dioestrus. Uterine blood flow was examined in six healthy adult cows. Sildenafil was administrated intravaginaly to each cow between the 6th and 8th d of the ovarian cycle, in the form of vaginal suppositories containing 100 mg of active substance at a dose of 100, 200, or 300 mg per animal. Uterine perfusion was estimated by the colour Doppler examination, and obtained results were analysed with the Pixel Flux Software (Chameleon, Germany). Moreover, cardiovascular parameters were also evaluated. Animals were examined before and five times after drug application (two times at 15 min intervals, and three times at 2 h intervals). A placebo suppository was also given to the cows. The analy sis of the intensity and velocity of blood flow in the uterus proved that sildenafil administrated intravaginaly significantly increased blood flow in the uterus and the effect of increased perfusion was observed for 4 h and 30 min after administration. The effect of increased uterine perfusion was observed after low as well as high doses of sildenafil. Significant changes in the cardiovascular parameters were not detected. There were no changes in the uterine perfusion as well as in cardiovascular parameters after placebo administration.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2015
• Tom: 59
• Numer: 1
• Opis fizyczny: p.91-97,fig.,ref.

Twórcy

autor

Dzieciol M.

• Department of Reproduction and Clinic of Farm Animals, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

autor

Noszczyk-Nowak A.

• Department of Internal and Parasitic Diseases and Clinic for Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

autor

Michlik K.

• Department of Internal and Parasitic Diseases and Clinic for Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

autor

Nizanski W.

• Department of Reproduction and Clinic of Farm Animals, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

autor

Dejneka G.

• Department of Reproduction and Clinic of Farm Animals, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

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Identyfikatory

DOI

10.1515/bvip-2015-0014