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2014 | 74 | 1 |
Tytuł artykułu

Role of the blood - brain barrier in differential response to opioid peptides and morphine in mouse lines divergently bred for high and low swim stress - induced analgesia

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Over 20 years ago, the Sadowski group separated two mouse lines, one with high (HA) and the other with low (LA) sensitivity to swim stress-induced analgesia (SSIA). Recently, we proposed that increased leakage of the blood-brain barrier (BBB) in the HA line created the difference in the response to SSIA. To search for further evidence for this hypothesis, differences in the levels of the BBB proteins occludin and claudin-5 were analysed. In addition, we sought to evaluate practical differences in BBB permeability by examining the antinociceptive levels in HA and LA mouse lines after i.v. administration of peptides that have limited access to the CNS. Western blot was used to analyse the differences between occludin and claudin-5. To evaluate the functional differences between the BBB of HA and LA mice, the antinociception levels of endomorphin I, biphalin and AA2016 (peptides with limited BBB permeabilities) in the tail flick test were examined. The expression levels of occludin and claudin-5 in the HA mouse line were lower than in the LA and control mice. Central antinociception of the opioid peptides were significantly higher in the HA line than in the LA and control lines. Our data support the hypothesis that BBB leakage is responsible for the differences between the HA and LA mouse lines. Although SSIA confirmed BBB differences between both lines, it is not limited to the opioid system and could be a useful model for studying the role of the BBB in molecular communications between the periphery and CNS.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
74
Numer
1
Opis fizyczny
p.26-32,fig.,ref.
Twórcy
autor
  • Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
autor
  • Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary
autor
  • Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
  • Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
  • Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland
autor
  • Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
autor
  • Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary
autor
  • Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary
  • Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
  • Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
  • Tufts University School of Medicine, Boston, MA, USA
Bibliografia
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  • Gajkowska B, Kosson A, Sacharczuk M, Kosson P, Lipkowski AW (2011) Blood-brain barier permeability differentiates two mouse lines divergently bred for high (HA) and low (LA) swim stress-induced analgesia: elec¬tron microscopy analysis. [Primary: Blood-brain barrier permeability differentiates Sadowski Mouse lines of high and low stress-induced analgesia. Electron microscopy analysis]. Folia Neuropathol 49: 311-318.
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  • Krizbai IA, Lenzser G, Szatmari E, Farkas AE, Wilhelm I, Fekete Z, Erdos B, Bauer H, Bauer HC, Sandor P, Komjati K (2005) Blood-brain barrier changes during compensated and decompensated hemorrhagic shock. Shock 24: 428-433.
  • Lossinsky AS, Shivers RR (2004) Structural pathways for macromolecular and cellular transport across the blood- brain barrier during inflammatory conditions. Review. Histol Histopathol 19: 535-564.
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  • Sacharczuk M, Lesniak A, Korostynski M, Przewlocki R, Lipkowski A, Jaszczak K, Sadowski B (2010a) A poly¬morphism in exon 2 of the delta-opioid receptor affects nociception in response to specific agonists and antago¬nists in mice selectively bred for high and low analgesia. Pain 149: 506-513.
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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