Transducing neuronal activity at multiple scales: emerging opportunities from neuroelectronics and nanostructures

• Autorzy: Berdondini L.
• Języki publikacji: EN

Abstrakty

EN

Brain functions and pathological dysfunctions emerge over time by involving a complex dynamics of intracellular and intercellular signalling interactions. This signalling involves multiple and interrelated spatial and temporal scales and it occurs within large cellular networks formed by heterogeneous types of connected and variable spiking neurons. The challenge of developing neurotechnologies enabling to precisely monitor and selectively perturb these biological signals at cellular and possibly sub-cellular resolutions within large networks has occupied neuroscientists and engineers for decades, but current methods are still limited. In particular, while techniques for perturbing neuronal signals by acting at molecular or cellular scales have remarkably progressed over recent years, resolving and monitoring these signals at multiple scales simultaneously within cellular networks and brain circuits remains a fundamental challenge. We aim at developing neurotechnologies and experimental methodologies for monitoring neuronal signals within neuronal systems in vitro and brain circuits in vivo, and able to resolve the signal contribution of a large number of single neurons. Our methodology consists in realizing planar and micro-structured microelectronic devices providing dense arrays of microelectrodes and on-chip circuits for signal conditioning and multiplexing. We are also exploring the potential of on-chip plasmonic 3D nanostructures for chemical spectroscopy, cell poration and nanofluidic intracellular interfacing. In this seminar, I will present results achieved so far by applying CMOS electrode array devices on increasingly complex in vitro and ex vivo neuronal systems as well as very recent results obtained with the ongoing development of implantable CMOS-probes. This will illustrate emerging experimental opportunities offered by these emerging devices for neuroscience research and applications. FINANCIAL SUPPORT: This work was partially supported by the NIH Brain Initiative (grant U01NS094190-01) and by the 7th Framework Programme for Research of the European Commission, under the Future and Emerging Technologies (FET) programme (projects RENVISION, GA n° 600847, Neuro-bio-inspired systems (NBIS) FET-Proactive Initiative; SI-CODE, GA n° 284553, FET-OPEN) and under the NAMASEN (GA n° 264872) Marie-Curie Initial Training Network.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2017
• Tom: 77
• Numer: Suppl.1
• Opis fizyczny: p.33-34

Twórcy

autor

Berdondini L.

• Department of Neuroscience and Brain Technologies, Fondazione Istituto Italiano di Tecnologia, Genova, Italy