Clinical study on the application of tacrolimus and DMSO in the treatment of chronic superficial keratitis in dogs

• Autorzy: Balicki I.
• Języki publikacji: EN

Abstrakty

EN

The objective of this study was to assess the treatment of chronic superficial keratitis (CSK) in dogs with the use of tacrolimus and DMSO. The study was conducted on 16 dogs - 7 males and 9 females, aged 3 to 11 years, diagnosed with CSK. The disease was treated with ophthalmic drops containing 0.02% tacrolimus and 50% DMSO, administered to the ocular surface three times a day. Prior to the treatment and after 5 weeks of therapy, the corneal neovascularisation, pigmentation, and also the redness and depigmentation of the third eyelid margin were assessed. The percentage of the corneal surface afflicted with inflammatory processes was calculated on the basis of photographs taken with the use of IsoCalc.com’s Get Area software for Corel DRAW 12. It was found that the application of tacrolimus and DMSO caused a reduction of inflammatory process and neovascularisation in the cornea. The mean corneal surface afflicted with inflammatory processes was statistically significantly reduced from 69.9% to 43.9% (p ≤ 0.01) - in case of the right corneas, and from 58.9% to 38.6% in case of the left corneas. Of 32 corneas diagnosed with the pigmentation, the reduction of the pigmentation was observed in 14, while in 16 the pigmentation increased. The treatment of CSK with the use of tacrolimus and DMSO causes the reduction in terms of inflammatory processes and neovascularisation, but in many cases does not inhibit the progress of the pigmentation.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2012
• Tom: 15
• Numer: 4
• Opis fizyczny: p.667-676,fig.,ref.

Twórcy

autor

Balicki I.

• Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Głęboka 30, 20-612 Lublin, Poland

Bibliografia

• Attas-Fox L, Barkana Y, Iskhakov V, Rayvich S, Gerber Y, Morad Y, Avni I, Zadok D (2008) Topical tacrolimus 0.03% ointment for intractable allergic conjunctivitis: an open-label pilot study. Curr Eye Res 33: 545-549.
• Balicki I (2005) Research on diagnostic and treatment of chronic superficial keratitis in dogs. Postdoctoral dissertation, WAR Lublin 204: 16-34.
• Balicki I (2006) Research on DMSO and dexamethasone application for chronic superficial keratitis treatment in dogs. Scientific messenger of Lviv National Academy of Veterinary Medicine 8: 192-195.
• Balicki I (2008) Current methods of diagnosis and therapy of chronic superficial keratitis in dogs. Med Weter 64: 40-44.
• Balicki I, Trbolova A (2010) Clinical evaluation of tacrolimus eye drops for chronic superficial keratitis treatment in dogs. Bull Vet Inst Pulawy 54: 251-258.
• Balicki I, Ziółkowska G, Śmiech A (2008) Poliethiological ulcerative mycotic keratitis in a horse. Med Weter 64: 1407-1410.
• Ball MA, Rebhun WC, Trepanier L, Gaarder J, Schwark WS (1997) Corneal concentration and preliminary toxicological evaluation of an itraconazole/dimethyl sulphoxide ophtalmic ointment. J Vet Pharmacol Ther 20: 100-104.
• Bedford PG, Longstaffe JA (1979) Corneal pannus (chronic superficial keratitis) in the German shaphed dog. J Small Anim Pract 20: 41-56.
• Berdoulay A, English RV, Nadelstein B (2005) Effect of topical 0.02% tacrolimus aqueous suspension on tear production in dogs with keratoconjunctivitis sicca. Vet Ophthalmol 8: 225-232.
• Bigelbach A (1994) Topical use of cyclosporine in the treatment of corticosteroid resistant cases of chronic superfitial keratitis (Uberreiter) and plasma cell infiltration of the nictitating membrane. Europ J Comp Anim Pract 4: 31-38.
• Binnick SA, Shore SS, Corman A, Fleischmajer R (1977) Failure of dimethyl sulfoxide in the treatment of scleroderma. Arch Dermatol 113: 1398-1402.
• Brayton CF (1986) Dimethyl sulfoxide (DMSO): a review. Cornell Vet 76: 61-90.
• Chavkin MJ, Roberts MS, Salman MD, Severin GA, Scholten NJ (1994) Risk factors for development of chronic superficial keratitis in dogs. J Am Vet Med Assoc 204: 1630-1634.
• Clerc B (1996) Traitment des maladies g mediation immune et des maladies auto-immunes oculares du chien et du chat par la pommade a´ la cyclosporine. Prat Med Chir 31:73-81.
• Del Maestro R, Thaw HH, Bjo¨rk J, Planker M, Arfors KE. (1980) Free radicals as mediators of tissue injury. Acta Physiol Scand Suppl 492: 43-57.
• Gliger BC, Bentley E, Ollivier FJ (2007) Diseases and surgery of the canine cornea and sclera. In: Gelatt KN (ed) Veterinary Ophthalmology. 4th ed., Blackwell Publishing, Ames, pp 722-723.
• Gordon DM (1967) Dimethyl sulfoxide in ophtalmology, with especial reference to possible toxic effects. Ann NY Acad Sci 141: 392-401.
• Jokinen P, Rusanen EM, Kennedy LJ, Lohi H (2011) MHC class II risk haplotype associated with canine chronic superficial keratitis in German Shepherd dogs. Vet Immunol Immunopathol 140: 37-41.
• Joseph MA, Kaufman HE, Insler M (2005) Topical tacrolimus ointment for treatment of refractory anterior segment inflammatory disorders. Cornea 24: 417-420.
• Kawa P (1997) Badania nad wpływem środków hamujących aktywność i powstawanie wolnych rodników tlenowych na gojenie się doświadczalnego owrzodzenia rogówki. Doctoral Thesis, AM Lublin, Poland
• Kino T, Hatanaka H, Hashimoto M, Nishiyama M, Goto T, Okuhara M, Kohsaka M, Aoki H, Imanaka H (1987) FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. J Antibiot 40: 1249-1255.
• Kymionis GD, Goldman D, Ide T, Yoo SH (2008) Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. Cornea 27: 228-229.
• Maggs DJ (2008) Ocular pharmacology and therapeutics. In: Maggs DJ, Miller PE, Ofri R (ed) Slatter’s Fundamentals of Veterinary Ophthalmology. 4th ed., Saunders Elsevier, St. Louis, pp 50.
• Nell B, Walde I, Billich A, Vit P, Meingassner JG (2005) The effect of topical pimecrolimus on keratoconjunctivitis sicca and chronic superficial keratitis in dogs: results from an exploratory study. Vet Ophthalmol 8: 39-46.
• Nghiem P Pearson G, Langley RG (2001) Tacrolimus and pimecrolimus: from clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis. J Am Acad Dermatol 46: 228-241.
• Noel PR, Barnett KC, Davis RE, Jolly DW, Leahy JS, Mawdesley-Thomas LE, Shillam KW, Squires PF, Street AE, Tucker WC, Worden AN (1975) The toxicity of dimethyl sulphoxide (DMSO) for the dog, pig, rat and rabbit. Toxicology 3: 143-169.
• Rossa V, Kluxen G (1988) Significance of experimental cataracts for the development of senile cataracts exemplified by naphthalene and dimethyl sulfoxide-induced lens opacities. Fortschr Ophthalmol 85: 396-399.
• Rubin LF, Barnett KC (1967) Ocular effects of oral and dermal application of dimethyl sulfoxide in animals. Ann N Y Acad Sci 141: 333-345.
• Sakuma S, Higashi Y, Sato N, Sasakawa T, Sengoku T, Ohkubo Y, Amaya T, Goto T (2001) Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids). Int Immunopharmacol 1: 1219-1226.
• Sanchez S, Studer M, Currin P, Barlett P, Bounous D (2001) Listeria keratitis in a horse. Vet Ophthalmol 4: 217-219.
• Skrypuch OW, Tokarewicz AC, Willis NR (1987) Effects of dimethyl sulfoxide on a model of corneal alkali injury. Can J Ophtalmol 22: 17-20.
• Smith ER, Mason MM, Epstein E (1967) The influence of dimethyl sulphoxide on the dog with emphasis on the ophtalmologic examination. Ann N Y Acad Sci 141: 386-391
• Stades FC, Wyman M, Boevé MH, Neumann W, Spiess B (2007) Ophtalmology foqr the Veterinary Practitioner.Die Schlütersche Verlagsgesellschaft mbH & Co. KG, Hannover, pp 135-136.
• Toczołowski J, Wolski T, Klamut-Sory K (1992) Effect of drugs inhibiting the formation of hydroxide radicals on healing of experimental corneal ulcer. Klinika Oczna 94: 83-85.
• Virtanen HM, Reitamo S, Kari M, Kari O (2006) Effect of 0.03% tacrolimus ointment on conjunctival cytology in patients with severe atopic blepharoconjunctivitis: a retrospective study. Acta Opthalmol Scand 84: 693-695.
• Williams DL, Hoey AJ, Smitherman P (1995) Comparison of topical cyclosporin and dexamethasone for the treatment of chronic superficial keratitis in dogs. Vet Rec 137: 635-639.
• Yoshizumi MO, Banihashemi AR (1988) Experimental intravitreal ketoconazole in DMSO. Retina 8: 210-215.
• Yoshizumi MO, Niizawa JM, Meyers-Elliott R (1986) Ocular toxicity of intravitreal vidarabine solubilized in dimethyl sulfoxide. Arch Ophthalmol 104: 426-430

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