Effects of acute administration of cannabidiol on food intake in deprived rats

• Autorzy: Ignatowska-Jankowska B. , Jankowski M. , Torczynska A. , Kurrek A. , Swiergiel A.
• Języki publikacji: EN

Abstrakty

EN

Cannabidiol (CBD) is a major non-psychotropic constituent of Cannabis. The endocannabinoid system, which can be modulated by administration of CBD, is known to play an important role in control of food intake and energy balance. In recent years, numerous studies have revealed various pharmacological effects of CBD such as neuroprotective, analgetic, anxiolytic, antipsychotic and anti-inflammatory properties, and also antitumor potential. Surprisingly, very few reports concern effects of CBD on feeding behavior. Our previous studies revealed decreased body weight gain following repeated CBD administration in rats. The present study aimed to assess acute food intake in deprived rats under standard (SD) and high fat diet (HFD). Adult male Wistar rats (n=40), weighing approximately 350 ± 30 g were food deprived for 24 h and 30 minutes before return of food rats received intraperitoneal injections of CBD (5 mg/kg) or the vehicle. Rats were fed with SD (12% kcal from fat) only, or had additional access to HFD (60% kcal from fat, 10% kcal from sucrose). Food and water intake was measured 1 h, 2 h, 3 h and 24 h after animals were allowed ad libitum access to their assigned diet. Administration of CBD induced significant decrease in food intake of deprived rats within first 3 hours after food was returned in rats fed with SD only. Total energy intake within 24 h was not significantly altered in rats fed with SD. No change in total energy intake or preference of SD and HFD was observed in rats that had access to free choice HFD. CBD did not affect water intake or defecation. The results indicate that acute dose of CBD may decrease food intake in food deprived animals fed with SD, but not in rats having access to HFD. The data indicate that effects of acute CBD administration in deprived rats depend on type of diet.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: S
• Opis fizyczny: p.59-60

Twórcy

autor

Ignatowska-Jankowska B.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Jankowski M.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Torczynska A.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Kurrek A.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Swiergiel A.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

Uwagi

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