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2013 | 60 | 2 |
Tytuł artykułu

A toy model of prebiotic peptide evolution: the possible role of relative amino acid abundances

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
 This paper presents a mathematical-computational toy model based on the assumed dynamic principles of prebiotic peptide evolution. Starting from a pool of amino acid monomers, the model describes in a generalized manner the generation of peptides and their sequential information. The model integrates the intrinsic and dynamic key elements of the initiation of biopolymerization, such as the relative amino acid abundances and polarities, as well as the oligomer reversibility, i.e. fragmentation and recombination, and peptide self-replication. Our modeling results suggest that the relative amino acid abundances, as indicated by Miller-Urey type electric discharge experiments, played a principal role in the early sequential information of peptide profiles. Moreover, the computed profiles display an astonishing similarity to peptide profiles observed in so-called biological common ancestors found in the following three microorganisms; E. coli, M. jannaschii, and S. cereviasiae. The prebiotic peptide fingerprint was obtained by the so-called polarity index method that was earlier reported as a tool for the identification of cationic amphipathic antibacterial short peptides.
Wydawca
-
Rocznik
Tom
60
Numer
2
Opis fizyczny
p.175-182,fig.,ref.
Twórcy
autor
  • Facultad de Ciencias de la Salud, Universidad Anahuac, Huixquilucan Estado de Mexico, Mexico
  • Centro de Investigaciones Quimicas Universidad Autonoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
autor
  • Centro de Investigaciones Quimicas Universidad Autonoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
  • Facultad de Ciencias de la Salud, Universidad Anahuac, Huixquilucan Estado de Mexico, Mexico
  • Facultad de Ciencias de la Salud, Universidad Anahuac, Huixquilucan Estado de Mexico, Mexico
Bibliografia
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  • Mosqueira FG, Negron A, Ramos S, Polanco C (2012) Biased versus unbiased randomness in homo-polymers and copolymers of amino acids in the prebiotic world. Acta Biochim Pol 59: 543-547. 
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  • Polanco C, Samaniego JL (2009) Detection of selective cationic amphipatic antibacterial peptides by Hidden Markov models. Acta Biochim Pol 56: 167-76. 
  • Polanco C, Samaniego JL, Buhse T, Mosqueira FG, Negron-Mendoza A, Ramos-Bernal S, Castañón-González JA (2012) Characterization of selective antibacterial peptides by polarity index. Int J Pept 585027. doi: 10.1155/2012/585027. 
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  • Wang G, Li X, Wang Z (2009) APD2: the updated antimicrobial peptide database and its application in peptide design. Nucleic Acids Res 37: D933-D937 
Typ dokumentu
Bibliografia
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