Involvement of the different extracts from roots of Salvia miltiorrhiza Bunge on acute hypobaric hypoxia-induced cardiovascular effects in rats – preliminary report

• Autorzy: Buchwald W. , Mikolajczak P. L. , Krajewska-Patan A. , Dreger M. , Gorska-Paukszta M. , Szulc M. , Polcyn P. , Piorunska-Mikolajczak A. , Mielcarek S. , Czerny B. , Mrozikiewicz P. M. , Bobkiewicz-Kozlowska T.
• Języki publikacji: EN

Abstrakty

EN

The present study was carried out to investigate the protective effects of roots of Salvia miltiorrhiza Bunge on hypobaric hypoxia. Two extracts of S. miltiorrhiza (extract 1: ethanol : water - 50 : 50; extract 2: 96% ethanol) were used. The experiments were performed after 7 consecutive days of administration of the extracts (200 mg/kg b.w., intragastrically) to male Wistar rats. Next, after placing animals for 60 min in the controlled acute hypobaric hypoxia (500 mm Hg) the systolic arterial blood pressure (SAP) in conscious rats, bioelectric heart activity in unconscious rats and analysis of oxidative stress parameters in the blood of rats: malonyldialdehyde (MDA) and lipid peroxidase (LPO) concentration, activity of superoxide dismutase (SOD) or glutathione peroxidase (GPX) were assayed. It was found out that the extract 1 augmented the lowering of SAP shown in hypoxia affected control rats. On the contrary the extract 2 reversed SAP to values obtained in control animals. Moreover, both extracts led to the normalization of hypoxia-induced tachycardia and levels of MDA, LPO and SOD. It seems that the above-mentioned effects are coupled with different active compounds content in the extracts, however more studies are needed to confirm this hypothesis.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2012
• Tom: 15
• Numer: 4
• Opis fizyczny: p.693-701,ref.

Twórcy

autor

Buchwald W.

• Team of Botany and Agriculture of Medicinal Plants, Department of Botany, Breeding and Agriculture, Institute of Natural Fibres and Medicinal Plants, Kolejowa 2, 62-064 Plewiska, Poland

autor

Mikolajczak P. L.

• Department of Pharmacology and Experimental Biology, Institute of Natural Fibres and Medicinal Plants, Libelta 27, 61-707 Poznań, Poland
• Department of Pharmacology, Poznań University of Medical Sciences, Rokietnicka 5a, 60-806 Poznań, Poland

autor

Krajewska-Patan A.

• Department of Pharmacology and Experimental Biology, Institute of Natural Fibres and Medicinal Plants, Libelta 27, 61-707 Poznań, Poland

autor

Dreger M.

• Department of Biotechnology, Institute of Natural Fibres and Medicinal Plants, Wojska Polskiego 71b, 60-630 Poznań, Poland

autor

Gorska-Paukszta M.

• Department of Quality Control of Medicinal Products and Dietary Supplements, Institute of Natural Fibres and Medicinal Plants, Libelta 27, 61-707 Poznań, Poland

autor

Szulc M.

• Department of Pharmacology, Poznań University of Medical Sciences, Rokietnicka 5a, 60-806 Poznań, Poland

autor

Polcyn P.

• Department of Pharmacology, Poznań University of Medical Sciences, Rokietnicka 5a, 60-806 Poznań, Poland

autor

Piorunska-Mikolajczak A.

• Laboratory of Lipid Metabolism, Department of General Chemistry, Poznań University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland

autor

Mielcarek S.

• Department of Quality Control of Medicinal Products and Dietary Supplements, Institute of Natural Fibres and Medicinal Plants, Libelta 27, 61-707 Poznań, Poland

autor

Czerny B.

• Institute of Natural Fibres and Medicinal Plants, Libelta 27, 61-707 Poznań, Poland
• Department of General Pharmacology and Pharmacoeconomy, Pomeranian Medical University, Żołnierska 48, 70-204 Szczecin, Poland

autor

Mrozikiewicz P. M.

• Department of Quality Control of Medicinal Products and Dietary Supplements, Institute of Natural Fibres and Medicinal Plants, Libelta 27, 61-707 Poznań, Poland
• Laboratory of Experimental Pharmacogenetics, Department of Clinical Pharmacy and Biopharmacy, Poznań University of Medical Sciences, Marii Magdaleny 14, 60-861 Poznań, Poland

autor

Bobkiewicz-Kozlowska T.

• Department of Pharmacology, Poznań University of Medical Sciences, Rokietnicka 5a, 60-806 Poznań, Poland

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