Levels of oxidative stress markers: correlation with hepatic function and worm burden patients with schistosomiasis

• Autorzy: Cunha G.M.M. , Silva V. M. A. , Bessa K. D. G. , Bitencourt M. A. O. , Macedo U. B. O. , Freire-Neto F. P. , Martins R. R. , Assis C. F. , Lemos T. M. A. M. , Almeida M. G. , Freire A. C. G.
• Języki publikacji: EN

Abstrakty

EN

Schistosomiasis is caused by Schistosoma mansoni and is a public health problem in Brazil. The typical granulomatous lesion is associated with the increase in the oxidative damage by generation of free radicals. The aim of this work was to correlate some oxidative stress markers with the worm burden on carriers of schistosomiasis (n = 30) in the acute phase in comparison to healthy subjects (n = 30). The pro-oxidant parameter used was the colorimetric quantification of reactive substances to thiobarbituric acid, while the antioxidant markers used were blood content of reduced glutathione and determination of the activity of catalase. The worm burden was assessed by Kato-Katz method. The results pointed out that initially there was no difference in the catalase activity. However, there was a positive correlation between the increase in parasitic load and intensity of lipid peroxidation, and decrease in the content of reduced glutathione. Additionally, only the aspartate aminotransferase levels presented to be high, while there was a decrease in bilirubin level. Therefore, a possible association between the establishment of the oxidative stress in tissue and the parasitic load of Schistosoma mansoni is suggested.

Słowa kluczowe

EN

oxidative stress; worm burden; patient; hepatic function; schistosomiasis; Schistosoma mansoni; granulomatous lesion; inflammatory process; cellular immune response; liver; gut; glutathione; catalase

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 2012
• Tom: 57
• Numer: 2
• Opis fizyczny: p.160-166,fig.,ref.

Twórcy

autor

Cunha G.M.M.

• Faculdade de Farmacia, Departamento de Analises Clinicas e Toxicologicas, Universidade Federal do Rio Grande do Norte, Rua Gal. Gustavo Cordeiro de Farias, s/n, 2 Andar, Petropolis, CEP: 59012-570 Natal, Rio Grande do Norte, Brazil

autor

Silva V. M. A.

autor

Bessa K. D. G.

autor

Bitencourt M. A. O.

autor

Macedo U. B. O.

autor

Freire-Neto F. P.

autor

Martins R. R.

autor

Assis C. F.

autor

Lemos T. M. A. M.

autor

Almeida M. G.

autor

Freire A. C. G.

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