Maternal high fat diet provokes depressive-like behavior in offspring rats and vulnerability to cocaine addiction

• Autorzy: Gawlinski D. , Frankowska M. , Kluska K. , Filip M.
• Języki publikacji: EN

Abstrakty

EN

INTRODUCTION: The epidemiological and animal studies underline that composition of maternal diet (e.g., high fat diet, HFD) is associated with an increased susceptibility to several health problems in the adult offspring, including risk of a cluster of behavioral disorders such as depression. AIM(S): The aim of this study was to investigate the effect of maternal HFD on the offspring phenotype assessed in locomotor activity study, forced swim test (FST) and cocaine self-administration. METHOD(S): Wistar rat dams were maintained ad libitum either on a special HFD (35% crude fat) or standard rodent chow during gestation and lactation (21 days). At postnatal day (PND) 27, the male and female litters were separated from their mother and were switched to a standard diet. Locomotor activity was recorded for 120 min at PND 28 and 63. At PND 34 the FST was performed. Moreover, at PND 63 male rats were introduced into two different cocaine self-administration protocols: 1) stable cocaine dose (0.5 mg/kg/inf.) with increasing schedule of reinforcement fixed ratio (FR) 1 to 5 or 2) increasing cocaine doses (0.25–1 mg/kg/inf.) and stable FR1. Following 10 extinction days, male rats were tested for the response reinstatement of drug-seeking behavior induced by cocaine-priming dose (10 mg/kg, i.p.) and cue (tone+light). RESULTS: HFD group exhibited depressive-like phenotype, characterized by increased immobility time and decreased climbing in both tested time points what was not affected by the changes in basal locomotor activity. The HFD rats displayed an attenuation of the cocaine-associated lever presses and cocaine intake during the acquisition/maintenance of cocaine self-administration and lower response to relapse behavior evoked by cocaine priming or the drug-associated conditioned stimulus. CONCLUSIONS: Our data suggest the influence of maternal HFD on the offspring’s behavior, however underlying molecular mechanism requires further investigations. FINANCIAL SUPPORT: Supported by research grant UMO-2016/21/B/N24/00203 from the NCN (Poland).

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2017
• Tom: 77
• Numer: Suppl.1
• Opis fizyczny: p.118

Twórcy

autor

Gawlinski D.

• Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Cracow,Poland

autor

Frankowska M.

• Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Cracow,Poland

autor

Kluska K.

• Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Cracow,Poland

autor

Filip M.

• Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Cracow,Poland