EN
The aim of the study was to develop a sensitive analytical method that enables to determine cefacetril concentration in milk after its application to the udders, as well as to establish and compare cefacetril’s basic pharmacokinetic indicators after its intramammary application to cows with inflammed and healthy udders. The content of cefacetril was determined with the use of high-performance liquid chromatography with UV detection. Usefulness of the developed analytical method in the studies of pharmacokinetics of cefacetril has been demonstrated. Results obtained during the statistical analysis and bacteriological examinations allowed to regard the antibiotic as an accurately selected medical product used in the treatment of mastitis in cows.