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1989 | 40 | 5-6 |
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Adipogenic activity in the plasma of genetically obese zucker rats

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Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Sypniewska, G.: Adipogenic activity in the plasma of genetically obese Zucker rats. Acta physiol, pol., 1989, 40(5-6) 520-529. The potential of plasma to stimulate differentiation and lipid filling of adipose precursors in primary culture was investigated in the groups of genetically obese Zucker rats (fafa) and their lean littermates (FaFa). The effect of age, feeding status and possible role of growth hormone in the process of adipogenesis was also studied. Differences in lipid-filling activity of the tested plasma samples were much more dependent on age than the genotype of plasma donors were. The plasma taken from the oldest (20-week-old) rats stimulated the accumulation of triglycerides in the cells to significantly higher levels than the plasma from other rats. The influence of the feeding status on the lipid-filling activity of plasma was not significant. The differentiation potential of plasma in terms of the stimulation of glycerophosphate dehydrogenase activity measured in adipocyte precursors was 30-50% higher when the culture medium contained plasma from obese rats. Furthermore, glycerophosphate dehydrogenase activity in the growing cells declined with age and tended to be higher in the presence of plasma from fed rats. It was the growth hormone that was in a considerable degree responsible for the differentiation potential of Zucker rat plasma. This effect of growth hormone seemed to be less depedent on fafa genotype. It is, therefore, suggested that in addition to growth hormone, other factors in the plasma of genetically obese Zucker rats might be important in the development of obesity in this rat strain.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
40
Numer
5-6
Opis fizyczny
p.520-529,fig.,ref.
Twórcy
  • Clinical Metabolic Laboratory, Sahlgren's Hospital, Department of Medicine, University of Goteborg, Goteborg, Sweden
Bibliografia
  • 1. Björntorp, P., Karlsson, M., Petroft, H., Pettersson, P., Sjöström, L., Smith, U. (1978) Isolation and characterization of cells from rat adipose tissue developing into adipocytes. J. Lipid Res. 19. 316-324.
  • 2. Björntorp, P., Faust, I. M., Miller, Jr. W. H., Karlsson, M., Sypniewska, G., Dahlgren, K. (1985) Dietary and species influence on potential of plasma to stimulate differentiation and lipid accumulation in cultured adipocyte precursors. J. Lipid Res. 26. 1444-1454.
  • 3. Boulange, A., Planche, E., de Gasquet, P. (1979) Onset of obesity in the absence of hyperphagia during the first week of life in the Zucker rats. J. Lipid Res. 20. 857-864.
  • 4. Cleary, M. P., Brasel, J. A., Greenwood, M.R.C. (1979) Developmental changes in thymidine kinase, DNA and fat cellularity in Zucker rats. Am. J. Physiol. 236(5). E508-E513.
  • 5. Deb, S., Martin, R. J., Hershberger, T. V. (1976) Maintenance requirement and energetic efficiency of lean and obese Zucker rats. J. Nutr. 69. 191-197.
  • 6. de Gasquet, P., Pequignot, E., Lemonnier D., Alexiu, A. (1973) Adipose tissue lipoprotein lipase activity and cellularity in the genetically obese Zucker rat (fafa). Biochem. J. 132. 633-635.
  • 7. Gruen, R. K., Hietanen, E., Greenwood, M. R. C. (1978) Increased adipose tissue lipoprotein activity during developmet of the genetically obese rat (fafa). Metabolism 27.1955-1965.
  • 8. Harris, R. B., Hervey, E., Hervey, G. R., Tobin, G. (1987) Body composition of lean and obese Zucker rats in parabiosis. Int. J. Obesity 11. 275-283.
  • 9. Isaksson, O., Schwartz, J., Kostyo, J. L., Reagan, C. R. (1979) Use of antibodies to modify the effect of growth hormone on sugar transport in rat diaphragm muscle. Endocrinology 105. 452-458.
  • 10. Johnson, P.R., Zucker, L. M., Cruce, J. A. F., Hirsch, J. (1971) Cellularity of adipose tissue depots in the genetically obese Zucker rat. J. Lipid Res. 12. 706-714.
  • 11. Lebrazi, H., Loireau, A, Chomard, P., Dumas, P., Autissier, N. (1988) Increased response of isolated epididymal adipocytes from the genetically obese Zucker rat to the action of lipolytic drugs after treatment with triiodothyronine. 1st European Congress on Obesity, Stockholm, Abstract Book, p. 127.
  • 12. Levin, B. E., Triscari, J., Sullivan, A. C. (1983) Studies of origins of abnormal sympathetic function in obese Zucker rats. Am. J. Physiol. 245. E. 87-E 93.
  • 13. Lowry, О. H., Rosenbrough, N. J., Farr, A. L., Randall, R. J. (1951) Protein measurement with Folin phenol reagent. J. Biol. Chem. 193. 265-275.
  • 14. Löffler, G., Feick, P., Hauner, H., Herberg, L. (1983) An adipogenic serum factor in genetically obese rodents. FEBS Lett. 153. 179-182.
  • 15. Martin. R. J., Jeanrenaud, B. (1985) Growth hormone in obesity and diabetes: inapropriate hypothalamic control of secretion. Int. J. Obesity 9. Suppl. 199-104.
  • 16. Morikawa, M., Nixon, T., Green, H. (1982) Growth hormone and the adipose conversion of 3T3 cells. Cell 39. 783-789.
  • 17. Rapport, M. M., Alonzo, N. (1955) Photometric determination of fatty acid ester groups in phospholipids. J. Biol. Chem. 217. 193-197.
  • 18. Smith, P. E. (1930) Hypophysectomy and replacement therapy in the rat. Am. J. Anat. 45. 205.
  • 19. Sypniewska, G., Karlsson, M., Björntorp, P. (1986) Adipogenic activity in human plasma. Effect of feeding state and obesity. Int. J. Obesity 10. 265-276.
  • 20. Sypniewska, G., Xuefan, X., Häger, A, Lindahl, A., Björntorp, P., (1987) Effect of age, obesity and growth hormone on adipogenic activity in human plasma. Int. J. Obesity 11, 263-273.
  • 21. Wise, L. S., Green, H. (1979) Participation of one isozyme of cytosolic glycerophosphate dehydrogenase in the adipose conversion of 3T3 cells. J. Biol. Chem. 245. 273-275.
  • 22. Zucker, L. M., Zucker, T. F. (1961) Fatty a new mutation in the rat. J. Hered. 52. 275-278.
  • 23. Zucker, L. M., Antoniades, H. N. (1972) Insulin and obesity in the Zucker genetically obese rat „Fatty". Endocrinology 90. 1320-1330.
Typ dokumentu
Bibliografia
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Identyfikator YADDA
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