Switching handedness: fMRI study of hand motor control in right-handers and converted left-handers

• Autorzy: Grabowska A. , Gut M. , Binder M. , Forsberg L. , Rymarczyk K. , Urbanik A.
• Języki publikacji: EN

Abstrakty

EN

The purpose of this study was to investigate the differences in the brain organization of motor control in left- and right¬handers and to study whether early left-to-right handwriting switch changes the cortical representation of finger movements in the left and right hemispheres. Echo-planar MR imaging was performed in 52 subjects: consistent right-handers (RH), consistent left-handers (LH), and subjects who had been forced at an early age to switch their left-hand preferences toward the right side. The scanning was performed during simple (flexion/extension of the index finger) and complex (successive finger-thumb opposition) tasks. Subjects performed the tasks using both the preferred and non-preferred hand. In right¬handers, there was a general predominance of left-hemisphere activation relative to right hemisphere activation. In left¬handers this pattern was reversed. The switched subjects showed no such volumetric asymmetry. Increasing levels of complexity of motor activity resulted in an increase in the volume of consistently activated areas and the involvement of the ipsilateral in addition to contralateral activations. In both right- and left-handers, movements of the preferred hand activated mainly the contralateral hemisphere, whereas movements of the non-preferred hand resulted in a more balanced pattern of activation in the two hemispheres, indicating greater involvement of the ipsilateral activations. Overall, this study shows that in both left- and right-handed subjects, the preferred hand is controlled mainly by the hemisphere contralateral to that hand, whereas the non-preferred hand is controlled by both hemispheres. The switched individuals share features of both left¬handers and right-handers regarding their motor control architectures.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2012
• Tom: 72
• Numer: 4
• Opis fizyczny: p.439-451,fig.,ref.

Twórcy

autor

Grabowska A.

• Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland
• Department of Psychology, Warsaw School of Social Sciences and Humanites, Warsaw, Poland

autor

Gut M.

• Department of Cognitive Psychology, University of Finance and Management, Warsaw, Poland

autor

Binder M.

• Institute of Psychology, Jagiellonian University, Krakow, Poland

autor

Forsberg L.

• Karolinska Institute, Stockholm, Sweden

autor

Rymarczyk K.

• Institute of Psychology, Jagiellonian University, Krakow, Poland

autor

Urbanik A.

• Collegium Medicum, Jagiellonian University, Krakow, Poland

Bibliografia

• Allison JD, Meador KJ, Loring DW, Figueroa RE, Wright JC (2000) Functional MRI cerebral activation and deacti¬vation during finger movement. Neurology 54: 135-142.
• Amunts K, Schlaug G, Schleicher A, Steinmetz H, Dabringhaus A, Roland PE, Zilles K (1996) Asymmetry in the human motor cortex and handedness. Neuroimage 4: 216-222.
• Amunts K, Jancke L, Mohlberg H, Steinmetz H, Zilles K (2000) Interhemispheric asymmetry of the human motor cortex related to handedness and gender. Neuropsychologia 38: 304-312.
• Annett M (2002) Handedness and Brain Asymmetry. The Right Shift Theory. Psychology Press, Taylor and Francis Inc., USA and Canada.
• Baraldi P, Porro CA, Serafini M, Pagnoni G, Murari C, Corazza R, Nichelli P (1999) Bilateral representation of sequential finger movements in human cortical areas. Neurosci Lett 269: 95-98.
• Carter-Saltzman L (1980) Biological and sociocultural effects on handedness: comparison between biological and adoptive families. Science 209: 1263-1265.
• Dassonville P, Zhu X-H, Ugurbil K, Kim S-G, Ashe J (1997) Functional activation in motor cortex reflects the direc¬tion and the degree of handedness. Proc Natl Acad Sci U S A 94: 14015-14018.
• Draganski B, Gaser C, Busch V, Schuierer G, Bogdahn U, May A (2004) Neuroplasticity: changes in grey matter induced by training. Nature 427: 311-312.
• Geyer S, Ledberg A, Schleicher A, Kinomura S, Schormann T, Burgel U, Klinberg T, Larsson J, Zilles K, Roland PE (1996) Two different areas within the primary motor cor¬tex of man. Nature 29: 805-807.
• Geyer S, Schleicher A, Zilles K (1999) Areas 3a, 3b and 1 of human primary somatosensory cortex. Neuroimage 10: 63-83.
• Grabowska A, Herman A, Nowicka A, Szatkowska I, Szeląg E (1994) Individual differences in the functional asym¬metry of the human brain. Acta Neurobiol Exp (Wars) 54: 155-162.
• Gut M, Urbanik A, Forsberg L, Binder M, Rymarczyk K, Sobiecka B, Kozub J, Grabowska A (2007) Brain corre¬lates of right-handedness. Acta Neurobiol Exp (Wars) 67: 43-51.
• Haaland KY, Harrington DL (1996) Hemispheric asymmetry of movement. Curr Opin Neurobiol 6: 796-800.
• Harris LJ (1990) Cultural influences on handedness: Historical and contemporary theory and evidence. In: Left-Handedness: Behavioral Implications and Anomalies (Coren S, Ed.) North-Holland, Elsevier Science Publishers B.V, Amsterdam, NL. p. 195-258.
• Heilman KM (2000) Limb apraxias: higher-order disorders of sensorimotor integration. Brain 123: 860-879.
• Hervé PY, Mazoyer B, Crivello F, Perchey G, Tzourio- Mazoyer N (2005) Finger tapping, handedness and grey matter amount in the Rolando's genu area. Neuroimage 25: 1133-1145.
• Hlustik P, Solodkin A, Gullapalli RP, Noll DC, Small SL (2002) Functional lateralization of the human premotor cortex during sequential movements. Brain Cogn 49: 54-62.
• Kawashima R, Inoue K, Sato K, Fukuda H (1997) Functional asymmetry of cortical motor control in left-handed sub¬jects. Neuroreport 8: 1729-1732.
• Kim S-G, Ashe J, Hendrich K, Ellermann JM, Merkle H, Ugurbil K, Georgopoulos A P (1993) Functional mag¬netic resonance imaging of motor cortex: hemispheric asymmetry and handedness. Science 261: 615-617.
• Klöppel S, Vongerichten A, van Eimeren T, Frackowiak RS, Siebner HR (2007) Can left-handedness be switched? Insights from an early switch of handwriting. J Neurosci 27: 7847-7853.
• Klöppel S, Mangin JF, Vongerichten A, Frackowiak RS, Siebner HR (2010) Nurture versus nature: long-term impact of forced right-handedness on structure of peri¬central cortex and basal ganglia. J Neurosci 30: 3271¬3275.
• Kobayashi M, Siobhan H, Schlaug G, Pascual-Leone A (2003) Ipsilateral motor cortex activation on functional magnetic resonance imaging during unilateral hand move¬ments is related to interhemispheric interactions. Neuroimage 20: 2259-2270.
• Kuypers HGJM (1981) Anatomy of the descending pathway. In: Handbook of Physiology: The Nervous System (Brockhart JM, Mountcastle VB, Eds). American Physiological Society, Bethesda, MD. p. 597-666.
• Nathan PW, Smith MC, Deacon P (1990) The corticospinal tracts in man. Course and location of fibres at different segmental levels. Brain 113: 303-324.
• Newton JM, Sunderland A, Gowland PA (2005) fMRI signal decreases in ipsilateral primary motor cortex during uni¬lateral hand movements are related to duration and side of movement. Neuroimage 24: 1080-1087.
• Nirkko AC, Ozdoba C, Redmond SM, Burki M, Schroth G, Hess CW, Wiesendanger M (2001) Different ipsilateral representations for distal and proximal movements in the sensorimotor cortex: activation and deactivation patterns. Neuroimage 13: 825-835.
• Oldfield RC (1971) The assessment and analysis of handed¬ness: the Edinburgh Inventory. Neuropsychologia 9: 97-113.
• Pascual-Leone A, Amedi A, Fregni F, Merabet LB (2005) The plastic human brain cortex. Annu Rev Neurosci 28: 377-401.
• Porac C, Friesen IC (2000) Hand preference side and its relation to hand preference switch history among old and oldest-old adults. Dev Neuropsychol 17: 225-239.
• Rinehart JK, Singleton RD, Adair JC, Sadek JR, Haaland KY (2009) Arm use after left or right hemiparesis is influ¬enced by hand preference. Stroke 40: 545-550.
• Rocca MA, Falini A, Comi G, Scotti G, Filippi M (2008) The mirror-neuron system and handedness: a "right" world? Hum Brain Mapp 29: 1243-1254.
• Roland PE, Zilles K (1994) Brain atlases - a new research tool. Trends Neurosci 17: 458-467.
• Schleicher A, Amunts K, Geyer S, Morosan P, Zilles K (1999) Observer-independent method for microstructural parcellation of cerebral cortex: A quantitative approach to cytoarchitectonics. Neuroimage 9: 165-177.
• Searleman A, Porac C (2001) Lateral preference patterns as possible correlates of successfully switched left hand writing: data and a theory. Laterality 6: 303-314.
• Siebner HR, Limmer C, Peinemann A, Drzezga A, Bloem BR, Schwaiger M, Conrad B (2002) Long-term conse¬quences of switching handedness: a positron emission tomography study on handwriting in „converted" left¬handers. J Neurosci 22: 2816-2825.
• Singh LN, Higano S, Takahashi S, Kurihara N, Furuta S, Tamura H, Shimanuki Y, Mugikura S, Fujii T, Yamadori A, Sakamoto M, Yamada S (1998) Comparison of ipsi¬lateral activation between right and left handers: a functional MR imaging study. Neuroreport 9: 1861¬1866.
• Smitch SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Niazy RK, Saunders J, Vickers J, Zhang Y, De Stefano N, Brady JM, Matthews PM (2004)
• Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23 Suppl. 1: S208-S219.
• Smith JF, Chen K, Johnson S, Morrone-Strupinsky J, Reiman EM, Nelson A, Moeller JR, Alexander GE (2006) Network analysis of single-subject fMRI during a finger opposition task. Neuroimage 32: 325-332.
• Solodkin A, Hlustik P, Noll DC, Small SL (2001) Lateralization of motor circuits and handedness during finger movements. Eur J Neurol 8: 425-434.
• Undeman C, Lindeberg T (2003) Fully automatic segmenta¬tion of MRI brain images using probabilistic anisotropic diffusion and multi-scale watersheds. Scale Space Methods in Computer Vision 2695: 641-656.
• Verstynen T, Diedrichsen J, Albert N, Aparicio P, Ivry RB (2005) Ipsilateral motor cortex activity during unimanual hand movements relates to task complexity. J Neurophysiol 93: 1209-1222.
• Volkman J, Schnitzler A, Witte OW, Freund H-J (1998) Handedness and asymmetry of hand representation in human motor cortex. J Neurophysiol 79: 2149-2154.
• White LE, Lucas G, Richards A, Purves D (1994) Cerebral asymmetry and handedness. Nature 368: 197-198.
• Wu X, Chen K, Liu Y, Long Z, Wen X, Jin Z, Yao L (2008) Ipsilateral brain deactivation specific to the nondominant hand during simple finger movements. Neuroreport 19: 483-486.

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