Influence of importin α/β and exportin 1 on equine herpesvirus type 1 (EHV-1) replication in primary murine neurons

• Autorzy: Slonska A. , Cymerys J. , Skwarska J. , Golke A. , Banbura M. W.
• Języki publikacji: EN

Abstrakty

EN

Viruses replicating in the nucleus need to cross the nuclear membrane barrier during infection, therefore disruption of specific nuclear transport pathways is crucial for their replication cycle. In the present study we have investigated the influence of nucleo-cytoplasmic transport inhibitors – ivermectin and leptomycin B, on EHV-1 replication in primary murine neurons. Obtained results suggest that the examined proteins – exportin 1 and importin α/β may participate, but are not required, during EHV-1 infection. Based on these results, it can be assumed that EHV-1 is able to use other receptors for nucleo-cytoplasmic transport.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2013
• Tom: 16
• Numer: 4
• Opis fizyczny: p.749-751,fig.,ref.

Twórcy

autor

Slonska A.

• Division of Microbiology, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences – SGGW , Ciszewskiego 8, 02-786 Warsaw, Poland

autor

Cymerys J.

• Division of Microbiology, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences – SGGW , Ciszewskiego 8, 02-786 Warsaw, Poland

autor

Skwarska J.

• Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw University of Life Sciences – SGGW, Nowoursynowska 159, 02-776, Warsaw, Poland

autor

Golke A.

• Division of Microbiology, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences – SGGW , Ciszewskiego 8, 02-786 Warsaw, Poland

autor

Banbura M. W.

• Division of Microbiology, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences – SGGW , Ciszewskiego 8, 02-786 Warsaw, Poland

Bibliografia

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