Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2018 | 78 | 4 |
Tytuł artykułu

Detrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride‑induced experimental Alzheimer’s disease

Warianty tytułu
Języki publikacji
Polyphenols and omega‑3 fatty acids are thought to have beneficial effects in Alzheimer’s disease, the most common cause of dementia. Seeds of chia (Salvia hispanica L.) are highly rich in these nutrients, and thus, the present study investigated the effects of chia seeds on behavior and cognition in an aluminum‑induced Alzheimer’s disease model in rats. Experimental animals received chia supplementation either during the generation of the model (i.e., pretreatment) or after the model was established (i.e., treatment). A battery of behavioral and cognitive tests were performed, including open‑field, elevated plus maze, Porsolt’s forced swim, and Morris’ water maze, to evaluate anxiety‑ and depression‑like behaviors, and learning and memory. Results showed that chia supplementation was ineffective against Alzheimer’s‑related anxiety, whereas depression‑like behaviors were attenuated with both pretreatment and treatment. There was no improvement in learning and memory with chia treatment. Rather, cognitive performance in chia‑pretreated animals was remarkably worse as compared to their non‑treated disease‑induced counterparts. Hippocampal concentrations of amyloid‑β42, amyloid precursor protein, and total tau protein were similarly increased in all disease‑induced animals (despite chia supplementation), as compared to the controls. Based on these findings, chia supplementation during the progression of Alzheimer’s disease may exacerbate the disease. Although the results presented here emerge from an experimental/ preclinical study, we suggest cautious and careful use of chia, especially in early‑stage Alzheimer’s patients, until future research in different experimental settings is conducted.
Słowa kluczowe
Opis fizyczny
  • Department of Physiology, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey
  • Department of Physiology, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey
  • Department of Molecular Biochemistry and Genetics, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey
  • Department of Physiology, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey
  • Department of Physiology, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey
  • Department of Physiology, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey
  • Alzheimer’s Association (2018) 2018 Alzheimer’s disease facts and figures. Alzheimer’s Dement 14: 367–429.
  • Barberger‑Gateau P, Raffaitin C, Letenneur L, Berr C, Tzourio C, Dartigues JF, Alpérovitch A (2007) Dietary patterns and risk of dementia: the Three‑City cohort study. Neurology 69: 1921–1930.
  • Bhullar KS, Rupasinghe HPV (2013) Polyphenols: multipotent therapeu‑ tic agents in neurodegenerative diseases. Oxid Med Cell Longev 2013: 891748.
  • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein‑dye binding. Anal Biochem 72: 248–254.
  • Campbell A (2002) The potential role of aluminium in Alzheimer’s disease. Nephrol Dial Transplant 17: 17–20.
  • Canhada S, Castro K, Perry IS, Luft VC (2017) Omega‑3 fatty acids’ supple‑ mentation in Alzheimer’s disease: A systematic review. Nutr Neurosci 21: 529–538.
  • Cannata Andia JB (1996) Aluminium toxicity: its relationship with bone and iron metabolism. Nephrol Dial Transplant 11: 69–73.
  • Castorina A, Tiralongo A, Giunta S, Carnazza ML, Scapagnini G, D’Agata V (2010) Early effects of aluminum chloride on beta‑secretase mRNA ex‑ pression in a neuronal model of beta‑amyloid toxicity. Cell Biol Toxicol 26: 367–377.
  • Chiroma SM, Mohd Moklas MA, Mat Taib CN, Baharuldin MTH, Amon Z (2018) d‑galactose and aluminium chloride induced rat model with cog‑ nitive impairments. Biomed Pharmacother 103: 1602–1608.
  • Decker EA (1997) Phenolics: prooxidants or antioxidants? Nutr Rev 55: 396–398.
  • Even C, Weintraub D (2010) Case for and against specificity of depression in Alzheimer’s disease. Psychiatry Clin Neurosci 64: 358–366.
  • Exley C (2004) The pro‑oxidant activity of aluminum. Free Radic Biol Med 36: 380–387.
  • Exley C (2013) Human exposure to aluminium. Environ Sci Process Impacts 15: 1807–1816. Friard O, Gamba M (2016) BORIS: a free, versatile open-source event-log‑ ging software for video/audio coding and live observations. Methods Ecol Evol 7: 1325–1330.
  • Fu Z, Sinclair AJ (2000) Increased α‑linolenic acid intake increases tissue α‑linolenic acid content and apparent oxidation with little effect on tis‑ sue docosahexaenoic acid in the guinea pig. Lipids 35: 395–400.
  • Gupta VB, Anitha S, Hegde ML, Zecca L, Garruto RM, Ravid R, Shankar SK, Stein R, Shanmugavelu P, Jagannatha Rao KS (2005) Aluminium in Alzheimer’s disease: are we still at a crossroad? Cell Mol Life Sci 62: 143–158.
  • Hooijmans CR, Pasker‑de Jong PCM, de Vries RBM, Ritskes‑Hoitinga  M (2012) The effects of long‑term omega‑3 fatty acid supplementation on cognition and Alzheimer’s pathology in animal models of Alzheimer’s disease: a  systematic review and meta‑analysis. J Alzheimers Dis 28: 191–209.
  • Huang TL, Zandi PP, Tucker KL, Fitzpatrick AL, Kuller LH, Fried LP, Burke GL, Carlson MC (2005) Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4. Neurology 65: 1409–1414.
  • Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM (1997) Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol 42: 776–782.
  • Kametani F, Hasegawa  M (2018) Reconsideration of amyloid hypothesis and tau hypothesis in Alzheimer’s disease. Front Neurosci 12: 25.
  • Kelsey NA, Wilkins HM, Linseman DA (2010) Nutraceutical antioxidants as novel neuroprotective agents. Molecules 15: 7792–7814.
  • Lee HB, Lyketsos CG (2003) Depression in Alzheimer’s disease: heteroge‑ neity and related issues. Biol Psychiatry 54: 353–362.
  • Margină D, Ilie M, Grădinaru D, Androutsopoulos VP, Kouretas D, Tsatsakis AM (2015) Natural products‑friends or foes? Toxicol Lett 236: 154–167.
  • Maric NP, Adzic M (2013) Pharmacological modulation of HPA axis in de‑ pression – new avenues for potential therapeutic benefits. Psychiatr Danub 25: 299–305.
  • Muñoz LA, Cobos A, Diaz O, Aguilera JM (2013) Chia seed (Salvia hispanica): an ancient grain and a new functional food. Food Rev Int 29: 394–408.
  • Nabavi SF, Tenore GC, Daglia M, Tundis R, Loizzo MR, Nabavi SM (2015) The cellular protective effects of rosmarinic acid: from bench to bed‑ side. Curr Neurovasc Res 12: 98–105.
  • Nemeth M, Millesi E, Wagner K‑H, Wallner B (2014) Effects of diets high in unsaturated fatty acids on socially induced stress responses in Guinea pigs. PloS One 9: e116292.
  • Nemeth M, Millesi E, Wagner K‑H, Wallner B (2015) Sex‑specific effects of diets high in unsaturated fatty acids on spatial learning and memory in Guinea Pigs. PloS One 10: e0140485.
  • Nihonmatsu‑Kikuchi N, Hayashi Y, Yu XJ, Tatebayashi Y (2013) Depression and Alzheimer’s disease: novel postmortem brain studies reveal a pos‑ sible common mechanism. J Alzheimers Dis 37: 611–621.
  • Novais F, Starkstein S (2015) Phenomenology of depression in Alzheimer’s disease. J Alzheimers Dis 47: 845–855.
  • Onneken P (2018) Salvia hispanica L (Chia Seeds) as brain superfood: how seeds increase intelligence. J Nutr Food Sci 8: 684.
  • Osborn HT, Akoh CC (2003) Effects of natural antioxidants on iron‑cata‑ lyzed lipid oxidation of structured lipid‑based emulsions. J Am Oil Chem Soc 80: 847–852.
  • Pellegrini  M, Lucas‑Gonzalez R, Sayas‑Barberá E, Fernández‑López J, Pérez‑Álvarez JA, Viuda‑Martos  M (2018) Bioaccessibility of phenolic compounds and antioxidant capacity of chia (Salvia hispanica L.) seeds. Plant Foods Hum Nutr 73: 47–53.
  • Rodrigues R, Petersen RB, Perry G (2014) Parallels between major depres‑ sive disorder and Alzheimer’s disease: role of oxidative stress and ge‑ netic vulnerability. Cell Mol Neurobiol 34: 925–949.
  • Rui Y, Lv M, Chang J, Xu J, Qin L, Wan Z (2018) Chia seed does not improve cognitive impairment in SAMP8 mice fed with high fat diet. Nutrients 10: 1084.
  • Ruipérez F, Mujika JI, Ugalde JM, Exley C, Lopez X (2012) Pro‑oxidant activity of aluminum: promoting the Fenton reaction by reducing Fe(III) to Fe(II). J Inorg Biochem 117: 118–123.
  • Sargi SC, Silva BC, Santos HMC, Montanher PF, Boeing JS, Santos Júnior OO, Souza NE, Visentainer JV (2013) Antioxidant capacity and chemical com‑ position in seeds rich in omega‑3: chia, flax, and perilla. Food Sci Technol 33: 541–548.
  • Shaw CA, Tomljenovic L (2013) Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoim‑ munity. Immunol Res 56: 304–316.
  • Ulbricht C, Chao  W, Nummy K, Rusie E, Tanguay‑Colucci S, Iannuzzi C, Plammoottil J, Varghese  M, Weissner  W (2009) Chia (Salvia hispanica): A systematic review by the natural standard research collaboration. Rev Recent Clin Trials 4: 168–174.
  • van den Driessche JJ, Plat J, Mensink RP (2018) Effects of superfoods on risk factors of metabolic syndrome: a systematic review of human interven‑ tion trials. Food Funct 9: 1944–1966.
  • Virk SA, Eslick GD (2015) Aluminum levels in brain, serum, and cerebrospi‑ nal fluid are higher in Alzheimer’s disease cases than in controls: a se‑ ries of meta‑analyses. J Alzheimers Dis 47: 629–638.
  • Walton JR (2006) Aluminum in hippocampal neurons from humans with Alzheimer’s disease. Neurotoxicology 27: 385–394.
  • Walton JR (2007) An aluminum‑based rat model for Alzheimer’s disease exhibits oxidative damage, inhibition of PP2A activity, hyperphosphor‑ ylated tau, and granulovacuolar degeneration. J Inorg Biochem 101: 1275–1284.
  • Walton JR (2014) Chronic aluminum intake causes Alzheimer’s disease: ap‑ plying Sir Austin Bradford Hill’s causality criteria. J Alzheimers Dis 40: 765–838.
  • Wang Z, Wei X, Yang J, Suo J, Chen J, Liu X, Zhao X (2016) Chronic exposure to aluminum and risk of Alzheimer’s disease: A meta‑analysis. Neurosci Lett 610: 200–206.
  • Xiao F, Li XG, Zhang XY, Hou JD, Lin LF, Gao Q, Luo HM (2011) Combined administration of D‑galactose and aluminium induces Alzheimer‑like le‑ sions in brain. Neurosci Bull 27: 143–155.
Typ dokumentu
Identyfikator YADDA
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.