Prp4 kinase is required for proper segregation of chromosomes during meiosis in Schizosaccharomyces pombe

• Autorzy: Pozgajova M. , Cipak L. , Trakovicka A.
• Języki publikacji: EN

Abstrakty

EN

 Chromosome segregation during meiosis is a complex process, which leads to production of four haploid gametes from two precursor cells. Reversible phosphorylation of proteins plays a crucial role in this process. The Schizosaccharomyces pombe Prp4 is an essential serine/threonine protein kinase, which belongs to the Clk/Sty family. To study the role of Prp4 in meiosis, we analysed chromosome segregation in a strain carrying conditional analog-sensitive allele of Prp4 protein kinase (prp4-as2). Our data show, that Prp4 protein kinase plays important role in chromosome segregation during meiosis, as revealed by enhanced missegregation of chromosomes in prp4-as2 mutant cells.

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2013
• Tom: 60
• Numer: 4
• Opis fizyczny: p.871-873,fig.,ref.

Twórcy

autor

Pozgajova M.

• Slovak University of Agriculture, Department of Genetics and Breeding Biology, Nitra, Slovakia

autor

Cipak L.

• Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia

autor

Trakovicka A.

• Slovak University of Agriculture, Department of Genetics and Breeding Biology, Nitra, Slovakia

Bibliografia

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