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2015 | 71 | 04 |
Tytuł artykułu

Anesthesia with intraperitoneal tiletamine/zolazepam, xylazine, and tramadol in mice

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
A safe and reliable method for anesthetizing mice is very important for biomedical researches. The goals of this research were to find a safe intraperitoneal injection anesthesia protocol coupled with quick recovery for mice surgery. This study was carried out to compare the anesthesia effect of a combination of tiletamine/zolazepamxylazine-tramadol (TZXT) and tiletamine/zolazepam-xylazine (TZX) combinations and of the TZXT protocol plus atipamezole, given 30 min later to reverse xylazine (TZXTA). Sixty mice were immobilized by TZX, TZXT, and TZXTA on three different occasions. The immobilization and analgesia scores, as well as baseline physiological parameters of the mice (heart rate and respiratory rate) were determined. All 3 combinations effectively induced anesthesia, and the mice assumed lateral recumbency within 5 min. Changes in physiological parameters after the administration of the drug combinations remained within biologically acceptable limits. Although both TZX and TZXT appeared to be effective intraperitoneal anesthetic combinations, TZXT provided significantly better analgesia with a longer duration than TZX. Atipamezole administration provided effective antagonism, and no adverse effects were observed in this study.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
71
Numer
04
Opis fizyczny
p.219-223,fig.,ref.
Twórcy
autor
  • Heilongjiang Institute of Veterinary Science, Qiqihaer, Heilongjiang 161006, P. R. China
autor
  • Clinical Veterinary Medicine, College of Veterinary Medicine, Northwest A&F Univeristy, Yangling, Shaanxi 712100, P. R. China
autor
  • Department of Veterinary Surgery, College of Veterinary Medicine; Northeast Agricultural University, Harbin, Heilongjiang 150030, P. R. China
autor
  • Department of Veterinary Surgery, College of Veterinary Medicine; Northeast Agricultural University, Harbin, Heilongjiang 150030, P. R. China
autor
  • Department of Veterinary Surgery, College of Veterinary Medicine; Northeast Agricultural University, Harbin, Heilongjiang 150030, P. R. China
autor
  • Clinical Veterinary Medicine, College of Veterinary Medicine, Northwest A&F Univeristy, Yangling, Shaanxi 712100, P. R. China
Bibliografia
  • 1. Alves H. N., da Silva A. L., Olsson I. A., Orden J. M., Antunes L. M.: Anesthesia with intraperitoneal propofol, medetomidine, and fentanyl in rats. J. Am. Assoc.Lab. Anim. Sci. 2010, 49, 454-459.
  • 2. Arras M., Autenried P., Rettich A., Spaeni D., Rülicke T.: Optimization of intraperitoneal injection anesthesia in mice: drugs, dosages, adverse effects,and anesthesia depth. Comp. Med. 2001, 51, 443-456.
  • 3. Baker N. J., Schofield J. C., Caswell M. D., McLellan A. D.: Effects of early atipamezole reversal of medetomidine-ketamine anesthesia in mice. J. Am.Assoc. Lab. Anim. Sci. 2011, 50, 916-920.
  • 4. Bentson K. L., Capitanio J. P., Mendoza S. P.: Cortisol responses to immobilization with Telazol or ketamine in baboons (Papio cynocephalus/anubis)and rhesus macaques (Macaca mulatta). J. Med. Primatol. 2003, 32, 148-160.
  • 5. Burnside W. M., Flecknell P. A., Cameron A. I., Thomas A. A.: A comparison of medetomidine and its active enantiomer dexmedetomidine when administeredwith ketamine in mice. BMC Vet. Res. 2013, 9, 48.
  • 6. Choi W., Jang H. S., Yun S. H., Park J. S., Kwon Y. S., Jang K. H.: Effect of tramadol on medetomidine and ketamine anesthesia in dogs. Pak. Vet. J. 2011,31, 99-104.
  • 7. Egger C. M., Souza M. J., Greenacre C. B., Cox S. K., Rohrbach B. W.: Effect of intravenous administration of tramadol hydrochloride on the minimumalveolar concentration of isoflurane in rabbits. Am. J. Vet. Res. 2009, 70,945-949.
  • 8. Gargiulo S., Greco A., Gramanzini M., Esposito S., Affuso A., Brunetti A., Vesce G.: Mice anesthesia, analgesia, and care, Part I: anesthetic considerations in preclinical research. ILAR J. 2012, 53, E55-E69.
  • 9. Grubb M. C., Stornetta R. L., Pence R., Baertschi A. J., Guyenet P. G.: Antagonist precipitated clonidine withdrawal in rat: effects on locus coeruleusneurons, sympathetic nerves and cardiovascular parameters. J. Auton Nerv.Syst. 1998, 71, 85-95.
  • 10. Janssen B. J., De Celle T., Debets J. J., Brouns A. E., Callahan M. F., Smith T. L.: Effects of anesthetics on systemic hemodynamics in mice. Am. J. Physiol. Heart Circ. Physiol. 2004, 287, H1618-H1624.
  • 11. Kawai S., Takagi Y., Kaneko S., Kurosawa T.: Effect of three types of mixed anesthetic agents alternate to ketamine in mice. Exp. Anim. 2011, 60, 481-487.
  • 12. Kim J. M., Park C. S., Jun M. H., Kim M. C.: Antagonistic effects of yohimbine in pigs anaesthetized with tiletamine/zolazepam and xylazine. Vet. Rec. 2007,161, 620-624.
  • 13. Kirihara Y., Takechi M., Kurosaki K., Kobayashi Y., Kurosawa T.: Anesthetic effects of a mixture of medetomidine, midazolam and butorphanol in twostrains of mice. Exp. Anim. 2013, 62(3), 173-180.
  • 14. Lin H. C., Thurmon J. C., Benson G. J., Tranquilli W. J.: Telazol: a review of its pharmacology and use in veterinary medicine. J. Vet. Pharmacol. Ther.1993, 16, 383-418.
  • 15. Lu D. Z., Fan H. G., Kun M., Song Z. L., Ming Y. S., Sheng J., Wang H. B.: Antagonistic effect of atipamezole, flumazenil and naloxone following anaesthesiawith xylazine, tramadol and tiletamine/zolazepam combinations inpigs. Vet. Anaesth. Analg. 2011, 38, 301-309.
  • 16. Lu D. Z., Qin S. H., Ma X. W., Wang H. Y., Ma B. H.: Tramadol effect on the ketamine-medetomidine combination in immature Bamei pigs. Med. Weter. 2013, 69, 165-170.
  • 17. Pertovaara A., Haapalinna A., Sirviö J., Virtanen R.: Pharmacological properties, central nervous system effects, and potential therapeutic applicationsof atipamezole, a selective alpha2-adrenoceptor antagonist. CNS Drug Rev.2005, 11, 273-288.
  • 18. Rioja E., Kerr C. L., Enouri S. S., McDonell W. N.: Sedative and cardiopulmonary effects of medetomidine hydrochloride and xylazine hydrochloride and their reversal with atipamezole hydrochloride in calves. Am. J. Vet. Res. 2008, 69, 319-329.
  • 19. Tendillo F. J., Mascías A., Santos M., Segura I. A., San Román F., CastilloOlivares J. L.: Cardiopulmonary and analgesic effects of xylazine, detomidine,medetomidine, and the antagonist atipamezole in isoflurane-anesthetizedswine. Lab. Anim. Sci. 1996, 46, 215-219.
  • 20. Zhang Y., Du L., Pan H., Li L., Su X.: Enhanced analgesic effects of propacetamol and tramadol combination in rats and mice. Biol. Pharm. Bull. 2011, 34, 349-353.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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