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2013 | 18 | 1 |
Tytuł artykułu

Plasma and cancerous tissue concentrations of Zn, Cu and Mn in patients undergoing surgical treatment for gastrointestinal cancer

Treść / Zawartość
Warianty tytułu
PL
Stężenie Zn, Cu i Mn w osoczu i tkance nowotworowej pacjentów leczonych operacyjnie z powodu nowotworów złośliwych przewodu pokarmowego
Języki publikacji
EN
Abstrakty
EN
Gastrointestinal cancers have a complex and multifactorial etiology and their immediate cause remains to be discovered. Elements such as zinc, copper or manganese, which are important components of antioxidant enzymes, may affect malignant processes. The objective of this study was to determine zinc, copper and manganese concentrations in the blood, cancerous and healthy control tissue of patients operated on for gastrointestinal malignancies as well as to assess the effect of surgical removal of the tumour on the concentration of these elements. The study included 68 patients who underwent surgery for gastrointestinal cancers. Patients were divided into three groups according to tumour location: group I – oesophageal cancer, group II – gastric cancer and group III – colorectal cancer. Study material consisted of venous blood samples obtained from patients before the surgery and on the seventh day after the surgery; tissue samples were taken during the surgery. The study has demonstrated that the malignant disease process causes changes in trace element status both in plasma and in cancerous tissues. Copper concentrations were elevated both in patients’ plasma and in cancerous tissues, while a decrease was observed in zinc and manganese concentrations in comparison with control tissue. The surgery affected levels of these elements to various degrees corresponding to the location of removed tumour.
PL
Słowa kluczowe
Wydawca
-
Rocznik
Tom
18
Numer
1
Opis fizyczny
p.135–144,ref.
Twórcy
autor
  • Chair and Department of Medical Chemistry, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland
autor
  • Chair and Department of Medical Chemistry, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland
  • 2nd Chair and Department of General, Gastrointestinal and Oncological Surgery of the Alimentary Tract Medical, University of Lublin, Lublin, Poland
autor
  • 2nd Chair and Department of General, Gastrointestinal and Oncological Surgery of the Alimentary Tract Medical, University of Lublin, Lublin, Poland
autor
  • 2nd Chair and Department of General, Gastrointestinal and Oncological Surgery of the Alimentary Tract Medical, University of Lublin, Lublin, Poland
Bibliografia
Uwagi
PL
Rekord w opracowaniu
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-850ac6d0-5bfb-437f-9688-65429b2d7c26
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