Curcumin ameliorates experimental autoimmune acute myocarditis in rats as evidenced by decrease in thioredoxin immunoreactivity

• Autorzy: Ahmed A.M. , El-Fouhil A.F. , Mohamed R.A. , Atteya M. , Abdel-Baky N.A. , AlRoalle A.H. , Aldahmash A.M.
• Języki publikacji: EN

Abstrakty

EN

This study was performed to investigate the effect of curcumin on cardiac myosin- -induced autoimmune myocarditis in rats and the change in thioredoxin (TRX) immunoreactivity in cardiomyocytes following curcumin treatment. Twenty-four six-week-old male Wistar rats were randomly allocated into 4 groups of 6 rats each. Group I received neither curcumin nor myosin. Group II received an oral solution of 1 g/kg/day of curcumin daily, from day 1 to day 21. To induce myocarditis, animals of both group III and group IV were injected by 1 mg of porcine cardiac myosin on days 1 and 8. In addition, animals of group IV received an oral solution of 1 g/kg/day of curcumin daily, from day 1 to day 21. Serum levels of creatine phosphokinase, troponin-T, tumour necrosis factor-alpha and interleukin-6 were estimated. Hearts were processed for histopathological and immunohistochemical studies. Serum biomarkers levels were significantly increased in myocarditis group as compared to other groups. The intake of curcumin significantly reduced the deviation in these markers. Sections of the wall of the heart from myocarditis group were characterised by inflammatory cell infiltration. Most of cardiomyocytes showed pyknotic nuclei and increased sarcoplasmic eosinophilia with strong immunoreactivity for TRX. Sections from myocarditis-curcumin group showed normal architecture with moderate immunoreactivity for TRX. The present study demonstrated that curcumin ameliorates acute myocarditis in rats and encouraged the estimation of serum level of TRX as a relevant indicator for the evaluation of the progress of acute myocarditis. (Folia Morphol 2015; 74, 3: 318–324)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2015
• Tom: 74
• Numer: 3
• Opis fizyczny: p.318-324,fig.,ref.

Twórcy

autor

Ahmed A.M.

• Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia

autor

El-Fouhil A.F.

• Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia

autor

Mohamed R.A.

• Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia
• Department of Histology, Faculty of Medicine, Cairo University, Cairo, Egypt

autor

Atteya M.

• Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia

autor

Abdel-Baky N.A.

• Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
• Department of Pharmacology, College of Pharmacy, Al-Azhar University, Cairo, Egypt

autor

AlRoalle A.H.

• Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia

autor

Aldahmash A.M.

• Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Identyfikatory

DOI

10.5603/FM.2015.0048