Influence of chlorpyrifos on the profile of subpopulations of immunoactive cells and their phagocytic activity in an experimental in vivo model

• Autorzy: Noworyta-Glowacka J. , Bankowski R. , Siennicka J. , Wiadrowska B. , Ludwicki J. K.
• Języki publikacji: EN

Abstrakty

EN

Many environmental factors, including pesticides, cause immunological system disorders by inducing changes in humoral and cellular response. They may stimulate or trigger immunological autoaggression, hypersensitivity and allergy, as well as lead to immunosuppression, thus increasing the incidence of infectious diseases and cancers. Such activity is also attributed to organophosphorus compounds used in agriculture as insecticides, and commonly in households as biocides. The aim of the study was to define possible mechanisms of the immunotoxic activity of the chlorpyrifos (an organophosphorus compound) on experimental animals following their exposure to the compound via the oral route. The present study attempts to define the influence of chlorpyrifos on the profile of subpopulations of immunoactive cells: B, T, CD4+, CD8+, and NK, and on their phagocytic activity in an experimental in vivo model. For this purpose, the Wistar rats, were exposed orally to increasing doses of chlorpyrifos: 0.1 LD50, 0.15 LD50, 0.2 LD50, 0.3 LD50 and 0.4 LD50 for 28 days. In the study animals, we failed to demonstrate a statistically significant decrease in the phagocytic activity of the granulocyte.

• Wydawca: -
• Czasopismo: Annals of Agricultural and Environmental Medicine
• Rocznik: 2012
• Tom: 19
• Numer: 3
• Opis fizyczny: p.483-486,fig.,ref.

Twórcy

autor

Noworyta-Glowacka J.

• Department of Toxicology and Risk Assessment, National Institute of Public Health – National Institute of Hygiene, Warsaw, Poland

autor

Bankowski R.

• Department of Toxicology and Risk Assessment, National Institute of Public Health – National Institute of Hygiene, Warsaw, Poland

autor

Siennicka J.

• Department of Virology, National Institute of Public Health – National Institute of Hygiene, Warsaw, Poland

autor

Wiadrowska B.

• Department of Toxicology and Risk Assessment, National Institute of Public Health – National Institute of Hygiene, Warsaw, Poland

autor

Ludwicki J. K.

• Department of Toxicology and Risk Assessment, National Institute of Public Health – National Institute of Hygiene, Warsaw, Poland

Bibliografia

• 1. Casale GP, Cohen SD, Di Capua RA. The effects of organophosphateinduced cholinergic stimulation on the antibody response to sheeperythrocytes in inbred mice. Toxicol Appl Pharmacol. 1983; 68: 198-205.
• 2. Johnson V J, Rosenberg AM, Lee K, Blakley BR. Increased T-lymhocyte dependent antibody production in female SJL/J mice following exposureto commercial grade malathion. Toxicology 2002; 170: 119-129.
• 3. Zabrodskii PF, Germanchuk VG. Role of activation of sympathoadrenal system in the realization of immune reactions during acute poisoningwith organophosphorus compounds. Bull Exp Biol Med. 2001; 132:966-968.
• 4. Oostingh GJ, Wichmann G, Schmittner M, Lehmann I, Duschl A: The cytotoxic effects of the organophosphates chlorpyrifos and diazinon differ from their immunomodulating effects. J Immunotoxicol. 2009; 2: 136-45.
• 5. Pruett SB, Chambers JE. Effects of paraoxon, p-nitrophenol, phenyl saligenin cyclic phosphate, and phenol on the rat interleukin 2 system.Toxicol Lett. 1988; 40: 11-20.
• 6. Li Q. New mechanism of Organophosphorus pesticide-induced immunotoxicity. J Nippon Med School. 2007; 74(2): 92-104.
• 7. Thrasher JD, Heuser G, Broughton A. Immunological abnormalities in humans chronically exposed to chlorpyrifos. Arch Environ Health.2002; 57: 181-187.
• 8. Li Q, Nakadai A, Ishizaki M. Dimethyl 2,2 – dichlorovinyl phosphate (DDVP) markedly decreases the expression of perforin, granzyme Aand granulysin in human NK-92CI cell line. Toxicology 2005; 312:107-116.
• 9. Casale GP, Vennerstrom JL, Bavari S, Wang TL. Inhibition of interleukiny 2 driven proliferation of mouse CTLL2 cells, by selected carbamate and organophosphate insecticides and congeners of carbaryl.Immunopharmacol Immunotoxicol. 1993; 15: 199-215.
• 10. Wong S, Fournier M, Coderre D, Banska W, Krzystyniak K. Environmental immunotoxicology. In: Peakall D (Eds.). AnimalBiomarkers as Pollution Indicators. Chapman and Hall, London. 1992,p. 167-189.
• 11. Voccia I, Blakley B, Brousseau P, Fournier M. Immunotoxicity of pesticides: a review. Toxicol Indust Health. 1999; 15: 119-132.
• 12. Lutz W, Pałczyński C. Immunotoksykologia. Immunosupresja. Immunotoksyny wywołujące immunosupresję układu odpornościowego. Instytut Medycyny Pracy im. Prof. J. Nofera. 80- 81, Łódź 2005.
• 13. Węgorek P, Mrówczyński M, Zamojska J. Resistance of pollen beetle (meligethes aeneus f.) to selected active substances of insecticides in Poland. J Plant Protect Res. 2002; 49(1): 119-127.
• 14. Bleecker JD, Neucker KVD, Willems J. The intermediate syndrome in organophosphate poisoning: Presentation of a case and review of theliterature. Clin Toxicol. 1992; 30: 321-329.
• 15. Blakley BR, Yole MJ, Brousseau P, Boermans H, Fournier M. Effect of chlorpyrifos on immune function in rats. Toxicol. 1999; 41: 140-144.
• 16. Czeizel AE. Human germinal mutagenic effects in relation to international and accidental exposure to toxic agents. Environ HealthProspect. 1996; 104 (Suppl. 3): 615-617.
• 17. Cossarini-Dunier M, Siwicki AK, Demael A. Effect of organophosphorus insecticides: Trichlorfon and dichlorvos on immune response of carp(Cyprinus carpio). III. In vitro effect on humoral response. EcotoxicolEnviron Saf 1991; 22: 79-87.
• 18. Cossarini-Dunier M, Demael A, Siwicki AK. In vivo effect of an organophosphorus insecticide: Trichlorfon on immune response of carp (Cyprinus carpio). I. Effect of contamination on antibody production with residue levels in organs. Ecotoxicol Environ Saf. 1990; 19: 93-99.

Uwagi

rekord w opracowaniu