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2020 | 80 | 3 |
Tytuł artykułu

Diazepam and electrical stimulation of paleocerebellar cortex inhibits seizures in pentylenetetrazol‑kindled rats

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The cerebellum is a potent anti‑epileptic target for deep brain stimulation in patients with drug‑resistant epilepsy. The effects of such stimulation, however, may also favor seizure activity. Our goal was to investigate the effect of cerebellar electrical stimulation (ES) alone and in combination with the anti‑epileptic drug diazepam (DIA) on seizure outcome. We used a rat model of pentylenetetrazol kindling, which is characterized by seizures followed by deteriorations in central benzodiazepine‑GABAA (BDZ‑GABAA) receptors. We tested the effects of ES alone and in combination with DIA (0.1 and 1.0 mg/kg) on seizures. Our data demonstrated: 20 ES trials can prevent the recurrence of clonic‑tonic kindled seizures, administration of either DIA‑0.1 or ES (5 trials) alone is ineffective on seizures, and combining DIA‑0.1 and 5 ES or DIA‑1.0 and 5 ES caused an additive effect, prolonged the latency to seizure onset, and prevented recurrence of clonic‑tonic seizures. We also observed that ES alone produced either facilitation or inhibition of seizures on EEG. In contrast, the same ES inhibited EEG seizures when delivered after a combination of DIA‑1.0 and 5 ES and ultimately prevented the facilitation of the discharges. Lastly, we demonstrated that seizure suppression is intensified when cortical ES is performed after DIA administration. Our data supported the hypothesis that both BDZ‑GABAA receptor activity along with cerebellar output comprise the potential mechanisms underlying the peculiar effects of deep brain stimulation in the cerebellum on seizures.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
80
Numer
3
Opis fizyczny
p.322-330,fig.,ref.
Twórcy
  • Department of Biophysics, Informatics and Medical Devices, Odessa National Medical University, Odessa, Ukraine
autor
  • Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA
autor
  • Department of Simulative Medicine, Odessa National Medical University, Odessa, Ukraine
autor
  • Department of Physiology, Odessa National Medical University, Odessa, Ukraine
Bibliografia
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
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