Analiza porównawcza wpływu dwóch postaci kwasu kwasu amino-3-fosfonopropionowego (AP3) na stężenie kortyzolu w eksperymentalnym stresie jelitowym u owcy

• Autorzy: Kania B.F. , Wronska D.

Warianty tytułu

EN

Comparative analysis of the influence of two forms of 2-Amino-3-phosphonopropionic acid (AP3) on plasma cortisol concentration changes in experimental colonal stress of sheep

• Języki publikacji: PL

Abstrakty

EN

The aim of this study was a comparative analysis of five minute episodes of mechanical colonal descending distension (CD) of different degrees, which were provoked by the insertion of a balloon filled with 150 and/or 200 ml of water (CD150 and/or CD200), and plasma cortisol concentration changes as a consequences of the hypothalamo-pituitary-cortico-adrenal axis (HPA) stimulation and nociceptive/stressoric effects. Furthermore, noting the comparative influence of premedication by metabotropic glutamate receptor antagonists via L-isomer and DL-AP3 racemate i.c.v. one min infusion in three different doses (0.2, 0.4 or 0.8 and 4.0, 8.0 or 12.0 mg in toto, respectively) on the plasma cortisol concentration changes, during 120 min of experimentation. The experiment was carried out in four series using 12 female sheep, Polish Merinos, in the anoestrus period (May–June). In the first series (six animals as a control group) the animals had a 200 μl 0.9% NaCl i.c.v. infusion. In the second series they (six animals) had a five min episode of CD by insertion of a balloon filled with 150 and/ or 200 ml of water (CD150 or CD200). In the third series of the experiment six animals had an i.c.v. DL-AP3 or L-AP3 infusion in three different doses (4.0, 8.0 or 12.0 and 0.2, 0.4 or 0.8 mg in toto, respectively), and in the fourth series, ten minutes before CD200, every week. Colon descending distension episodes lasting five minutes provoke a very repetitive, statistically significant increase of plasma cortisol concentration, a critical indicator of the stressoric effect as a consequence of HPA axis stimulation. Undoubtedly DL-AP3 racemate and L-isomer AP3, as metabotropic nonspecific glutamate receptor type-1 antagonists, attenuated this elevation of cortisol, and can be an alternative drug in colonal pain caused by wall distention in sheep.

Słowa kluczowe

PL

fizjologia zwierzat; owce; stres jelitowy; kwas amino-3-fosfonopropionowy; L-AP3; DL-AP3; bol jelitowy; badania krwi; kortyzol; stezenie kortyzolu

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2014
• Tom: 70
• Numer: 08
• Opis fizyczny: s.497-501,rys.,tab.,bibliogr.

Twórcy

autor

Kania B.F.

• Katedra Biotechnologii Zwierzat, Uniwersyteckie Centrum Medycyny Weterynaryjnej Uniwersytet Jagielloński-Uniwersytet Rolniczy w Krakowie, Al.Mickiewicza 24/28, 30-059 Kraków

autor

Wronska D.

• Katedra Fizjologii i Endokrynologii Zwierząt, Wydział Biologii i Hodowli Zwierząt, Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Al.Mickiewicza 24/28, 30-059 Kraków

Bibliografia

• 1. Dolan S., Nolan A. M.: Blockade of metabotropic glutamate receptor 5 activation inhibits mechanical hypersensitivity following abdominal surgery. Eur. Pain 2007, 11, 644-651.
• 2. Fisher K., Fundytus M. E., Cahil C. M., Coderre T. J.: Intrathecal administration of mGluR compound, (S)-4CPG, attenuates hyperalgesia and allodynia associated with sciatic nerve constriction injury in rats. Pain 1998, 77, 59-66.
• 3. Fundytus M. E., Yashpal K., Chabot J. G., Osborne M. G., Lefebre C. D., Dray A., Henry J. L., Coderre T. J.: Knockdown of spinal metabotropic glutamate receptor 1 (mGluR1) alleviates pain and restores opioid efficacy after nerve injury in rats. Br. J. Pharmacol. 2001, 132, 354-367.
• 4. Kania B. F., Brytan M., Tomaszewska D.: Centrally administered verapamil prevents the autonomic reaction to visceral pain in sheep. Res. Vet. Sci. 2009b, 86, 121-128.
• 5. Kania B. F., Kania K., Romanowicz K., Tomaszewska D., Ŝutiak V., Wrońska-Fortuna D.: Centrally administered PD 140.548 N-mmethyl-D-glukamine prevents the autonomic responses to duodenal pain in sheep. Res. Vet. Sci. 2006, 81, 109-118.
• 6. Kania B. F., Kowalczyk M., Brytan M., Tomaszewska D., Przekop F.: The inhibition of experimentally induced visceral hyperalgesia by nifedypine – a voltage gated Ca2+ channels blocker in sheep. Res. Vet. Sci. 2009a, 86, 285-292.
• 7. Kania B. F., Ŝutiak V.: Influence of centrally administered Diltiazem on behavioural responses, clinical symptoms, reticulo-ruminal contractions and plasma catecholamine level after experimentally induced duodenal distension in sheep. Res. Vet. Sci. 2011, 90, 291-297.
• 8. Kania B. F., Wrońska D.: Supraspinal basis of analgesic and clinical effects of the metabotropic glutamate mGluR1 antagonist during colonic distension in sheep. Small Rum. Res. 2014, 117, 84-93.
• 9. Landgraf R., Neuman I. D.: Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication. Front Neuroendocrinol. 2004, 25, 150-176.
• 10. Lee K. S., Kim J., Yoon Y. W., Lee M. G., Hong S. K., Han H. C.: The peripheral role of group I metabotropic glutamate receptors on nociceptive behaviors in rats with knee joint inflammation. Neurosci. Lett. 2007, 416, 123-127.
• 11. Wrońska-Fortuna D., Błachuta M., Hajduk M.: The effect of ACTH on in vitro OXY release from sheep adrenal gland. Proc. 21th Mol. and Physiol. Aspects of Regulatory Processes of the Organism. Cracow 2012, Proc. pp. 409-410.