Regulation of angiogenesis by hypoxia: the role of microRNA

• Autorzy: Madanecki P. , Kapoor N. , Bebok Z. , Ochocka R. , Collawn J. F. , Bartoszewski R.
• Języki publikacji: EN

Abstrakty

EN

Understanding the cellular pathways that regulate angiogenesis during hypoxia is a necessary aspect in the development of novel treatments for cardiovascular disorders. Although the pathways of angiogenesis have been extensively studied, there is limited information on the role of miRNAs in this process. miRNAs or their antagomirs could be used in future therapeutic approaches to regulate hypoxia-induced angiogenesis, so it is critical to understand their role in governing angiogenesis during hypoxic conditions. Although hypoxia and ischemia change the expression profile of many miRNAs, a functional role for a limited number of so-called hypoxamiRs has been demonstrated in angiogenesis. Here, we discuss the best examples that illustrate the role of hypoxamiRs in angiogenesis.

Słowa kluczowe

EN

regulation; angiogenesis; hypoxia; microRNA; cardiovascular disorder; treatment; gene expression; human disease

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2013
• Tom: 18
• Numer: 1
• Opis fizyczny: p.47-57,fig.,ref.

Twórcy

autor

Madanecki P.

• Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, Gdansk, Poland

autor

Kapoor N.

autor

Bebok Z.

autor

Ochocka R.

• Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, Gdansk, Poland

autor

Collawn J. F.

autor

Bartoszewski R.

• Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, Gdansk, Poland

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