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2014 | 03 |
Tytuł artykułu

Hepatoprotective and antioxidant activity of Lannea coromandelica Linn. on thioacetamide induced hepatotoxicity in rats

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Hepatoprotective and antioxidant activity of Lannea coromandelica bark extract (LCBE) was investigated on thioacetamide induced hepatotoxicity in rats. Hepatotoxicity was induced by thioacetamide (TAA) administration (100 mg/kg. s.c). LCBE at different doses (400 and 200 mg/kg) were administered orally to male wistar rats. Thioacetamide caused elevation of serum concentration of AST, ALT, ALP, serum bilirubin and also reduced serum concentration of total protein, albumin, sodium, potassium in animals as compared to control (p < 0.05) but LCBE treated rats showed maximum reduction of AST [(138±5.1) IU/L], ALT [(71 ±2.7) IU/L], ALP [(140 ±1.9) IU/L] with the high dose (400 mg/kg bw) of combined aqueous and alcoholic bark extract. Whereas, serum bilurubin, cholesterol, sugar and LDH content were varied with the treatments but showed higher with the only ethanolic extract at dose of 400 mg/kg. The IC50 value was observed as (83.28 ±2.12) μg/mL, for DPPH radical scavenging activity. Result concluded that ethanolic extract and combined aqueous and alcoholic bark extract of L. coromandelica showed a potential hepatoprotective and antioxidant activities might be due to the presence of phenolic groups, terpenoids and alkaloids.
Wydawca
-
Rocznik
Tom
03
Opis fizyczny
p.30-43,fig.,ref.
Twórcy
  • St.John’s Pharmacy College, 6, II Main, Vijaya Nagar, Bangalore - 560104, India
  • St.John’s Pharmacy College, 6, II Main, Vijaya Nagar, Bangalore - 560104, India
autor
  • Krupanidhi College of Pharmacy, 12/1, Chikka Bellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, India
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-801e006a-fd6f-46c8-bacd-e3870fbcefd5
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