Role of mucus in gastric mucosal protection

• Autorzy: Slomiany B.L. , Slomiany A.
• Języki publikacji: EN

Abstrakty

EN

Even though there is no general agreement as to the mechanism of gastric mucosal protection, the consensus is that the initial brunt of luminal insults falls on the mucus layer which constitutes the only identifiable physical barrier between the gastric lumen and the mucosal surface. The continuous renewal and resilient nature of this layer efficiently counters peptic erosion of the gel, assures its viscoelastic and permselective properties, and provides a milieu for containment of the diffusing luminal acid by mucosal bicarbonate. Disturbances in this delicate balance lead to the impairment of the protective function of mucus resulting in gastric disease. Indeed, the weakening of gastric mucosal defense is intimately associated with the diminished viscoelastic qualities of mucus, decrease in hydrogen ion retardation capacity, and the extensive proteolysis of its mucin component. Although until recently the disintegration of the mucus coat was attributed exclusively to the enhanced activity of intragastric pepsin, our studies provided strong argument that a bacterial factor, namely infection by Helicobacter pylori, through the action of its protease and. lipase enzymes also is highly detrimental to the integrity of gastric mucus. Hence, agents capable of interfering with the pathogenic activity of this bacteria are becoming the drugs of choice in peptic ulcer therapy.

Słowa kluczowe

EN

gastric mucosal protection; Helicobacter pylori; mucosal surface; peptic erosion; viscoelastic property; mucosal bicarbonate secretion; gastric disease; antiulcer agent

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1991
• Tom: 42
• Numer: 2
• Opis fizyczny: p.147-161,fig.,ref.

Twórcy

autor

Slomiany B.L.

• Research Center, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103-2400, USA

autor

Slomiany A.

• Research Center, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103-2400, USA

Bibliografia

• 1. Szabo S, Pihan G, Triers S. Alteration in blood vessels during gastric injury and protection. Scand J Gastroenterol 1986; suppl 125; 21: 92-96.
• 2. Allen A. Mucus - a protective secretion of complexity. Trends Biochemf Sci 1983; 8: 163-173.
• 3. Slomiany BL, Sarosiek J, Slomiany A. Gastric mucus and the mucosal barrier. Dig Dis 1987; 5: 125-145.
• 4. Flemstrom G. Gastric and duodenal mucosal bicarbonate seeretion. In: Johnson LR, ed. Physiology of the gastrointestinal tract. New York: Raven Press 1987; 1055- 1069.
• 5. Slomiany BL, Murty VLN, Piotrowski J, Slomiany A. Effect of antiulcer agents on the physicochemical properties of gastric mucus. In: Chantler E, Ratcliffe NA, eds. Mucus and related topics. Cambridge: Company Biologists Ltd. 1989; 179-191.
• 6. Evans DG, Evans DJ, Moulds J J, Graham DY. N-acetylneuraminylactose-binding fibrillar hemagglutinin of Campylobacter pylori: a putative colonization factor antigen. Infect Immun 1988; 56: 2896-2906.
• 7. Emody L, Carlsson A, Ljungh A, Wadstrom T. Mannoseresistant hemagglutination by Campylobacter pylori. Scand J Infect Dis 1988; 20: 353-354.
• 8. Lingwood CA, Pellizzari A, Lauw M, Sherman P, Drumm B. Gastric glycerolipid as a receptor for Campylobacter pylori. Lancet 1989; 87: 238-242.
• 9. Slomiany BL, Piotrowski J, Samanta A, VanHorn K, Murty VLN, Slomiany A. Campylobacter pylori colonization factor shows specificity for lactosylceramide sulfate and GM3 ganglioside. Biochem Internatl 1989; 19: 929-936.
• 10. Slomiany A, Yano S, Slomiany BL, Glass GBJ. Lipid composition of the gastric mucous barrier in the rat. J Biol Chem 1978; 253: 3785-3791.
• 11. Slomiany BL, Piasek A, Slomiany A. The role of surface and preformed intracellular mucus in gastric mucosal protection. Scand J Gastroenterol 1986; 20: 1191-1196.
• 12. Kosmala M, Carter SR, Konturek, SJ, Slomiany A, Slomiany BL. Mucus glycoprotein secretion by duodenal mucosa in response to luminal arachidonic acid. Bioehim Biophys Acta 1986; 884: 419-428.
• 13. Witas H, Slomiany BL, Zdebska E, Kojima K, Liau YH, Slomiany A. Lipids associated with dog gastric mucus glycoprotein. J Appl Biochem 1983; 5: 16-24.
• 14. Slomiany A, Jozwiak Z, Takagi A, Slomiany BL. The role of covalently bound fatty acids in the degradation of human gastric mucus glycoprotein. Arch Biochem Biophys 1984; 229: 560-567.
• 15. Slomiany BL, Takagi A, Liau YH, Jozwiak Z, Slomiany A. In vitro acylation of rat gastric mucus glycoprotein with ³ H-palmitic acid. J Biol Chem 1984; 259: 11997- 12000.
• 16. Liau YH, Slomiany BL, Slomiany A, Piasek A, Palmer D, Rosenthal WS. Identification of mucus glycoprotein fatty acyltransferase activity in human gastric mucosa. Digestion 1985; 32: 57-62.
• 17. Lichtenberger LM, Graziani LA, Dial EJ, Butler BD, Hills BA. Role of surface-active phospholipids in gastric cytoprotection. Science 1983; 219: 1327-1329.
• 18. Hills BA. Gastric mucosal barrier: stabilization of hydrophobic lining of the stomach by mucus. Am J Physiol 1985; 249: 6343-6348.
• 19. Kao YC, Lichtenberger LM. Localization of phospholipid-rich zones in rat gastric mucosa: possible origin of a protective hydrophobic luminal lining. J. Histochem Cytochem 2987; 35: 1285-1298.
• 20. Goggin PM, Ahmed H, Northfield TC. Molecular basis for gastric mucosal hydro-phobicity. Gastroenterology 1990; 98: 48.
• 21. Gwozdzinski K, Slomiany A, Nishikawa H, Okazaki K, Slomiany BL. Gastric mucin hydrophobicity: effects of associated and covalently bound lipids, proteolysis and reduction. Biochem Internatl 1988; 17: 907-917.
• 22. Yuonan F, Pearson J. Allen A, Venebles C. Changes in the structure of the mucus gel on the mucosal surface of the stomach in association with peptic ulcer disease. Gastroenterology 1982; 88: 827-831.
• 23. Slomiany BL, Bilski J, Sarosiek J, Murty VLN, Dworkin B, VanHorn K, Zielenski J, Slomiany A. Campylobacter pyloridis degrades mucin and and undermines gastric mucosal integrity. Biochem Biophys Res Commun 1987; 144: 307-314.
• 24. Sarosiek J, Slomiany A, Slomiany BL. Evidence for weakening of gastric mucus integrity by Campylobacter pylori. Scand J Gastroent. 1988; 23: 585-590.
• 25. Slomiany BL, Nishikawa H, Piotrowski J, Okazaki K, Slomiany A. Lipolytic activity of Campylobacter pylori: effect of sofalcone. Digestion 1989; 43: 33-40.
• 26. Slomiany BL, Kasinathan C, Slomiany A. Lipolytic activity of Campylobacter pylori: effect of colloidal bismuth subcitrate (De-Nol). Am J Gastroent 1989; 84: 506-510.
• 27. Barrett-Bee K, Hayes Y, Wilson RG, Ryler JF. A comparison of phospholipase activity, cellular adherence and pathogenicity of yeasts. J. Gen Microbiol 1985; 131: 1217-1221.
• 28. Rollof J, Craconier JH, Soderstorm C, Nillson-Ehle P. Interference of Staphylococcus aureus lipase with human granalocyte function. Eur J Clin Microbiol Infect Dis 1988; 7: 505-510.
• 29. Rollof J, Hedstrom SA, Nilsson-Ehle P. Lipolytic activity of Staphylococcus aureus strains from disseminated and localized infections. Acta Path Microbiol Scand 1987; 95: 109-113.
• 30. Slomiany BL, Liau YH, Laszewicz W, Slomiany A. Lysolecithin affects the viscosity permeability and peptic susceptibility of gastric mucin. Scand J Gastroent 1986; 21: 1073-1079.
• 31. Slomiany BL, Glass GBJ, Kojima K, Banas-Gruszka Z, Slomiany A. Effect of lysolecithin on the constituents of gastric mucus. In: Chandler EN, Elder JB, Elstin M, eds. Mucus in health and disease-II. New York: Plenum Press. 1982; 163-174.
• 32. Beachy EH. Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. J Infect Dis 1981; 143: 325-345.
• 33. Piotrowski J, Slomiany BL, VanHorn K, Sengupta S, Slomiany A. Sulfated mucins and sucralfate inhibit hemagglutination of erythrocytes by C. pylori. Gastroenterology 1990; 98: 107.
• 34. Marshall В J, Armstrong JA, Graham JF, et al. Antibacterial action of bismuth inrelation to Campylobacter pyloridis colonization and gastritis. Digestion 1987;, 37: 16-30.
• 35. Sarosiek J, Bilski J, Mnrty VLN, Slomiany A, Slomiany BL. Colloidal bismuth subcitrate (De-Nol) inhibits degradation of gastric mucus by Campylobacter pylori protease. Am J Gastroenterol 1989; 84: 506-510.
• 36. Slomiany BL, Nishikawa H, Bilski J, Slomiany A. Colloidal bismuth subcitrate inhibits peptic degradation of gastric mucus and epidermal growth factor in vitro. AM J Gastroenterol 1990; 85: 390-393.