Effect of novel pentabromobenzylisothioureas on T98G human glioblastoma cell lines and SEGA-derived cultures

• Autorzy: Pucko E.B. , Koronkiewicz M. , Kazimierczuk Z. , Ostrowski R. P. , Matyja E.
• Języki publikacji: EN

Abstrakty

EN

Gliomas are the most common primary brain tumours characterized by infiltrative cell growth. The specific novelty inhibitors of constitutively active serine/threonine kinase (CK2), i.e. isothiourea derivatives induce apoptosis and affect proliferation in some human cancer cells. We examined the cytotoxic and proapoptotic effect of selected modified isothiourea derivatives – pentabromobenzylisothioureas (ZKKs) against T98G adult human glioblastoma cell lines and cultures derived from rare, low-grade pediatric brain tumour of a mixed glioneuronal lineage (subependymal giant cell astrocytoma – SEGA), and normal human cultured astrocytes. ZKK-3 and ZKK-2 appeared to be the most effective compounds that induce apoptosis and exhibit strong anti-proliferative effect on neoplastic astroglial cells determined by flow cytometry analysis and Multisizer3 Beckman Coulter. Treatment of T98G cell line and SEGAderived cell cultures with 50 µM ZKK-3 and ZKK-2 for 48 h resulted in apoptosis and inhibition of cell proliferation up to 60% and 50% respectively. These results might suggest the potential anti-tumour effect of selected ZKKs related with glioma-derived neoplasms.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.63-64

Twórcy

autor

Pucko E.B.

• Department of Experimental and Clinical Neuropathology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Koronkiewicz M.

• Department of Cell Biology, National Medicines Institute, Warsaw, Poland

autor

Kazimierczuk Z.

• Institute of Chemistry, Warsaw Life Sciences University, Warsaw, Poland

autor

Ostrowski R. P.

• Department of Experimental and Clinical Neuropathology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Matyja E.

• Department of Experimental and Clinical Neuropathology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland