Uricemia in juvenile pigs model: effect of nephrectomy and potassium oxonate

• Autorzy: Mosiichuk N. , Grujic D. , Wolinsk J. , Podpryatov S.E. , Szczurek P. , Yatsenko T. , Shmihel H. , Drahanchuk O. , Pierzynowski S.G. , Goncharova Pierzynowska K.
• Języki publikacji: EN

Abstrakty

EN

Uric acid is the end product of dietary and endogenous purine metabolism in humans and higher primates. In all lower mammalian species it is converted to allantoin by liver uricase. The aim of this study was to investigate the uric acid turnover in pig model after nephrectomy surgery, fructose-enriched diet and potassium oxonate application. The first experiment was performed using 4 intact control pigs and 8 nephrectomized (5/6 nephrectomy) pigs. Both groups were fed high-fat diet enriched with 20% of fructose for 3 weeks. During the second experiment, as another approach to induce hyperuricemia, potassium oxonate solution (POx) was administered intravenously to 4 healthy pigs, once or twice per day. In the third preliminary experiment one healthy and two nephrectomized (9/10 nephrectomy) pigs were infused with POx to induce hyperuricemia. Results showed that 5/6 nephrecotomy did not affect plasma uric acid concentration for 25 days following surgery. The consumption of the highfat diet enriched with 20% of fructose did not result in the rise of plasma uric acid, either in healthy or nephrectomized pigs. Administration of POx solution to healthy and 9/10 nephrectomized pigs resulted in significantly increased plasma uric acid concentrations for 18 h and 24 h, respectively, following a single POx infusion. The present study expands today available data on uric acid metabolism in pigs as a model for exploring uricemia in human with kidney dysfunction

• Wydawca: -
• Czasopismo: Journal of Animal and Feed Sciences
• Rocznik: 2019
• Tom: 28
• Numer: 3
• Opis fizyczny: p.254-262,fig.,ref.

Twórcy

autor

Mosiichuk N.

• Vasyl Stefanyk Precarpathian National University, 76018, Ivano-Frankivs'k, Ukraine
• Department of Biology, Lund University, 223 62 Lund, Sweden

autor

Grujic D.

• Allena Pharmaceuticals, Newton, MA 02462, USA

autor

Wolinsk J.

• The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna, Poland

autor

Podpryatov S.E.

• Clinical Research Centre of Bonding/Welding Surgery and New Surgical Technologies at Kyiv Municipal Hospital Clinic No.1, 02091, Kyiv, Ukraine

autor

Szczurek P.

• Department of Animal Nutrition and Feed Sciences, National Research Institute of Animal Production, 32-083 Balice, Poland

autor

Yatsenko T.

• Department of Enzymes Chemistry and Biochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 01030, Kyiv, Ukraine

autor

Shmihel H.

• Vasyl Stefanyk Precarpathian National University, 76018, Ivano-Frankivs'k, Ukraine

autor

Drahanchuk O.

• The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna, Poland

autor

Pierzynowski S.G.

• Department of Biology, Lund University, 223 62 Lund, Sweden
• R and D Anara AB, 231 32 Trelleborg, Sweden

autor

Goncharova Pierzynowska K.

• Department of Biology, Lund University, 223 62 Lund, Sweden
• R and D Anara AB, 231 32 Trelleborg, Sweden

Bibliografia

• Bogdan V.F., Gupalo Yu. M., Gichka S.G., Furmanov Ju.O., LebedevO.V., NichitailoM.Ju., PetrenkoO.F., PodpryatovS.E., Podpriatov S.S., 2009. Development of high-frequency surgical electrofusion technology, performed with the use of automation systems. In: B.E. Paton, O.N. Ivanova (Editors). Tissue-preserving high-frequency electric welding surgery (in Russian). Naukova dumka. Kiev (Ukraine), pp. 68–99
• de Oliveira E.P., Burini R.C., 2012. High plasma uric acid concentration: causes and consequences. Diabetol. Metab. Syndr. 4, 12, https://doi.org/10.1186/1758-5996-4-12
• Fathallah-Shaykh S.A., Cramer M.T., 2014. Uric acid and the kidney. Pediatr. Nephrol. 29, 999–1008, https://doi.org/10.1007/s00467-013-2549-x
• Fridovich I., 1965. The competitive inhibition of uricase by oxonate and by related derivatives of s-triazines. J. Biol. Chem. 240, 2491–2494
• Gersch M.S., Mu W., Cirillo P., Reungjui S., Zhang L., Roncal C., Sautin Y.Y., Johnson R.J., Nakagawa T., 2007. Fructose, but not dextrose, accelerates the progression of chronic kidney disease. Am. J. Physiol. Renal. Physiol. 293, F1256–F1261, https://doi.org/10.1152/ajprenal.00181.2007
• Gupta A., Biyani M., Gupta M., Saltel M.E., 2011. Hypercreatinemia: think beyond acute kidney injury. Can. J. Urol. 18, 6066–6068
• Hatch M., Vaziri N.D., 1994. Enhanced enteric excretion of urate in rats with chronic renal failure. Clin. Sci. 86, 511–516, https://doi.org/10.1042/cs0860511
• Hatfield P.J., Simmonds H.A., Cameron J.S., Jones A.S., Cadenhead A., 1974. Effects of allopurinol and oxonic acid on pyrimidine metabolism in the pig. In: O. Sperling, A. De Vries, J.B. Wyngaarden (Editors). Purine Metabolism in Man. Plenum, New York (USA), pp. 637–638, https://doi.org/10.1007/978-1-4757-1433-3_33
• Heyman S.N., Rosenberger C., Rosen S., 2011. Acute kidney injury: lessons from experimental models. In: G.A. Herrera (Editor). Experimental Models for Renal Diseases. Pathogenesis and Diagnosis. Karger Publishers. Basel (Switzerland), pp. 286–296, https://doi.org/10.1159/000313957
• Hu Q.-H., Zhu J.-X., Ji J., Wei L.-L., Miao M.-X., Ji H., 2013. Fructus gardenia extract ameliorates oxonate-induced hyperuricemia with renal dysfunction in mice by regulating organic ion transporters and mOIT3. Molecules 18, 8976–8993, https://doi.org/10.3390/molecules18088976
• Ichida K., Matsuo H., Takada T. et al., 2012. Decreased extra-renal urate excretion is a common cause of hyperuricemia. Nat. Commun. 3, 764, https://doi.org/10.1038/ncomms1756
• Jalal D.I., Chonchol M., Chen W., Targher G., 2013. Uric acid as a target of therapy in CKD. Am. J. Kidney Dis. 61, 134–146, https://doi.org/10.1053/j.ajkd.2012.07.021
• Johnson R.J., Gaucher E.A., Sautin Y.Y., Henderson G.N., Angerhofer A.J., Benner S.A., 2008. The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease. Med. Hypotheses 71, 22–31, https://doi.org/10.1016/j.mehy.2008.01.017
• Johnson R.J., Nakagawa T., Jalal D., Sánchez-Lozada L.G., Kang D.- H., Ritz E., 2013a. Uric acid and chronic kidney disease: which is chasing which? Nephrol. Dial. Transplant. 28, 2221–2228, https://doi.org/10.1093/ndt/gft029
• Johnson R.J., Nakagawa T., Sanchez-Lozada L.G., Shafiu M., Sundaram S., Le M., Ishimoto T., Sautin Y.Y., Lanaspa M.A., 2013b. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes 62, 3307–3315, https://doi.org/10.2337/db12-1814
• Kang D.-H., Nakagawa T., 2005. Uric acid and chronic renal disease: possible implication of hyperuricemia on progression of renal disease. Semin. Nephrol. 25, 43–49, https://doi.org/10.1016/j.semnephrol.2004.10.001
• Kretowicz M., Johnson R.J., Ishimoto T., Nakagawa T., Manitius J., 2011. The impact of fructose on renal function and blood pressure. Int. J. Nephrol. 2011, 315879, https://doi.org/10.4061/2011/315879
• Lee S.J., Terkeltaub R.A., Kavanaugh A., 2006. Recent developments in diet and gout. Curr. Opin. Rheumatol. 18, 193–198, https://doi.org/10.1097/01.bor.0000209434.82096.1f
• Lee I.R., Yang L., Sebetso G., Allen R., Doan T.H.N., Blundell R., Lui E.Y.L., Morrow C.A., Fraser J.A., 2013. Characterization of the complete uric acid degradation pathway in the fungal pathogen Cryptococcus neoformans. PLoS ONE 8, e64292, https://doi.org/10.1371/journal.pone.0064292
• Levey A.S., Coresh J., 2012. Chronic kidney disease. Lancet 379, 165–180, https://doi.org/10.1016/S0140-6736(11)60178-5
• Malagrino P.A., Venturini G., Yogi P.S. et al., 2014. Catheter-based induction of renal ischemia/reperfusion in swine: description of an experimental model. Physiol. Rep. 2, e12150, https://doi.org/10.14814/phy2.12150
• Mandal A.K., Mount D.B., 2015. The molecular physiology of uric acid homeostasis. Annu. Rev. Physiol. 77, 323–345, https://doi.org/10.1146/annurev-physiol-021113-170343
• Murota I., Tamai T., Baba T., Sato N., Park E.Y., Nakamura Y., Sato K., 2012. Moderation of oxonate-induced hyperuricemia in rats via the ingestion of an ethanol-soluble fraction of a shark cartilage proteolytic digest. J. Funct. Foods 4, 459–464, https://doi.org/10.1016/j.jff.2012.02.004
• Podpryatov S.E., Shved O.E., Gupalo Yu.M., Podpriatov S.S., Lebedev A.V., Gichka S.G., Dubko A.G., Trunov A.E., Bernadsky V.V., Zelnichenko A.T., 2007. Artery crossing using automatic welding (in Ukrainian). Klin. Khir. 5, 55–57
• Rengman S., Fedkiv O., Botermans J., Svendsen J.R., Weström B., Pierzynowski S., 2009. An elemental diet fed, enteral or parenteral, does not support growth in young pigs with exocrine pancreatic insufficiency. Clin. Nutr. 28, 325–330, https://doi.org/10.1016/j.clnu.2009.02.010
• Roch-Ramel F., Peters G., 1978. Urinary excretion of uric acid in nonhuman mammalian species. In: W.N. Kelley, I.M. Weiner (Editors). Uric Acid. Handbook of Experimental Pharmacology (Continuation of Handbuch der experimentellen Pharmakologie), vol 51. Springer, Berlin (Germany), pp. 211–255, https://doi.org/10.1007/978-3-642-66867-8_9
• Simmonds H.A., Hatfield P.J., Cameron J.S., CadenheadA., 1976. Uric acid excretion by the pig kidney. Am. J. Physiol. 230, 1654–1661, https://doi.org/10.1152/ajplegacy.1976.230.6.1654
• Stavric B., Johnson W.J., Clayman S., Gadd R.E.A., Chartrand A., 1976. Effect of fructose administration on serum urate levels in the uricase inhibited rat. Experientia 32, 373–374, https://doi.org/10.1007/BF01940847
• Stavric B., Johnson W.J., Grice H.C., 1969. Uric acid nephropathy: an experimental model. Proc. Soc. Exp. Biol. Med. 130, 512–516, https://doi.org/10.3181/00379727-130-33593
• Stavric B., Nera E.A., 1978. Use of the uricase-inhibited rat as an animal model in toxicology. Clin. Toxicol. 13, 47–74, https://doi.org/10.3109/15563657808988228
• Swindle M.M., Makin A., Herron A.J., Clubb F.J., Frazier K.S., 2012. Swine as models in biomedical research and toxicology testing. Vet. Pathol. 49, 344–356, https://doi.org/10.1177/0300985811402846
• Szczurek P., Mosiichuk N., Woliński J., Yatsenko T., Grujic D., Lozinska L., Pieszka M., Święch E., Pierzynowski S.G., Goncharova K., 2017. Oral uricase eliminates blood uric acid in the hyperuricemic pig model. PLoS ONE 12, e0179195, https://doi.org/10.1371/journal.pone.0179195
• Terkeltaub R., 2010. Update on gout: new therapeutic strategies and options. Nat. Rev. Rheumatol. 6, 30–38, https://doi.org/10.1038/nrrheum.2009.236
• Vaziri N.D., 2006. Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences. Am. J. Physiol. Renal. Physiol. 290, F262–F272, https://doi.org/10.1152/ajprenal.00099.2005
• Yonetani Y., Ishii M., Iwaki K., 1980. Hyperuricemia induced by some antihypertensives and uricosuric drugs in oxonate-treated rats. Jpn. J. Pharmacol. 30, 829–840, https://doi.org/10.1254/jjp.30.829

Identyfikatory

DOI

10.22358/jafs/110436/2019