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2007 | 29 | 2 |
Tytuł artykułu

The influence of apigenin on membrane and action potential in the liverwort Conocephalum conicum

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Apigenin (4',5,7-trixydroxyflavone) is a member of the family of plant flavonoids considered to prevent a number of human diseases, for instance cancer development. It displays a lot of activities and part of its beneficial effects could come from its affinity to the cellular membranes. In the present study we used the liverwort Conocephalum conicum, a model plant in electrophysiological study. Intracellular microelectrode measurements were carried out to examine the effects of apigenin alone and in combination with verapamil on the resting and action potentials. The application of apigenin caused an increase of action potential amplitudes. An increase even by 110–131% with respect to the control was observed. Little increase was also found in the membrane potentials in apigenin treated plants. Verapamil, the known calcium channel inhibitor, caused gradual decline of AP amplitudes. When apigenin was used simultaneously with verapamil, still high APs were observed. Duration of action potentials amplitudes measuerd at a half of the amplitude decreased in either apigenin or apigenin and verapamil treated plants to 56–62% of the control. It is concluded that apigenin strongly affects the membranes and prevents inhibitory effect of verapamil probably interacting with calcium channel protein.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
29
Numer
2
Opis fizyczny
p.143-149,fig.,ref.
Twórcy
  • Department of Comparative Anatomy and Anthropology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland
autor
  • Department of Biophysics, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland
autor
  • Department of Biophysics, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland
autor
  • Department of Comparative Anatomy and Anthropology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland
Bibliografia
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
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