Hepatoprotective and antioxidant activity of Lannea coromandelica Linn. on thioacetamide induced hepatotoxicity in rats

• Autorzy: Srinivasa Rao V. , Wilkin Einstein J. , Das K.
• Języki publikacji: EN

Abstrakty

EN

Hepatoprotective and antioxidant activity of Lannea coromandelica bark extract (LCBE) was investigated on thioacetamide induced hepatotoxicity in rats. Hepatotoxicity was induced by thioacetamide (TAA) administration (100 mg/kg. s.c). LCBE at different doses (400 and 200 mg/kg) were administered orally to male wistar rats. Thioacetamide caused elevation of serum concentration of AST, ALT, ALP, serum bilirubin and also reduced serum concentration of total protein, albumin, sodium, potassium in animals as compared to control (p < 0.05) but LCBE treated rats showed maximum reduction of AST [(138±5.1) IU/L], ALT [(71 ±2.7) IU/L], ALP [(140 ±1.9) IU/L] with the high dose (400 mg/kg bw) of combined aqueous and alcoholic bark extract. Whereas, serum bilurubin, cholesterol, sugar and LDH content were varied with the treatments but showed higher with the only ethanolic extract at dose of 400 mg/kg. The IC50 value was observed as (83.28 ±2.12) μg/mL, for DPPH radical scavenging activity. Result concluded that ethanolic extract and combined aqueous and alcoholic bark extract of L. coromandelica showed a potential hepatoprotective and antioxidant activities might be due to the presence of phenolic groups, terpenoids and alkaloids.

Słowa kluczowe

EN

hepatoprotective activity; antioxidant activity; biochemical parameter; Lannea coromandelica; thioacetamide; hepatotoxicity; rat

• Wydawca: -
• Czasopismo: International Letters of Natural Sciences
• Rocznik: 2014
• Tom: 03
• Opis fizyczny: p.30-43,fig.,ref.

Twórcy

autor

Srinivasa Rao V.

• St.John’s Pharmacy College, 6, II Main, Vijaya Nagar, Bangalore - 560104, India

autor

Wilkin Einstein J.

• St.John’s Pharmacy College, 6, II Main, Vijaya Nagar, Bangalore - 560104, India

autor

Das K.

• Krupanidhi College of Pharmacy, 12/1, Chikka Bellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, India

Bibliografia

• [1] F. M. Ward, M. J. Daly, Churchill Livingstone, New York, (1999) 195-212.
• [2] B. Sharma, U. K. Sharma, Int. J Pharm Tech Res 1 (2009) 1330-34.
• [3] M. S. Akhtar, M. Amin, M. Ahmad, Ethnobotanical Leaflets 13 (2009) 310-15.
• [4] P. G. Pearson, L. C. Wienkers, Handbook of Drug Metabolism (2009) 64-69.
• [5] G. M. Cragg, D. J. Newman, K. M. Snader, Journal of Natural Products 60 (1997) 52-60.
• [6] S. A. Ali, T. H. Al-amin, A. H. Mohamed, A. A. Gameel, J. Pharmacol and Toxicol 4 (2009) 167-72.
• [7] A. Bahar, A. Tanveer, A. K. Shah, J ethnopharmacol 76 (2001) 187-189.
• [8] M. Yusuf, J. Begum, M. N. Hoque, J. U. Chowdhury, Bangladesh Council of Scientific and Industrial Research (2009).
• [9] M. T. Islam, S. Tahara, Phytochemistry 54 (2000) 901-907.
• [10] G. Pandeya, Chaukhambha Sanskrit Sansthan (1997).
• [11] C. K. Kokate, Practical Pharmacology 4 (1996) 107-112.
• [12] S. K. Ashok, S. N. Somayaji, K. L. Bairy, Indian J. Ppharmacol 32 (2001) 260-266.
• [13] S. Baros, M. Karsayova, K. Jomova, A. Gaspar, M. Valko, Journal of Microbiology Biotechnol Food Sci 1 (2012) 725-732.
• [14] G. Kumar, G. Sharmila Banu, P. Vanitha Pappa, M. Sundararajan, M. Rajasekara Pandian, J Ethnopharmacol 92 (2004) 37-40.
• [15] B. Jayaprakasam, Y. Zhang, M. G. Nair, J. Agric. Food Chem 52 (2004) 6939-6943.
• [16] T. Vani, M. Rajini, S. Sarkar, CJ. Shishoo, Int. J. Pharmac 35 (1997) 313-317.
• [17] B. Auddy, M. Ferreira, F. Blasina, L. Lafon, F. Arredondo, F. Dajas, P. C. Tripathi, T. Seal, B. Mukherjee, J. Ethnopharmacol 84 (2003) 131-138.
• [18] P. Kumar, G. D. Rao, S. R. Setty, Pharmacologyonline 3 (2008) 181-189.
• [19] C. K. Roy, J. V. Kamath, M. Asad, Ind J Exp Bio 44 (2006) 35-41.
• [20] T. Kelly, GUT 27 (1986) 339-349.
• [21] E. I. Rubin, Essential pathology, Lippincott Williams & Wilkins 14 (1995) 393-440.
• [22] S. K. Mitra, M. V. Venkataranganna, R. Sundarin, S. Gopumadhavan, J Ethnopharmacol 63 (1998) 181-186.
• [23] M. Muthulingam, P. D. Savio, T. S. Seeli, N. Indra, S. Sethupathy, Int J Cur Res 5 (2010) 41-46.
• [24] V. Nikolaev, M. Kerimova, E. Naydenova, E. Ivanov, D. Adjarov, Toxicol 48 (1988) 81-85.
• [25] M. Hajimahmoodi, N. Sadehi, B. Jannat, M. R. Oveisi, S. Madani, J Biol Sci 8(2008) 779-783.