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2013 | 57 | 1 |

Tytuł artykułu

Use of calcium sulfate as a biomaterial in the treatment of bone fractures in rabbits – preliminary studies

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The paper presents preliminary results of the implantation of calcium sulfate type Hartform HF1 developed at the Institute of Glass and Ceramics in Warsaw. The study was conducted on 10 New Zealand White rabbits, in which after tibial osteotomy the biomateriał was implanted directly into the fracture site. The animals were divided into two groups based on the method of fracture stabilisation: intramedullary pinning using Kirschner wires in one group and acrylic external fixator in the other. After 12 weeks, bone union was observed in all animals as estimated by clinical and radiological findings. Histological tests revealed resorption of the biomateriał into the bone fracture area. It was concluded that type Hartform 1 calcium sulfate can be used as a biomateriał in veterinary orthopedics. Due to the lack of observable side effects during implantation and resorption, the material can be considered as a valuable ingredient in composite biomaterials containing calcium sulfate.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

57

Numer

1

Opis fizyczny

p.119-122,fig.,ref.

Twórcy

autor
  • Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences, 20-950 Lublin, Poland
autor
  • Department of Animal Physiology and Biostructure, Faculty of Veterinary Medicine, University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
  • Department of Bioceramic, Institute of Glass and Ceramic, 02-676 Warsaw, Poland

Bibliografia

  • 1. Allison D.C., Lindberg A.W., Sarnimi B., Mirzayan R., Menendez L.R.: A comparison of mineral bone graft substitutes for bone defects. US Oncol Hematol 2011, 7, 38-49.
  • 2. Brydone A.S., Meek D., Maclaine S.: Bone grafting, orthopaedic biomaterials, and the clinical need for bone engineering. J Eng Med 2010, 224, 1329-1343.
  • 3. Buhite R., Bobek L.: Calcium sulfate and platelet-rich plasma make a novel osteoinductive biomateriał for bone regeneration. J Translat Med 2007, 5, 13.
  • 4. Chen Z., Liu H., Liu X., Cui F-Z.: Injectable calcium sulfate/mineralized collagen-based bone repair materials with regulable self-setting properties. J Biomed Meter Res Part A 2011, 99A, 554-563.
  • 5. Lee G.H., Khoury J.G., Bell J-E., Buckwalter J.A.: Adverse reactions to OsteoSet bone graft substitute. The incidence in a consecutive series. Iowa Orthop J 2002, 22, 35-38.
  • 6. Nystrom L., Raw R., Buckwalter J., Morcuende J.A.: Acute intraoperative reactions during the injection of calcium sulfate bone cement for the treatment of unicameral bone cysts: a review of four cases. Iowa Orthop J 2008, 28,81-84.
  • 7. Pecora A., Petrone G., Iezzi G., Piattelli A.: Bone-defect healing with calcium-sulfate particles and cement: an experimental study in rabbit. J Biomed Mater Res Part B Appl Biomater 2004, 68B, 199-208.
  • 8. Parker A.C., Smith J.K., Courtney H.S., Haggard W.O.: Evaluation of two sources of calcium sulfate for a local drug delivery system: a pilot study. Clin Orthop Relat Res 2011, 469, 3008-3015.
  • 9. Peters C.L., Hines J.L., Bachus K.N., Craig M.A., Bloebaum R.D.: Biological effects of calcium sulfate as a bone graft in ovine metaphyseal defects. Wiley InterSci 2005, 10.1002, 456-462.
  • 10. Petruskevicius J., Nielsen S., Kaalund S., Knudsen P., Overgaard S.: No effect of Osteoset a bone graft substitute on bone healing in humans. Acta Orthop Scand 2002, 73, 575-578.
  • 11. Robinson D., Alk D., Sandbank J., Farber R., Halperin N.: Inflammatory reactions associated with a calcium sulfate bone substitute. Ann Transplant 1999, 3-4, 91-97
  • 12. Strocchi R., Orsini G., Iezzi G., Scarano A., Rubini A., Pecora G., Piattelli A.: Bone regeneration with calcium sulfate: evidence for increased angiogenesis in rabbits. J Oral Implantol 2002, 28, 273-278.
  • 13. Stubbs D., Deakin M., Chapman-Sheath P., Bruce W., Debes J., Gillies R.M., Walsh W.R.: In vivo evaluation of resorbable bone graft substitutes in a rabbit tibial defect model. Biomaterials 2004, 25, 5037-5044.
  • 14. Tang M., Shen X., Huang H.: Influence of α-calcium sulfate hemihydrate particle characteristic on the performance of calcium sulfate-based medical materials. Mat Sci Eng 2010, 30, 1107-1111.
  • 15. Thomas M.V., Puelo D.A.: Calcium sulfate: properties and clinical applications. J Biomed Mat Res Part B Appl Biomat 2008, 88B, 597-610.
  • 16. Turner T., Urban R., Gitelis S., Kuon K.N., Gunnar B.J.: Radiographic and histologic assessment of calcium sulfate in experimental animal models and clinical use as a resorbable bone-graft substitute, a bone-graft expander, and a method for local antibiotic delivery: one institution's experience. J Bone Joint Surg 2001, 83, 8- 18.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-7d27a141-551f-48de-8bee-a3ecf367d91f
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