Inhibition of multidrug-resistant Gram-positive and Gram-negative bacteria by a photoactivated porphyrin

• Autorzy: Bondi M. , Mazzini A. , De Niederhausern S. , Iseppi R. , Messi P.
• Języki publikacji: EN

Abstrakty

EN

The authors studied the in vitro antibacterial activity of the photo-activated porphyrin meso-tri(N-methyl-pyridyl), mono(N-tetradecyl-pyridyl)porphine (C14) against four multidrug-resistant bacteria: Staphylococcus aureus, Enterococcus faecalis (Gram-positive), Escherichia coli, Pseudomonas aeruginosa (Gram-negative). Using 10 μg/ml of porphyrin and 60 sec irradiation we observed the remarkable susceptibility of S. aureus and E. faecalis to treatment while, under the same conditions, E. coli and P. aeruginosa showed very low susceptibility.In a later stage, suspensions of Gram-negative bacteria were processed with EDTA before photo-activation, obtaining a significant decrease in viable counts. In view of the results, if the combination of low porphyrin concentrations and short irradiation times will be effectivein vivo also, this approach could be a possible alternative to antibiotics, in particular against localized infections due to multidrug-resistant microorganisms.

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2017
• Tom: 66
• Numer: 4
• Opis fizyczny: p.533-536,ref.

Twórcy

autor

Bondi M.

• Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy

autor

Mazzini A.

• Private practice, Modena, Italy

autor

De Niederhausern S.

• Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy

autor

Iseppi R.

• Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy

autor

Messi P.

• Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy

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Identyfikatory

DOI

10.5604/01.3001.0010.7092