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2012 | 15 | 3 |
Tytuł artykułu

Inflammation- and axotomy-induced changes in cocaine- and amphetamine-regulated transcript peptide-like immunoreactive (CART-LI) nervous structures in the porcine descending colon

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Języki publikacji
EN
Abstrakty
EN
This study reports on changes in CART-like immunoreactive (CART-LI) nerve structures in the porcine descending colon during chemically driven inflammation and after axotomy. The distribution pattern of CART-LI nerve structures was studied using doublelabeling immunofluorescence technique in the circular muscle layer, myenteric (MP), outer submucous (OSP) and inner submucous plexuses (ISP) and also in the mucosal layer of the porcine descending colon in physiological conditions as well as under pathological factors. In the control animals, CART-LI perikarya have been shown to constitute 5.11% ± 0.64, 4.03% ± 1.17 and 0.05% ± 0.04 in MP, OSP and ISP, respectively. Changes in CART-immunoreactivity depended on the pathological factor and the part of the enteric nervous system (ENS) studied. Numbers of CART-LI perikarya amounted to 2.77% ± 0.64, 2.60% ± 0.36 and 0.26% ± 0.19 during chemically-induced colitis and 3.04% ± 0.88, 2.46% ± 0.8 and 0.43% ± 0.09 after axotomy in MP, OSP and ISP, respectively. Both studied pathological processes also caused an increase in the number of CART-LI nerve fibers in the circular muscle as well as in the mucosal layer.
Wydawca
-
Rocznik
Tom
15
Numer
3
Opis fizyczny
p.517-524,fig.,ref.
Twórcy
  • Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13/024, 10-718 Olsztyn-Kortowo, Poland
Bibliografia
  • Arciszewski MB, Barabasz S, Skobowiat C, Maksymowicz W, Majewski M (2009) Immunodetection of cocaine- and amphetamine-regulated transcript in the rumen, reticulum, omasum and abomasums of the sheep. Anat Histol Embryol 38: 62-67.
  • Arciszewski MB, Ekblad E (2005) Effects of vasoactive intestinal petide and galanin on survival of cultured porcine myenteric neurons. Regul Pept 125: 185-192.
  • Crowe R, Burnstock G (1989) A histochemical and immunohistochemical study of the autonomic innervation of the lower urinary tract of the female pig. Is the pig a good model for the human bladder and urethra? J Urol 141: 414422.
  • Delvaux M (2004) Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome. Best Pract Res Clin Gastroenterol 18: 747-771.
  • Ekblad E (2006) CART in the enteric nervous system. Peptides 27: 2024-2030.
  • Ekblad E, Eklund M, Sundler F (1999) Neuronal plasticity in intestinal adaptation. In: Kramer HJ, Singer MV (eds) Neurogastroenterology: from Basic to the Clinics. Kluwer Academic Publishers, Dordrecht, Boston, London, pp 33-34.
  • Ekblad E, Kuhar M, Wierup N, Sundler F (2003) Cocaineand amphetamine-regulated transcript: distribution and function in rat gastrointestinal tract. Neurogastroenterol Motil 15: 545-557.
  • Ellis LM, Mawe GM (2003) Distribution and chemical coding of cocaine- and amphetamine-regulated transcript peptide (CART)-immunoreactive neurons in the guinea pig bowel, Cell Tissue Res 312: 265-274.
  • Furness JB (2006) The enteric nervous system. Blackwell Publishing. Gonkowski S, Burliński P, Skobowiat C, Majewski M, Arciszewski MB, Radziszewski P, Całka J (2009a) Distribution of cocaine- and amphetamine-regulated transcript-like immunoreactive (CART-LI) nerve structures in the porcine large intestine. Acta Vet Hung 57: 509-520.
  • Gonkowski S, Burliński P, Skobowiat C, Majewski M, Całka J (2010) Inflammation- and axotomy-induced changes in galanin-like immunoreactive (GAL-LI) nervous structures in the porcine descending colon. Acta Vet Hung 58: 91-103.
  • Gonkowski S, Kamińska B, Burliński P, Kroll A, Całka J (2009b) The influence of drug-resistant ulcerative colitis on the number of cocaine- and amphetamine-regulated transcript peptide-like immunoreactive (CART-LI) mucosal nerve fibres of the descending colon in children. Gastroenterol Rev 4: 147-151.
  • Gunnarsdóttir A, Wierup N, Larsson LT, Kuhar MJ, Ekblad E (2007) CART-peptide immunoreactivity in enteric nerves in patients with Hirschsprung’s disease. Eur J Pediatr Surg 17: 184-189.
  • Hou JK, El-Seraq H, Thirumurthi S (2009) Distribution and manifestations of inflammatory bowel disease in Asians, Hispanics, and African Americans: a systematic review. Am J Gastroenterol 104: 2100-2109.
  • Hunter RG, Philpot K, Vicentic A, Dominguez G, Hubert GW, Kuhar MJ (2004) CART in feeding and obesity. Trends Endocrinol Metab 15: 454-459.
  • Koylu EO, Balkan B, Kuhar MJ, Pogun S (2006) Cocaine and amphetamine regulated transcript (CART) and the stress response. Peptides 27: 1956-1969.
  • Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393: 72-76.
  • Mawdsley JE, Rampton DS (2005) Psychological stress in IBD: new insights into pathogenic and therapeutic implications. Gut 54: 1481-1491.
  • Okumura T, Yamada H, Motomura W, Kohgo Y (2000) Cocaine- and amphetamine-regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corticotrophin-releasing factor system. Endocrinology 141: 2854-2860.
  • Pellissier S, Dantzer C, Canini F, Mathieu N, Bonaz B (2010) Psychological adjustment and autonomic disturbances in inflammatory bowel diseases and irritable bowel syndrome. Psychoneuroendocrinology 35: 653-662.
  • Pidsudko Z, Kaleczyc J, Majewski M, Łakomy M, Scheuermann DW, Timmermans JP (2001) Differences in the distribution and chemical coding between neurons in the inferior mesenteric ganglion supplying the colon and rectum in the pig. Cell Tissue Res 303: 147-158.
  • Pidsudko Z, Kaleczyc J, Wąsowicz K, Sienkiewicz W, Majewski M, Zając W, Łakomy M (2008) Distribution and chemical coding of intramural neurons in the porcine ileum during proliferative enteropathy. J Comp Path 138: 23-31.
  • Risold PY, Bernard-Franchi G, Collard C, Jacquemard C, La Roche A, Griffond B (2006) Ontogenetic expression of CART-peptides in the central nervous system and the periphery: a possible neurotrophic role? Peptides 27: 1938-1941.
  • Spiess J, Villarreal J, Vale W (1981) Isolation and sequence analysis of a somatostatin-like polypeptide from ovine hypothalamus. Biochemistry 20: 1982-1988.
  • Swindle MM (1992) Swine as models in biomedical research. 1st ed., Ames, Iowa, Iowa State University Press. Tebbe JJ, Ortmann E, Schumacher K, Mönnikes H, Kobelt P, Arnold R, Schäfer MK (2004) Cocaine- and amphetamine-regulated transcript stimulates colonic motility via central CRF receptor activation and peripheral cholinergic pathways in fed conscious rats. Neurogastroenterol Motil 16: 489-496.
  • Timmermans JP, Hens J, Adriaensen D (2001) Outer submucous plexus: an intrinsic nerve network involved in both secretory and motility processes in the intestine of large mammals and humans. Anat Rec 262: 71-78.
  • Vasina V, Barbara G, Talamonti L, Stanghellini V, Corinaldesi R, Tonini M, De Ponti F, De Giorgio R (2006) Enteric neuroplasticity evoked by inflammation. Auton Neurosci 126-127: 264-272.
  • Verma N, Rettenmeier AW, Schmitz-Spanke S (2011) Recent advances in the use of Sus scrofa (pig) as a model system for proteomic studies. Proteomics 11: 776-793.
  • Wierup N, Gunnarsdóttir A, Ekblad E, Sundler F (2007) Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glands. BMC Neurosci 8: 51
Typ dokumentu
Bibliografia
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