Ribonucleoparticles in dendritic arbor development

• Autorzy: Jaworski J.
• Języki publikacji: EN

Abstrakty

EN

Dendrites are the main site of information input into neurons. Development of a dendritic tree is multistep and very complex process, which is tightly regulated by combination of extracellular cues and execution of intrinsic genetic program. An important cellular process for proper dendritic arbor development is local production of key structural proteins in response to neuronal activity and trophic factors. This so called local translation requires transport and storage of translationally dormant mRNAs along dendrites in form of ribonucleoparticles. The data form overexpression and knockdown experiments will be presented, supporting important role of selected components of ribonucleoparticles, e.g., ZBP1 and Staufen 1 in proper development of dendritic arbors of hippocampal neurons. Using ZBP1 and its target, b-actin mRNA, as examples I will show how, on a molecular level, ZBP1 contributes to dendritic growth. Finally, evidence for a positive role of protein kinases such as Src and mTOR in regulation of ZBP1-dependnet dendritic growth will be presented. This work is supported by ICGEB grant no. CRP/POL11-02.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.21-22

Twórcy

autor

Jaworski J.

• International Institute of Molecular and Cell Biology, Warsaw, Poland